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- W4310860151 abstract "Lactic acid bacteria (LAB) are well known to elicit health benefits in humans, but their functional metabolic landscapes remain unexplored. Here, we analyze differences in growth, intestinal persistence, and postbiotic biosynthesis of six representative LAB and their interactions with 15 gut bacteria under 11 dietary regimes by combining multi-omics and in silico modeling. We confirmed predictions on short-term persistence of LAB and their interactions with commensals using cecal microbiome abundance and spent-medium experiments. Our analyses indicate that probiotic attributes are both diet and species specific and cannot be solely explained using genomics. For example, although both Lacticaseibacillus casei and Lactiplantibacillus plantarum encode similarly sized genomes with diverse capabilities, L. casei exhibits a more desirable phenotype. In addition, high-fat/low-carb diets more likely lead to detrimental outcomes for most LAB. Collectively, our results highlight that probiotics are not one size fits all health supplements and lay the foundation for personalized probiotic design." @default.
- W4310860151 created "2022-12-19" @default.
- W4310860151 creator A5002190584 @default.
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- W4310860151 creator A5074924741 @default.
- W4310860151 date "2022-12-01" @default.
- W4310860151 modified "2023-10-03" @default.
- W4310860151 title "Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet- and strain-specific probiotic idiosyncrasies" @default.
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