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- W4310836111 abstract "Abstract Early embryonic development depends on proper utilization and clearance of maternal transcriptomes. How these processes are spatiotemporally regulated remains unclear. Here we show that nuclear RNA‐binding protein Rbm14 and maternal mRNAs co‐phase separate into cytoplasmic condensates to facilitate vertebrate blastula‐to‐gastrula development. In zebrafish, Rbm14 condensates were highly abundant in blastomeres and markedly reduced after prominent activation of zygotic transcription. They concentrated at spindle poles by associating with centrosomal γ‐tubulin puncta and displayed mainly asymmetric divisions with a global symmetry across embryonic midline in 8‐ and 16‐cell embryos. Their formation was dose‐dependently stimulated by m 6 A, but repressed by m 5 C modification of the maternal mRNA. Furthermore, deadenylase Parn co‐phase separated with these condensates, and this was required for deadenylation of the mRNAs in early blastomeres. Depletion of Rbm14 impaired embryonic cell differentiations and full activations of the zygotic genome in both zebrafish and mouse and resulted in developmental arrest at the blastula stage. Our results suggest that cytoplasmic Rbm14 condensate formation regulates early embryogenesis by facilitating deadenylation, protection, and mitotic allocation of m 6 A‐modified maternal mRNAs, and by releasing the poly(A)‐less transcripts upon regulated disassembly to allow their re‐polyadenylation and translation or clearance." @default.
- W4310836111 created "2022-12-19" @default.
- W4310836111 creator A5003363628 @default.
- W4310836111 creator A5004498551 @default.
- W4310836111 creator A5004973358 @default.
- W4310836111 creator A5019291511 @default.
- W4310836111 creator A5023166782 @default.
- W4310836111 creator A5039832739 @default.
- W4310836111 creator A5045913607 @default.
- W4310836111 creator A5091688695 @default.
- W4310836111 date "2022-12-07" @default.
- W4310836111 modified "2023-09-26" @default.
- W4310836111 title "Maternal <scp>mRNA</scp> deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development" @default.
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