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- W4310859954 abstract "An acute exacerbation of interstitial lung disease (ILD) is an acute deterioration that can occur at any time and is associated with significant morbidity and mortality rates. We herein report three patients with ILD who experienced acute respiratory failure after SARS-CoV-2 messenger RNA vaccination. All the patients were male; the mean age was 77 years. They had a smoking history that ranged from 10 to 30 pack-years. Duration from the vaccination to the onset of respiratory failure was 1 day in two patients and 9 days in one patient. In an autopsied case, lung pathologic evidence indicated diffuse alveolar damage superimposed on usual interstitial pneumonia. In the other two cases, CT scans showed diffuse ground-glass opacities and subpleural reticulation, which suggests acute exacerbation of ILD. Two patients were treated successfully with high-dose methylprednisolone. Although benefits of vaccination outweigh the risks associated with uncommon adverse events, patients with chronic lung diseases should be observed carefully after SARS-CoV-2 vaccination." @default.
- W4310859954 created "2022-12-19" @default.
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- W4310859954 date "2022-12-01" @default.
- W4310859954 modified "2023-10-13" @default.
- W4310859954 title "Acute Exacerbation of Interstitial Lung Disease After SARS-CoV-2 Vaccination" @default.
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- W4310859954 doi "https://doi.org/10.1016/j.chest.2022.08.2213" @default.
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