Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310839710> ?p ?o ?g. }
- W4310839710 abstract "Despite the concerted efforts within the management of brain malignancies over the past few decades, primary brain cancers remain an obscure challenge with unfavourable outcomes for the patients. Glioblastomas (GBM) and medulloblastomas afford the most prevalent brain tumours and account for markedly high mortality rates within affected patients. The unmet clinical requirements for an early diagnostic biomarker and effective treatment have shed light onto microRNAs (miRNAs). These are small, endogenous noncoding RNAs involved in a wide spectrum of biological processes, such as post-translational modification, tumorigenesis, angiogenesis, invasiveness, and apoptosis. Increased expression of miR-21 has been shown to have devastating effects upon patients with brain tumours, and it could be used as a diagnostic biomarker and an early relapse indicator. miRNAs such as miR-128a, miR-34a, miR-7 and miR-1253 have demonstrated tumour suppressive properties and could serve as putative therapeutic agents. MiRNA signatures, such as miR-21 and miR-10b could be incorporated as potential prognostic indicators for advanced and metastatic brain malignancies, whereas miR-221/222 cluster has a therapeutic potential to sensitise cancerous cells towards radiotherapy. Herein, we summarised current knowledge on how miRNAs with significant role in glioblastomas and medulloblastomas specifically can be effectively used as promising brain cancer diagnostics, prognostics, and therapeutics." @default.
- W4310839710 created "2022-12-19" @default.
- W4310839710 creator A5017619219 @default.
- W4310839710 creator A5023214943 @default.
- W4310839710 creator A5038057218 @default.
- W4310839710 creator A5059731124 @default.
- W4310839710 date "2022-11-27" @default.
- W4310839710 modified "2023-09-26" @default.
- W4310839710 title "MicroRNA Biomarkers in Primary Brain Malignancies" @default.
- W4310839710 cites W1495644609 @default.
- W4310839710 cites W1894780382 @default.
- W4310839710 cites W1913795889 @default.
- W4310839710 cites W1919421958 @default.
- W4310839710 cites W1943108244 @default.
- W4310839710 cites W1968525732 @default.
- W4310839710 cites W1969656021 @default.
- W4310839710 cites W1972430277 @default.
- W4310839710 cites W1974234783 @default.
- W4310839710 cites W1976048929 @default.
- W4310839710 cites W1978396691 @default.
- W4310839710 cites W1988793069 @default.
- W4310839710 cites W2027097496 @default.
- W4310839710 cites W2033541023 @default.
- W4310839710 cites W2041328373 @default.
- W4310839710 cites W2047308202 @default.
- W4310839710 cites W2049479334 @default.
- W4310839710 cites W2049836150 @default.
- W4310839710 cites W2066527875 @default.
- W4310839710 cites W2085910493 @default.
- W4310839710 cites W2087891885 @default.
- W4310839710 cites W2093364931 @default.
- W4310839710 cites W2097372335 @default.
- W4310839710 cites W2099099087 @default.
- W4310839710 cites W2099517697 @default.
- W4310839710 cites W2116641097 @default.
- W4310839710 cites W2119015197 @default.
- W4310839710 cites W2123129285 @default.
- W4310839710 cites W2130979840 @default.
- W4310839710 cites W2131250676 @default.
- W4310839710 cites W2134895500 @default.
- W4310839710 cites W2136991248 @default.
- W4310839710 cites W2148430070 @default.
- W4310839710 cites W2151911276 @default.
- W4310839710 cites W2154951934 @default.
- W4310839710 cites W2155412493 @default.
- W4310839710 cites W2167707579 @default.
- W4310839710 cites W2169314869 @default.
- W4310839710 cites W2170736348 @default.
- W4310839710 cites W2260849462 @default.
- W4310839710 cites W2317449198 @default.
- W4310839710 cites W2345878551 @default.
- W4310839710 cites W2410481617 @default.
- W4310839710 cites W2474895768 @default.
- W4310839710 cites W2499631704 @default.
- W4310839710 cites W2610766532 @default.
- W4310839710 cites W2743981317 @default.
- W4310839710 cites W2765199261 @default.
- W4310839710 cites W2767426525 @default.
- W4310839710 cites W2786479496 @default.
- W4310839710 cites W2792464686 @default.
- W4310839710 cites W2793963805 @default.
- W4310839710 cites W2795607856 @default.
- W4310839710 cites W2811212358 @default.
- W4310839710 cites W2884741638 @default.
- W4310839710 cites W2888668805 @default.
- W4310839710 cites W2898784280 @default.
- W4310839710 cites W2899532397 @default.
- W4310839710 cites W2901131915 @default.
- W4310839710 cites W2903357088 @default.
- W4310839710 cites W2922515674 @default.
- W4310839710 cites W2930687275 @default.
- W4310839710 cites W2942569017 @default.
- W4310839710 cites W2946714259 @default.
- W4310839710 cites W2947403474 @default.
- W4310839710 cites W2947478096 @default.
- W4310839710 cites W2966931392 @default.
- W4310839710 cites W2982780080 @default.
- W4310839710 cites W2985756101 @default.
- W4310839710 cites W2989832464 @default.
- W4310839710 cites W2993255485 @default.
- W4310839710 cites W3009050027 @default.
- W4310839710 cites W3025279674 @default.
- W4310839710 cites W3039704746 @default.
- W4310839710 cites W3044256881 @default.
- W4310839710 cites W3083695292 @default.
- W4310839710 cites W3088606085 @default.
- W4310839710 cites W3097037601 @default.
- W4310839710 cites W3118988966 @default.
- W4310839710 cites W3131954798 @default.
- W4310839710 cites W3157590672 @default.
- W4310839710 cites W3164974908 @default.
- W4310839710 cites W3171771536 @default.
- W4310839710 cites W3172025073 @default.
- W4310839710 cites W3183246687 @default.
- W4310839710 cites W3185600151 @default.
- W4310839710 cites W3187298821 @default.
- W4310839710 cites W3196997318 @default.
- W4310839710 cites W4200188411 @default.
- W4310839710 cites W4214583296 @default.
- W4310839710 cites W4214812612 @default.