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- W4310939274 startingPage "897" @default.
- W4310939274 abstract "The renin-angiotensin system (RAS) is an important homeostatic pathway, with emerging evidence for the impact of its components on inflammation and fibrosis in gastrointestinal tissues. This review aims to review current knowledge of the physiological mechanism of RAS in inflammatory bowel disease (IBD), and potential therapeutic implications.An extensive online literature review including Pubmed, Medline, and Google Scholar was undertaken. Discussion on the components of the RAS, localization, and physiological functions in the gastrointestinal tract, preclinical, and clinical data in IBD, and the relation with SARS-Cov-2 are covered in this review.RAS inhibition may have a role as anti-fibrotic adjunct therapy. Targeting the local gastrointestinal RAS with novel modes of delivery may be a target for future therapeutics for IBD, given the widespread availability and safety of current options as utilized in other diseases. Further insight into the mechanism and downstream effects of gastrointestinal ACE2 may lead to a better understanding of the pathogenesis of IBD." @default.
- W4310939274 created "2022-12-21" @default.
- W4310939274 creator A5032091930 @default.
- W4310939274 creator A5038181215 @default.
- W4310939274 creator A5042898422 @default.
- W4310939274 creator A5089027376 @default.
- W4310939274 date "2022-10-03" @default.
- W4310939274 modified "2023-10-17" @default.
- W4310939274 title "What do we know about the renin angiotensin system and inflammatory bowel disease?" @default.
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