FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310938885> ?p ?o ?g. }

• W4310938885 endingPage "35" @default.
• W4310938885 startingPage "30" @default.
• W4310938885 abstract "The splenic endothelial Weibel-palade bodies are one of the most important candidate organelles to release von Willebrand factor upon stimulation with desmopressin. However, the presence of functional desmopressin-specific receptor has not yet been demonstrated on endothelial cells. Experimental evidences are in favour of an indirect pro-haemostatic effect of desmopressin, but the exact mediator and its cellular origin are largely elusive. Here, we report partially hampered desmopressin response in a splenectomised severe haemophilia A/Beta Thalassemia patient without any genetic variant relevant to his incomplete desmopressin response. To further investigate the role of the spleen in this phenomenon, the release of VWF from desmopressin-treated human splenic endothelial cells was assessed in vitro. As a result, desmopressin induced the release of VWF from endothelial cells when the cells were co-cultured with non-classical (CD14dim /CD16++ ), but not other subtypes of monocytes or PBMCs. This in vitro study which resembles close proximity of endothelial cells of sinusoids to monocyte reservoir reside in parenchyma of subcapsular red pulp of the spleen sheds a light upon the role of this highly vascularized VWF-producing organ in driving indirect effect of desmopressin." @default.
• W4310938885 created "2022-12-21" @default.
• W4310938885 creator A5003151316 @default.
• W4310938885 creator A5009814463 @default.
• W4310938885 creator A5032554394 @default.
• W4310938885 creator A5034083394 @default.
• W4310938885 creator A5065472112 @default.
• W4310938885 creator A5066776334 @default.
• W4310938885 creator A5086893441 @default.
• W4310938885 creator A5089630912 @default.
• W4310938885 date "2022-12-07" @default.
• W4310938885 modified "2023-10-16" @default.
• W4310938885 title "Pro‐haemostatic effect of <scp>DDAVP</scp> is partially derived through non‐classical (<scp>CD14^dim</scp>/<scp>CD16</scp>⁺⁺) monocytes residing the spleen" @default.
• W4310938885 cites W125998750 @default.
• W4310938885 cites W177128174 @default.
• W4310938885 cites W1922994469 @default.
• W4310938885 cites W1938044620 @default.
• W4310938885 cites W1965275003 @default.
• W4310938885 cites W1971883718 @default.
• W4310938885 cites W1986402189 @default.
• W4310938885 cites W1999575880 @default.
• W4310938885 cites W2003870922 @default.
• W4310938885 cites W2010239439 @default.
• W4310938885 cites W2020980969 @default.
• W4310938885 cites W2023651730 @default.
• W4310938885 cites W2037508248 @default.
• W4310938885 cites W2038872196 @default.
• W4310938885 cites W2053880485 @default.
• W4310938885 cites W2075507088 @default.
• W4310938885 cites W2096844650 @default.
• W4310938885 cites W2109128853 @default.
• W4310938885 cites W2122067432 @default.
• W4310938885 cites W2129752592 @default.
• W4310938885 cites W2140057203 @default.
• W4310938885 cites W2145864070 @default.
• W4310938885 cites W2152293695 @default.
• W4310938885 cites W2155444336 @default.
• W4310938885 cites W2157210697 @default.
• W4310938885 cites W2289328365 @default.
• W4310938885 cites W2326222521 @default.
• W4310938885 cites W2425535301 @default.
• W4310938885 cites W2781841028 @default.
• W4310938885 cites W2891603793 @default.
• W4310938885 cites W3009111487 @default.
• W4310938885 cites W4254996515 @default.
• W4310938885 cites W4310938885 @default.
• W4310938885 cites W52739331 @default.
• W4310938885 cites W73875704 @default.
• W4310938885 doi "https://doi.org/10.1111/jcmm.17606" @default.
• W4310938885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36479816" @default.
• W4310938885 hasPublicationYear "2022" @default.
• W4310938885 type Work @default.
• W4310938885 citedByCount "1" @default.
• W4310938885 countsByYear W43109388852022 @default.
• W4310938885 crossrefType "journal-article" @default.
• W4310938885 hasAuthorship W4310938885A5003151316 @default.
• W4310938885 hasAuthorship W4310938885A5009814463 @default.
• W4310938885 hasAuthorship W4310938885A5032554394 @default.
• W4310938885 hasAuthorship W4310938885A5034083394 @default.
• W4310938885 hasAuthorship W4310938885A5065472112 @default.
• W4310938885 hasAuthorship W4310938885A5066776334 @default.
• W4310938885 hasAuthorship W4310938885A5086893441 @default.
• W4310938885 hasAuthorship W4310938885A5089630912 @default.
• W4310938885 hasBestOaLocation W43109388851 @default.
• W4310938885 hasConcept C114684123 @default.
• W4310938885 hasConcept C126322002 @default.
• W4310938885 hasConcept C134018914 @default.
• W4310938885 hasConcept C167672396 @default.
• W4310938885 hasConcept C185592680 @default.
• W4310938885 hasConcept C203014093 @default.
• W4310938885 hasConcept C2778513237 @default.
• W4310938885 hasConcept C2778702241 @default.
• W4310938885 hasConcept C2779394231 @default.
• W4310938885 hasConcept C2780931953 @default.
• W4310938885 hasConcept C2781184567 @default.
• W4310938885 hasConcept C2781462264 @default.
• W4310938885 hasConcept C553184892 @default.
• W4310938885 hasConcept C71924100 @default.
• W4310938885 hasConcept C86803240 @default.
• W4310938885 hasConcept C8891405 @default.
• W4310938885 hasConcept C89560881 @default.
• W4310938885 hasConceptScore W4310938885C114684123 @default.
• W4310938885 hasConceptScore W4310938885C126322002 @default.
• W4310938885 hasConceptScore W4310938885C134018914 @default.
• W4310938885 hasConceptScore W4310938885C167672396 @default.
• W4310938885 hasConceptScore W4310938885C185592680 @default.
• W4310938885 hasConceptScore W4310938885C203014093 @default.
• W4310938885 hasConceptScore W4310938885C2778513237 @default.
• W4310938885 hasConceptScore W4310938885C2778702241 @default.
• W4310938885 hasConceptScore W4310938885C2779394231 @default.
• W4310938885 hasConceptScore W4310938885C2780931953 @default.
• W4310938885 hasConceptScore W4310938885C2781184567 @default.
• W4310938885 hasConceptScore W4310938885C2781462264 @default.
• W4310938885 hasConceptScore W4310938885C553184892 @default.
• W4310938885 hasConceptScore W4310938885C71924100 @default.
• W4310938885 hasConceptScore W4310938885C86803240 @default.
• W4310938885 hasConceptScore W4310938885C8891405 @default.
• W4310938885 hasConceptScore W4310938885C89560881 @default.

• next