FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310946937> ?p ?o ?g. }

• W4310946937 endingPage "362" @default.
• W4310946937 startingPage "353" @default.
• W4310946937 abstract "Detomidine is an α-2 agonist sedative drug which reduces the release of norepinephrine in nerves. Administering this drug through intranasal (IN) route could cause direct transmission to the central nervous system. Therefore, IN administration of detomidine would decrease the side effects and the onset of sedation.In this study, IN administration of detomidine in sheep through an atomiser was compared to its IV administration.Fifteen mature female sheep with an approximate weight of 49.53 ± 1.72 kg were used. They were randomly divided into three groups: (1) atomising 10 μg/kg (IND10 ); (2) IV 10 μg/kg (IVD) and (3) atomising 30 μg/kg (IND30 ). Following administration, vital signs, electrocardiographic components, sedative score and biochemistry profile were measured after 15, 30 and 60 min, which were compared with the baseline measures.Bradycardia and the percentage of reduction from the baseline value in the respiratory rate were lower in the IND10 group compared to those in the IVD group. There was no significant difference in terms of the temperature and blood oxygen saturation (SpO2 ) among all the groups (p > 0.05). The level of cortisol declined in all the groups, and in the IND30 (60 min), it was significantly different with the baseline value. The level of glucose increased in all the groups compared to the baseline, which was not significant. Insulin concentration was reduced in all the groups, and in the IND30 group, it changed significantly 60 min after the drug administration. Sedation onset time was faster in the IV group. However, sedation scores between the two administration methods were not different, and only a dose-dependent increase was found in the sedation score in the atomisation group.Our findings revealed that IN atomisation of detomidine triggers similar sedation as its IV administration, which could be used as an alternative method." @default.
• W4310946937 created "2022-12-21" @default.
• W4310946937 creator A5012318799 @default.
• W4310946937 creator A5040215805 @default.
• W4310946937 creator A5051613055 @default.
• W4310946937 creator A5060395885 @default.
• W4310946937 date "2022-12-08" @default.
• W4310946937 modified "2023-09-30" @default.
• W4310946937 title "Comparing the effects of intravenous injection and intranasal atomisation of detomidine in sheep" @default.
• W4310946937 cites W150485264 @default.
• W4310946937 cites W1556466550 @default.
• W4310946937 cites W1559040908 @default.
• W4310946937 cites W1709262067 @default.
• W4310946937 cites W1917854314 @default.
• W4310946937 cites W1968362351 @default.
• W4310946937 cites W2028981805 @default.
• W4310946937 cites W2054195916 @default.
• W4310946937 cites W2055930558 @default.
• W4310946937 cites W2075002047 @default.
• W4310946937 cites W2092083886 @default.
• W4310946937 cites W2122342407 @default.
• W4310946937 cites W2148541790 @default.
• W4310946937 cites W2153955877 @default.
• W4310946937 cites W2162752807 @default.
• W4310946937 cites W2170138193 @default.
• W4310946937 cites W2196359766 @default.
• W4310946937 cites W2591968194 @default.
• W4310946937 cites W2604185023 @default.
• W4310946937 cites W2609434513 @default.
• W4310946937 cites W2623614440 @default.
• W4310946937 cites W2792671845 @default.
• W4310946937 cites W2953342669 @default.
• W4310946937 cites W2965648093 @default.
• W4310946937 cites W3000741634 @default.
• W4310946937 cites W3047879827 @default.
• W4310946937 cites W4220866562 @default.
• W4310946937 cites W4238754411 @default.
• W4310946937 cites W4310946937 @default.
• W4310946937 doi "https://doi.org/10.1002/vms3.1023" @default.
• W4310946937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36480453" @default.
• W4310946937 hasPublicationYear "2022" @default.
• W4310946937 type Work @default.
• W4310946937 citedByCount "1" @default.
• W4310946937 countsByYear W43109469372022 @default.
• W4310946937 crossrefType "journal-article" @default.
• W4310946937 hasAuthorship W4310946937A5012318799 @default.
• W4310946937 hasAuthorship W4310946937A5040215805 @default.
• W4310946937 hasAuthorship W4310946937A5051613055 @default.
• W4310946937 hasAuthorship W4310946937A5060395885 @default.
• W4310946937 hasBestOaLocation W43109469371 @default.
• W4310946937 hasConcept C126322002 @default.
• W4310946937 hasConcept C2776812421 @default.
• W4310946937 hasConcept C2776814716 @default.
• W4310946937 hasConcept C2777495988 @default.
• W4310946937 hasConcept C2777602617 @default.
• W4310946937 hasConcept C2777953023 @default.
• W4310946937 hasConcept C42219234 @default.
• W4310946937 hasConcept C71924100 @default.
• W4310946937 hasConcept C84393581 @default.
• W4310946937 hasConcept C85663871 @default.
• W4310946937 hasConcept C98274493 @default.
• W4310946937 hasConceptScore W4310946937C126322002 @default.
• W4310946937 hasConceptScore W4310946937C2776812421 @default.
• W4310946937 hasConceptScore W4310946937C2776814716 @default.
• W4310946937 hasConceptScore W4310946937C2777495988 @default.
• W4310946937 hasConceptScore W4310946937C2777602617 @default.
• W4310946937 hasConceptScore W4310946937C2777953023 @default.
• W4310946937 hasConceptScore W4310946937C42219234 @default.
• W4310946937 hasConceptScore W4310946937C71924100 @default.
• W4310946937 hasConceptScore W4310946937C84393581 @default.
• W4310946937 hasConceptScore W4310946937C85663871 @default.
• W4310946937 hasConceptScore W4310946937C98274493 @default.
• W4310946937 hasIssue "1" @default.
• W4310946937 hasLocation W43109469371 @default.
• W4310946937 hasLocation W43109469372 @default.
• W4310946937 hasLocation W43109469373 @default.
• W4310946937 hasOpenAccess W4310946937 @default.
• W4310946937 hasPrimaryLocation W43109469371 @default.
• W4310946937 hasRelatedWork W2126545071 @default.
• W4310946937 hasRelatedWork W2159660533 @default.
• W4310946937 hasRelatedWork W2181650405 @default.
• W4310946937 hasRelatedWork W2359780091 @default.
• W4310946937 hasRelatedWork W2417303756 @default.
• W4310946937 hasRelatedWork W2520630385 @default.
• W4310946937 hasRelatedWork W2604185023 @default.
• W4310946937 hasRelatedWork W3028683756 @default.
• W4310946937 hasRelatedWork W4310946937 @default.
• W4310946937 hasRelatedWork W2596079502 @default.
• W4310946937 hasVolume "9" @default.
• W4310946937 isParatext "false" @default.
• W4310946937 isRetracted "false" @default.
• W4310946937 workType "article" @default.