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- W4310784472 abstract "Diverse DNA-deforming processes are impacted by the local mechanical and structural properties of DNA, which in turn depend on local sequence and epigenetic modifications. Deciphering this mechanical code (that is, this dependence) has been challenging due to the lack of high-throughput experimental methods. Here we present a comprehensive characterization of the mechanical code. Utilizing high-throughput measurements of DNA bendability via loop-seq, we quantitatively established how the occurrence and spatial distribution of dinucleotides, tetranucleotides and methylated CpG impact DNA bendability. We used our measurements to develop a physical model for the sequence and methylation dependence of DNA bendability. We validated the model by performing loop-seq on mouse genomic sequences around transcription start sites and CTCF-binding sites. We applied our model to test the predictions of all-atom molecular dynamics simulations and to demonstrate that sequence and epigenetic modifications can mechanically encode regulatory information in diverse contexts." @default.
- W4310784472 created "2022-12-17" @default.
- W4310784472 creator A5006399866 @default.
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- W4310784472 date "2022-12-01" @default.
- W4310784472 modified "2023-10-14" @default.
- W4310784472 title "Deciphering the mechanical code of the genome and epigenome" @default.
- W4310784472 cites W1494314295 @default.
- W4310784472 cites W1546374223 @default.
- W4310784472 cites W1559480198 @default.
- W4310784472 cites W1607200676 @default.
- W4310784472 cites W1963604994 @default.
- W4310784472 cites W1963658914 @default.
- W4310784472 cites W1965034379 @default.
- W4310784472 cites W1968122824 @default.
- W4310784472 cites W1971403296 @default.
- W4310784472 cites W1978564348 @default.
- W4310784472 cites W1978985606 @default.
- W4310784472 cites W1979204453 @default.
- W4310784472 cites W1988294855 @default.
- W4310784472 cites W1988997227 @default.
- W4310784472 cites W1990893875 @default.
- W4310784472 cites W1992005588 @default.
- W4310784472 cites W1995841566 @default.
- W4310784472 cites W1996104196 @default.
- W4310784472 cites W1996245875 @default.
- W4310784472 cites W1996813139 @default.
- W4310784472 cites W1996852546 @default.
- W4310784472 cites W1997077880 @default.
- W4310784472 cites W2002439270 @default.
- W4310784472 cites W2005912066 @default.
- W4310784472 cites W2007071268 @default.
- W4310784472 cites W2009780091 @default.
- W4310784472 cites W2011548771 @default.
- W4310784472 cites W2012627860 @default.
- W4310784472 cites W2012680246 @default.
- W4310784472 cites W2013803515 @default.
- W4310784472 cites W2016390846 @default.
- W4310784472 cites W2017668896 @default.
- W4310784472 cites W2017789182 @default.
- W4310784472 cites W2020824064 @default.
- W4310784472 cites W2024280474 @default.
- W4310784472 cites W2034815580 @default.
- W4310784472 cites W2035797443 @default.
- W4310784472 cites W2038874225 @default.
- W4310784472 cites W2041804048 @default.
- W4310784472 cites W2053742705 @default.
- W4310784472 cites W2056360984 @default.
- W4310784472 cites W2066997247 @default.
- W4310784472 cites W2067924339 @default.
- W4310784472 cites W2069545688 @default.
- W4310784472 cites W2071962674 @default.
- W4310784472 cites W2079797742 @default.
- W4310784472 cites W2084744901 @default.
- W4310784472 cites W2089441618 @default.
- W4310784472 cites W2090037139 @default.
- W4310784472 cites W2091538508 @default.
- W4310784472 cites W2092044900 @default.
- W4310784472 cites W2093777918 @default.
- W4310784472 cites W2094829545 @default.
- W4310784472 cites W2095402653 @default.
- W4310784472 cites W2095994064 @default.
- W4310784472 cites W2101536723 @default.
- W4310784472 cites W2123032740 @default.
- W4310784472 cites W2130306291 @default.
- W4310784472 cites W2135184237 @default.
- W4310784472 cites W2137390416 @default.
- W4310784472 cites W2155844132 @default.
- W4310784472 cites W2156071334 @default.
- W4310784472 cites W2157810963 @default.
- W4310784472 cites W2158177848 @default.
- W4310784472 cites W2159710424 @default.
- W4310784472 cites W2160471420 @default.
- W4310784472 cites W2162563461 @default.
- W4310784472 cites W2170516638 @default.
- W4310784472 cites W2273790193 @default.
- W4310784472 cites W2310029472 @default.
- W4310784472 cites W2323093230 @default.
- W4310784472 cites W2409146838 @default.
- W4310784472 cites W2532816831 @default.
- W4310784472 cites W2553449527 @default.
- W4310784472 cites W2769058621 @default.
- W4310784472 cites W2796205786 @default.
- W4310784472 cites W2797018392 @default.
- W4310784472 cites W2909764080 @default.
- W4310784472 cites W2911555896 @default.
- W4310784472 cites W2931945594 @default.
- W4310784472 cites W2953216070 @default.
- W4310784472 cites W2968658941 @default.
- W4310784472 cites W2980812100 @default.
- W4310784472 cites W2982555675 @default.
- W4310784472 cites W3001088794 @default.
- W4310784472 cites W30415900 @default.