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- W4310866745 abstract "Incidence rates of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) are lower but more aggressive in children than in adults due to different biological and host factors. After the clinical application of tyrosine kinase inhibitor (TKI) blocking BCR/ABL kinase activity, the prognosis of children with CML and Ph+ ALL has improved dramatically. Yet, off-target effects and drug tolerance will occur during the TKI treatments, contributing to treatment failure. In addition, compared to adults, children may need a longer course of TKIs therapy, causing detrimental effects on growth and development. In recent years, accumulating evidence indicates that drug resistance and side effects during TKI treatment may result from the cellular metabolism alterations. In this review, we provide a detailed summary of the current knowledge on alterations in metabolic pathways including glucose metabolism, lipid metabolism, amino acid metabolism, and other metabolic processes. In order to obtain better TKI treatment outcomes and avoid side effects, it is essential to understand how the TKIs affect cellular metabolism. Hence, we also discuss the relevance of cellular metabolism in TKIs therapy to provide ideas for better use of TKIs in clinical practice." @default.
- W4310866745 created "2022-12-19" @default.
- W4310866745 creator A5004853400 @default.
- W4310866745 creator A5007638880 @default.
- W4310866745 creator A5018340190 @default.
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- W4310866745 creator A5034363096 @default.
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- W4310866745 creator A5061896134 @default.
- W4310866745 creator A5083174655 @default.
- W4310866745 creator A5090601853 @default.
- W4310866745 date "2022-12-06" @default.
- W4310866745 modified "2023-10-16" @default.
- W4310866745 title "Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children: A review" @default.
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