Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310946005> ?p ?o ?g. }
- W4310946005 endingPage "110551" @default.
- W4310946005 startingPage "110551" @default.
- W4310946005 abstract "Skeletal muscle injuries are common, and damaged myofibers are repaired through proliferation and differentiation of muscle satellite cells. GLUT4 is enriched in GLUT4 storage vesicles (GSVs) and plays a crucial role in the maintenance of muscle function. ArfGAP3 regulates the vesicle transport especially for COPI coat assembly, but its effects on GSVs and the repair process after skeletal muscle injury remains unclear. In this study, datasets related to skeletal muscle injury and myoblast differentiation GSE469, GSE5413, GSE45577 and GSE108040 were retrieved through the GEO database and the expression of heptameric coat protein complex I (COPI) and Golgi vesicle transport-related genes in various datasets, as well as the expression correlation between ArfGAP2, ArfGAP3 and COPI-related genes COPA, COPB1, COPB2, COPE, COPZ1, COPZ2 were analyzed. The results suggested that ArfGAP3 was expressed in the process of repair after skeletal muscle injury and myoblast differentiation and that ArfGAP3 was positively correlated with COPI-related genes. In vitro experimental results showed that ArfGAP3 was colocalized with COPA, COPB, COPG protein, and GLUT4 in C2C12 myoblasts. After the downregulation of ArfGAP3 expression, intracellular vesicle transport, and glucose uptake were blocked, the proliferation of myoblasts under low glucose culture conditions was impaired, the proportion of apoptosis increased, and myotube differentiation was impaired. In summary, ArfGAP3 regulates COPI-associated vesicle and GSVs transport and affects the proliferation and differentiation ability of myoblasts by influencing glucose uptake, thereby modulating the repair process after skeletal muscle injury." @default.
- W4310946005 created "2022-12-21" @default.
- W4310946005 creator A5002941097 @default.
- W4310946005 creator A5006799211 @default.
- W4310946005 creator A5019555118 @default.
- W4310946005 creator A5031014530 @default.
- W4310946005 creator A5036016529 @default.
- W4310946005 creator A5056805104 @default.
- W4310946005 creator A5067023840 @default.
- W4310946005 creator A5090625691 @default.
- W4310946005 date "2023-03-01" @default.
- W4310946005 modified "2023-10-15" @default.
- W4310946005 title "ArfGAP3 regulates vesicle transport and glucose uptake in myoblasts" @default.
- W4310946005 cites W1080557924 @default.
- W4310946005 cites W1645918562 @default.
- W4310946005 cites W1857724021 @default.
- W4310946005 cites W1884484468 @default.
- W4310946005 cites W1940760798 @default.
- W4310946005 cites W1971446879 @default.
- W4310946005 cites W1976579206 @default.
- W4310946005 cites W1989699661 @default.
- W4310946005 cites W2003098032 @default.
- W4310946005 cites W2017475690 @default.
- W4310946005 cites W2022144980 @default.
- W4310946005 cites W2035807916 @default.
- W4310946005 cites W2040278595 @default.
- W4310946005 cites W2069152978 @default.
- W4310946005 cites W2072850070 @default.
- W4310946005 cites W2082873926 @default.
- W4310946005 cites W2098436412 @default.
- W4310946005 cites W2099938700 @default.
- W4310946005 cites W2112820831 @default.
- W4310946005 cites W2118286268 @default.
- W4310946005 cites W2118515161 @default.
- W4310946005 cites W2145164437 @default.
- W4310946005 cites W2151238302 @default.
- W4310946005 cites W2152719012 @default.
- W4310946005 cites W2469879809 @default.
- W4310946005 cites W2559655684 @default.
- W4310946005 cites W2719903628 @default.
- W4310946005 cites W2769580895 @default.
- W4310946005 cites W2885031263 @default.
- W4310946005 cites W2919194201 @default.
- W4310946005 cites W2939414276 @default.
- W4310946005 cites W2967714070 @default.
- W4310946005 cites W2995044585 @default.
- W4310946005 cites W3004059569 @default.
- W4310946005 cites W3004804582 @default.
- W4310946005 cites W3018671364 @default.
- W4310946005 cites W3036769478 @default.
- W4310946005 cites W3152848834 @default.
- W4310946005 cites W3196184467 @default.
- W4310946005 doi "https://doi.org/10.1016/j.cellsig.2022.110551" @default.
- W4310946005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36476390" @default.
- W4310946005 hasPublicationYear "2023" @default.
- W4310946005 type Work @default.
- W4310946005 citedByCount "0" @default.
- W4310946005 crossrefType "journal-article" @default.
- W4310946005 hasAuthorship W4310946005A5002941097 @default.
- W4310946005 hasAuthorship W4310946005A5006799211 @default.
- W4310946005 hasAuthorship W4310946005A5019555118 @default.
- W4310946005 hasAuthorship W4310946005A5031014530 @default.
- W4310946005 hasAuthorship W4310946005A5036016529 @default.
- W4310946005 hasAuthorship W4310946005A5056805104 @default.
- W4310946005 hasAuthorship W4310946005A5067023840 @default.
- W4310946005 hasAuthorship W4310946005A5090625691 @default.
- W4310946005 hasConcept C119062480 @default.
- W4310946005 hasConcept C130316041 @default.
- W4310946005 hasConcept C134018914 @default.
- W4310946005 hasConcept C158617107 @default.
- W4310946005 hasConcept C167019083 @default.
- W4310946005 hasConcept C185592680 @default.
- W4310946005 hasConcept C206912223 @default.
- W4310946005 hasConcept C207200792 @default.
- W4310946005 hasConcept C2776188179 @default.
- W4310946005 hasConcept C2777866211 @default.
- W4310946005 hasConcept C2779306644 @default.
- W4310946005 hasConcept C2779959927 @default.
- W4310946005 hasConcept C3763915 @default.
- W4310946005 hasConcept C41625074 @default.
- W4310946005 hasConcept C55493867 @default.
- W4310946005 hasConcept C60278653 @default.
- W4310946005 hasConcept C6492254 @default.
- W4310946005 hasConcept C86803240 @default.
- W4310946005 hasConcept C95444343 @default.
- W4310946005 hasConceptScore W4310946005C119062480 @default.
- W4310946005 hasConceptScore W4310946005C130316041 @default.
- W4310946005 hasConceptScore W4310946005C134018914 @default.
- W4310946005 hasConceptScore W4310946005C158617107 @default.
- W4310946005 hasConceptScore W4310946005C167019083 @default.
- W4310946005 hasConceptScore W4310946005C185592680 @default.
- W4310946005 hasConceptScore W4310946005C206912223 @default.
- W4310946005 hasConceptScore W4310946005C207200792 @default.
- W4310946005 hasConceptScore W4310946005C2776188179 @default.
- W4310946005 hasConceptScore W4310946005C2777866211 @default.
- W4310946005 hasConceptScore W4310946005C2779306644 @default.
- W4310946005 hasConceptScore W4310946005C2779959927 @default.
- W4310946005 hasConceptScore W4310946005C3763915 @default.