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- W4310797921 abstract "(Molecular Therapy 20, 306–316; February 2012) In the originally published version of this article, mistakes were present in the Western blots of Figure 4d, including the identical PCNA bands for Ad11 hexon expression in Capan-2 and PC-3. The hexon bands for PC-3 were identical to those of Figure 6b when different blot results should have been presented. The error was due to the inclusion of incorrect scanned blots and their misarrangement in Figure 4d. The corrected Figure 4d is shown below. These corrections do not change the conclusions of the paper, and the authors apologize for this error.Figure 4d. Mechanisms involved in the attenuated oncolytic potency of adenovirus serotype 11 (Ad11) (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11Wong et al.Molecular TherapyFebruary, 2012In BriefOncolytic adenoviruses based on serotype 5 (Ad5) have several shortcomings, including the downregulation of its receptor in cancer cells, high prevalence of neutralizing antibodies and hepatotoxicity. Another adenoviral serotype, Ad11, could overcome these obstacles. Here, we show that human cancer cell lines express higher levels of the Ad11 receptor CD46, resulting in much better infectivity than Ad5. Surprisingly, only 36% (9/25) of the cell lines were more sensitive to Ad11- than to Ad5-mediated cytotoxicity. Full-Text PDF Open Archive" @default.
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- W4310797921 date "2023-01-01" @default.
- W4310797921 modified "2023-09-28" @default.
- W4310797921 title "Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11" @default.
- W4310797921 doi "https://doi.org/10.1016/j.ymthe.2022.11.016" @default.
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