Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310940025> ?p ?o ?g. }
- W4310940025 abstract "Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created a global health emergency. However, the underlying pathogenic mechanisms remain elusive. We investigated the host response features of in vivo replication in a mouse model of ZIKV infection, by performing a series of transcriptomic and bioinformatic analyses of ZIKV and mock-infected brain tissue. Tissue damage, inflammatory cells infiltration and high viral replication were observed in the brain tissue of ZIKV infected mice. RNA-Seq of the brain indicated the activation of ferroptosis pathways. Enrichment analysis of ferroptosis regulators revealed their involvement in pathways such as mineral absorption, fatty acid biosynthesis, fatty acid degradation, PPAR signaling pathway, peroxidase, and adipokinesine signalling pathway. We then identified 12 interacted hub ferroptosis regulators (CYBB, HMOX1, CP, SAT1, TF, SLC39A14, FTL, LPCAT3, FTH1, SLC3A2, TP53, and SLC40A1) that were related to the differential expression of CD8+ T cells, microglia and monocytes. CYBB, HMOX1, SALT, and SLAC40A1 were selected as potential biomarkers of ZIKV infection. Finally, we validated our results using RT-qPCR and outside available datasets. For the first time, we proposed a possible mechanism of ferroptosis in brain tissue infected by ZIKV in mice and identified the four key ferroptosis regulators." @default.
- W4310940025 created "2022-12-21" @default.
- W4310940025 creator A5014249983 @default.
- W4310940025 creator A5023294569 @default.
- W4310940025 creator A5027249929 @default.
- W4310940025 creator A5045842763 @default.
- W4310940025 creator A5051525159 @default.
- W4310940025 creator A5051818492 @default.
- W4310940025 creator A5065772307 @default.
- W4310940025 creator A5072671445 @default.
- W4310940025 creator A5078271688 @default.
- W4310940025 creator A5079122443 @default.
- W4310940025 creator A5086485895 @default.
- W4310940025 creator A5087781438 @default.
- W4310940025 creator A5089104038 @default.
- W4310940025 date "2022-12-19" @default.
- W4310940025 modified "2023-09-27" @default.
- W4310940025 title "Transcriptomic reveals the ferroptosis features of host response in a mouse model of Zika virus infection" @default.
- W4310940025 cites W1997183854 @default.
- W4310940025 cites W2053992388 @default.
- W4310940025 cites W2060969557 @default.
- W4310940025 cites W2065934830 @default.
- W4310940025 cites W2072499657 @default.
- W4310940025 cites W2102278945 @default.
- W4310940025 cites W2103017472 @default.
- W4310940025 cites W2104005232 @default.
- W4310940025 cites W2111644571 @default.
- W4310940025 cites W2114104545 @default.
- W4310940025 cites W2130410032 @default.
- W4310940025 cites W2133402546 @default.
- W4310940025 cites W2135882929 @default.
- W4310940025 cites W2159482845 @default.
- W4310940025 cites W2169884072 @default.
- W4310940025 cites W2170551349 @default.
- W4310940025 cites W2281227512 @default.
- W4310940025 cites W2289704315 @default.
- W4310940025 cites W2290748042 @default.
- W4310940025 cites W2293707105 @default.
- W4310940025 cites W2327959547 @default.
- W4310940025 cites W2345638947 @default.
- W4310940025 cites W2442207155 @default.
- W4310940025 cites W2504325655 @default.
- W4310940025 cites W2577798709 @default.
- W4310940025 cites W2586965581 @default.
- W4310940025 cites W2593369312 @default.
- W4310940025 cites W2599624862 @default.
- W4310940025 cites W2607232236 @default.
- W4310940025 cites W2609936523 @default.
- W4310940025 cites W2616772553 @default.
- W4310940025 cites W2745620327 @default.
- W4310940025 cites W2745794351 @default.
- W4310940025 cites W2770282530 @default.
- W4310940025 cites W2778627538 @default.
- W4310940025 cites W2781555529 @default.
- W4310940025 cites W2792953149 @default.
- W4310940025 cites W2801527259 @default.
- W4310940025 cites W2806956641 @default.
- W4310940025 cites W2899808488 @default.
- W4310940025 cites W2945327298 @default.
- W4310940025 cites W2951912016 @default.
- W4310940025 cites W2971720183 @default.
- W4310940025 cites W2977026040 @default.
- W4310940025 cites W2985014963 @default.
- W4310940025 cites W3003712096 @default.
- W4310940025 cites W3004359313 @default.
- W4310940025 cites W3010411405 @default.
- W4310940025 cites W3017165458 @default.
- W4310940025 cites W3022807497 @default.
- W4310940025 cites W3037187659 @default.
- W4310940025 cites W3082539302 @default.
- W4310940025 cites W3092587231 @default.
- W4310940025 cites W3108493784 @default.
- W4310940025 cites W3174052286 @default.
- W4310940025 cites W3195566828 @default.
- W4310940025 cites W3200824944 @default.
- W4310940025 cites W3215365114 @default.
- W4310940025 cites W4200565295 @default.
- W4310940025 cites W4205487044 @default.
- W4310940025 cites W4205879768 @default.
- W4310940025 cites W4213095840 @default.
- W4310940025 cites W4243957837 @default.
- W4310940025 cites W4256409604 @default.
- W4310940025 cites W4281866073 @default.
- W4310940025 cites W4313311892 @default.
- W4310940025 cites W4362015356 @default.
- W4310940025 doi "https://doi.org/10.1002/jmv.28386" @default.
- W4310940025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36477858" @default.
- W4310940025 hasPublicationYear "2022" @default.
- W4310940025 type Work @default.
- W4310940025 citedByCount "2" @default.
- W4310940025 countsByYear W43109400252023 @default.
- W4310940025 crossrefType "journal-article" @default.
- W4310940025 hasAuthorship W4310940025A5014249983 @default.
- W4310940025 hasAuthorship W4310940025A5023294569 @default.
- W4310940025 hasAuthorship W4310940025A5027249929 @default.
- W4310940025 hasAuthorship W4310940025A5045842763 @default.
- W4310940025 hasAuthorship W4310940025A5051525159 @default.
- W4310940025 hasAuthorship W4310940025A5051818492 @default.
- W4310940025 hasAuthorship W4310940025A5065772307 @default.
- W4310940025 hasAuthorship W4310940025A5072671445 @default.