FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310930489> ?p ?o ?g. }

• W4310930489 abstract "Abstract Background and aims Observational studies have suggested a complex relationship between obesity and multiple sclerosis (MS). However, the role of genetic factors in the comorbidity and whether obesity exist consistent shared genetic relationships with MS, remains unclear. Our study aims to investigate the extent of shared genetic architecture underlying obesity and MS. Methods Based on genome-wide association studies (GWAS) summary statistics, we investigate the genetic correlation by the linkage disequilibrium score regression (LDSC) and genetic covariance analyzer (GNOVA). The casualty was identified by using bidirectional Mendelian randomization. Linkage disequilibrium score regression in specifically expressed genes (LDSC-SEG) and multi-marker analysis of GenoMic annotation (MAGMA) were utilized to investigate single-nucleotide polymorphisms (SNP) enrichment in the tissue and cell-type levels. We then identified shared risk SNPs using cross-trait meta-analyses and Heritability Estimation from Summary Statistics (ρ-HESS). We further explore the potential functional genes for BMI and MS using summary-data-based Mendelian randomization (SMR). Result We found significantly positive genetic correlation and 18 novel shared genetic SNPs were identified in cross-trait meta-analyses. We found the causality of BMI on MS using Mendelian randomization, but slight inconsistent evidence for the causality of MS on BMI. We observed tissue-specific level SNP heritability enrichment for BMI in 9 tissues and MS in 4 tissues, and in cell-type-specific level SNP heritability enrichment 12 consistent cell types were identified for BMI and MS in brain, spleen, lung and whole blood. Conclusion Our study identifies the genetical correlation and shared risk SNPs between BMI and MS. These findings could provide new insights into the etiology of comorbidity and have implications for future therapeutic trials." @default.
• W4310930489 created "2022-12-21" @default.
• W4310930489 creator A5010828798 @default.
• W4310930489 creator A5023539148 @default.
• W4310930489 creator A5024733849 @default.
• W4310930489 creator A5028806190 @default.
• W4310930489 creator A5030880030 @default.
• W4310930489 creator A5035519623 @default.
• W4310930489 creator A5038099037 @default.
• W4310930489 creator A5051746576 @default.
• W4310930489 creator A5065153080 @default.
• W4310930489 creator A5067573287 @default.
• W4310930489 creator A5081589298 @default.
• W4310930489 creator A5088585068 @default.
• W4310930489 date "2022-12-09" @default.
• W4310930489 modified "2023-10-18" @default.
• W4310930489 title "Investigating shared genetic architecture between obesity and multiple sclerosis" @default.
• W4310930489 cites W1502088983 @default.
• W4310930489 cites W1828576284 @default.
• W4310930489 cites W1844405070 @default.
• W4310930489 cites W1902575419 @default.
• W4310930489 cites W1905058580 @default.
• W4310930489 cites W1965732593 @default.
• W4310930489 cites W1987832889 @default.
• W4310930489 cites W2009214062 @default.
• W4310930489 cites W2031397387 @default.
• W4310930489 cites W2033151532 @default.
• W4310930489 cites W2040547343 @default.
• W4310930489 cites W2051314902 @default.
• W4310930489 cites W2051383271 @default.
• W4310930489 cites W2058273950 @default.
• W4310930489 cites W2072789685 @default.
• W4310930489 cites W2104549677 @default.
• W4310930489 cites W2125972459 @default.
• W4310930489 cites W2146921470 @default.
• W4310930489 cites W2152603994 @default.
• W4310930489 cites W2154238224 @default.
• W4310930489 cites W2165184392 @default.
• W4310930489 cites W2166269696 @default.
• W4310930489 cites W2170824762 @default.
• W4310930489 cites W2171548752 @default.
• W4310930489 cites W2171946334 @default.
• W4310930489 cites W2195783463 @default.
• W4310930489 cites W2280070832 @default.
• W4310930489 cites W2324862792 @default.
• W4310930489 cites W2328393125 @default.
• W4310930489 cites W2338291387 @default.
• W4310930489 cites W2419248649 @default.
• W4310930489 cites W2465687223 @default.
• W4310930489 cites W2468326842 @default.
• W4310930489 cites W2531617631 @default.
• W4310930489 cites W2565199748 @default.
• W4310930489 cites W2568117326 @default.
• W4310930489 cites W2591088516 @default.
• W4310930489 cites W2592749475 @default.
• W4310930489 cites W2604218568 @default.
• W4310930489 cites W2611982970 @default.
• W4310930489 cites W2613603864 @default.
• W4310930489 cites W2620344122 @default.
• W4310930489 cites W2625977525 @default.
• W4310930489 cites W2761275051 @default.
• W4310930489 cites W2763645739 @default.
• W4310930489 cites W2780560743 @default.
• W4310930489 cites W2800571132 @default.
• W4310930489 cites W2803072880 @default.
• W4310930489 cites W2889190248 @default.
• W4310930489 cites W2893673243 @default.
• W4310930489 cites W2896352133 @default.
• W4310930489 cites W2911658427 @default.
• W4310930489 cites W2946372752 @default.
• W4310930489 cites W2947254060 @default.
• W4310930489 cites W2949008890 @default.
• W4310930489 cites W2949204661 @default.
• W4310930489 cites W2949693884 @default.
• W4310930489 cites W2950948210 @default.
• W4310930489 cites W2952673268 @default.
• W4310930489 cites W2952882474 @default.
• W4310930489 cites W2952883732 @default.
• W4310930489 cites W2953357410 @default.
• W4310930489 cites W2957675127 @default.
• W4310930489 cites W2976634698 @default.
• W4310930489 cites W2981477552 @default.
• W4310930489 cites W2981873715 @default.
• W4310930489 cites W2987043898 @default.
• W4310930489 cites W2995298170 @default.
• W4310930489 cites W3000676906 @default.
• W4310930489 cites W3009914384 @default.
• W4310930489 cites W3030929194 @default.
• W4310930489 cites W3061084130 @default.
• W4310930489 cites W3092316673 @default.
• W4310930489 cites W3130180415 @default.
• W4310930489 cites W3133859624 @default.
• W4310930489 cites W3176455911 @default.
• W4310930489 cites W3199944448 @default.
• W4310930489 cites W3203284667 @default.
• W4310930489 cites W3208080611 @default.
• W4310930489 cites W4206514399 @default.
• W4310930489 cites W4207047655 @default.
• W4310930489 cites W4223975358 @default.
• W4310930489 cites W4226311577 @default.

• next