Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310856908> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4310856908 endingPage "e251966" @default.
- W4310856908 startingPage "e251966" @default.
- W4310856908 abstract "Pembrolizumab, a humanised monoclonal antibody and immune checkpoint inhibitor (ICI) that blocks programmed death receptor 1 and its ligands, is an effective immunotherapy for malignancies such as melanoma , lung, head and neck, cancers, and Hodgkin’s lymphoma. It has an overall response rate between 73% and 83%, with complete response rate of 27%–30%. It is well tolerated with minor side effects in 70% of cases characterised by fatigue, rash, pruritus and diarrhoea. In rare cases, more serious and life-threatening complications can occur at a rate of 0.3%–1.3%. We report a case of a woman in her 70s with non-small-cell lung cancer treated with ICI. She presented to the emergency department with left-sided ptosis and muscle weakness 3 weeks of her first dose of pembrolizumab infusion as a treatment plan of her cancer. She was diagnosed with myasthenia gravis, myocarditis and myositis as ICI-induced immune-related adverse effects resistant to medical intervention. We wish to raise awareness of the triad of life-threatening complication of ICI therapy that accounts for 30%–50% of fatal complications." @default.
- W4310856908 created "2022-12-19" @default.
- W4310856908 creator A5013975131 @default.
- W4310856908 creator A5054441189 @default.
- W4310856908 creator A5064418096 @default.
- W4310856908 creator A5086057200 @default.
- W4310856908 date "2022-12-01" @default.
- W4310856908 modified "2023-09-29" @default.
- W4310856908 title "Myasthenia gravis, myositis and myocarditis: a fatal triad of immune-related adverse effect of immune checkpoint inhibitor treatment" @default.
- W4310856908 cites W2789315292 @default.
- W4310856908 cites W2803500132 @default.
- W4310856908 cites W2804734521 @default.
- W4310856908 cites W2891486030 @default.
- W4310856908 cites W2901128794 @default.
- W4310856908 cites W2943406880 @default.
- W4310856908 cites W2945043419 @default.
- W4310856908 cites W2947945944 @default.
- W4310856908 cites W2959700837 @default.
- W4310856908 cites W2982545924 @default.
- W4310856908 cites W3000961096 @default.
- W4310856908 cites W3010263808 @default.
- W4310856908 cites W3043779304 @default.
- W4310856908 cites W3133972944 @default.
- W4310856908 cites W4226360696 @default.
- W4310856908 cites W4232349440 @default.
- W4310856908 doi "https://doi.org/10.1136/bcr-2022-251966" @default.
- W4310856908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36593626" @default.
- W4310856908 hasPublicationYear "2022" @default.
- W4310856908 type Work @default.
- W4310856908 citedByCount "3" @default.
- W4310856908 countsByYear W43108569082023 @default.
- W4310856908 crossrefType "journal-article" @default.
- W4310856908 hasAuthorship W4310856908A5013975131 @default.
- W4310856908 hasAuthorship W4310856908A5054441189 @default.
- W4310856908 hasAuthorship W4310856908A5064418096 @default.
- W4310856908 hasAuthorship W4310856908A5086057200 @default.
- W4310856908 hasConcept C121608353 @default.
- W4310856908 hasConcept C126322002 @default.
- W4310856908 hasConcept C141071460 @default.
- W4310856908 hasConcept C197934379 @default.
- W4310856908 hasConcept C2777701055 @default.
- W4310856908 hasConcept C2778105408 @default.
- W4310856908 hasConcept C2778570526 @default.
- W4310856908 hasConcept C2780030458 @default.
- W4310856908 hasConcept C2780057760 @default.
- W4310856908 hasConcept C2780875844 @default.
- W4310856908 hasConcept C2781232998 @default.
- W4310856908 hasConcept C71924100 @default.
- W4310856908 hasConceptScore W4310856908C121608353 @default.
- W4310856908 hasConceptScore W4310856908C126322002 @default.
- W4310856908 hasConceptScore W4310856908C141071460 @default.
- W4310856908 hasConceptScore W4310856908C197934379 @default.
- W4310856908 hasConceptScore W4310856908C2777701055 @default.
- W4310856908 hasConceptScore W4310856908C2778105408 @default.
- W4310856908 hasConceptScore W4310856908C2778570526 @default.
- W4310856908 hasConceptScore W4310856908C2780030458 @default.
- W4310856908 hasConceptScore W4310856908C2780057760 @default.
- W4310856908 hasConceptScore W4310856908C2780875844 @default.
- W4310856908 hasConceptScore W4310856908C2781232998 @default.
- W4310856908 hasConceptScore W4310856908C71924100 @default.
- W4310856908 hasIssue "12" @default.
- W4310856908 hasLocation W43108569081 @default.
- W4310856908 hasLocation W43108569082 @default.
- W4310856908 hasOpenAccess W4310856908 @default.
- W4310856908 hasPrimaryLocation W43108569081 @default.
- W4310856908 hasRelatedWork W2791158187 @default.
- W4310856908 hasRelatedWork W2885240644 @default.
- W4310856908 hasRelatedWork W2899240190 @default.
- W4310856908 hasRelatedWork W2981928411 @default.
- W4310856908 hasRelatedWork W2993996889 @default.
- W4310856908 hasRelatedWork W3004757060 @default.
- W4310856908 hasRelatedWork W3016822790 @default.
- W4310856908 hasRelatedWork W3026597669 @default.
- W4310856908 hasRelatedWork W4313002270 @default.
- W4310856908 hasRelatedWork W4313404390 @default.
- W4310856908 hasVolume "15" @default.
- W4310856908 isParatext "false" @default.
- W4310856908 isRetracted "false" @default.
- W4310856908 workType "article" @default.