Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310784703> ?p ?o ?g. }
- W4310784703 abstract "Abstract Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling, antigen-specific T cells are poised to respond to local insults, making their phenotype important in the relationship between host and microbes. Here we show that MHC-II restricted, commensal-reactive T cells in the colon of both humans and mice acquire transcriptional and functional characteristics associated with innate-like T cells. This cell population is abundant and conserved in the human and murine colon and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis. T cells with this phenotype are increased in ulcerative colitis patients, and their presence aggravates pathology in dextran sodium sulphate-treated mice, pointing towards a pathogenic role in colitis. Our findings add to the expanding spectrum of innate-like immune cells positioned at the frontline of intestinal immune surveillance, capable of acting as sentinels of microbes and the local cytokine milieu." @default.
- W4310784703 created "2022-12-17" @default.
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- W4310784703 date "2022-12-03" @default.
- W4310784703 modified "2023-10-18" @default.
- W4310784703 title "A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice" @default.
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- W4310784703 doi "https://doi.org/10.1038/s41467-022-35126-3" @default.
- W4310784703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36463279" @default.