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- W4310794763 abstract "Amaç: Bu derlemede beyinde yaşlanmayla birlikte oluşan moleküler değişimlerin anlatılması amaçlanmıştır. Beyin yaşlanmasının moleküler mekanizmaları; oksidatif stres, mitokondriyal disfonksiyon, endoplazmik retikulum stres, otofaji, inflamasyon, lizozom ve proteazom işlevinin bozulması, bozulmuş DNA onarımı başlıkları altında toplanmış ve bu konulara odaklanılmıştır.
 Sonuç ve Tartışma: Yaşlanma, muhtemelen organizmalardaki hasar birikiminden ve/veya bakım ve onarım mekanizmalarındaki düşüşten kaynaklanan çok faktörlü bir süreçtir. Yaşlanmayla birlikte beyinde de yapısal ve fonksiyonel birçok değişim meydana gelmektedir. Bu değişiklikler nörodejeneratif bozukluklarla birlikte Alzheimer, Parkinson gibi hastalıklara yatkınlık oluşturmaktadır. Beyin yaşlandığında öğrenme, karar verme, hafıza gibi yeteneklerinde azalmalar görülmektedir. Beyin yaşlanmasına bağlı hastalıklara ve fonksiyonel bozukluklara karşı terapötik veya koruyucu yaklaşımlar geliştirmek için beyin yaşlanmasının moleküler düzeydeki mekanizmalarının aydınlatılmasına ihtiyaç vardır." @default.
- W4310794763 created "2022-12-18" @default.
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- W4310794763 date "2022-11-21" @default.
- W4310794763 modified "2023-09-30" @default.
- W4310794763 title "BEYİN YAŞLANMASINDA MOLEKÜLER MEKANİZMALAR" @default.
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- W4310794763 doi "https://doi.org/10.33483/jfpau.1099963" @default.
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