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• W4310954684 abstract "Abstract Objectives The definitive diagnosis of tuberculous meningitis (TBM) is achieved by identifying Mycobacterium tuberculosis (MTb) in cerebrospinal fluid (CSF); however, diagnostic confirmation is difficult due to the inability of current tests for an effective diagnosis. Our objective was to retrospectively assess the characteristics of CSF lactate (CSF-LA) as an adjunct biomarker in the diagnosis of TBM. Methods 608 CSF laboratory reports were assessed. Of these, 560 had clinically suspected TBM. These were classified as definite (n=36), probable (23), possible (278), or non-TBM (223) according to the international consensus TBM case definitions. An additional 48 CSF samples were negative controls with normal CSF. Results Against a reference standard of definite TBM, the cut-off value for CSF-LA was 4.0 mmol/L, the area under the ROC curve was 0.88 (95% CI, 0.82–0.94; p=0.0001), sensitivity was 69%, specificity 90%, negative predictive value 98%. These diagnostic parameters decreased when calculated against those of the other categories of TBM. CSF-LA exhibited high specificity, efficiency, negative predictive value, and clinical utility index in all the groups studied. Conclusions CSF-LA is a useful diagnostic marker to rule out TBM when associated with conventional microbiology tests, nucleic acid amplification assays, and clinical algorithms, particularly in endemic areas." @default.
• W4310954684 created "2022-12-21" @default.
• W4310954684 creator A5013692275 @default.
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• W4310954684 date "2022-12-08" @default.
• W4310954684 modified "2023-09-29" @default.
• W4310954684 title "Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis" @default.
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• W4310954684 doi "https://doi.org/10.1515/dx-2022-0102" @default.
• W4310954684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36476307" @default.
• W4310954684 hasPublicationYear "2022" @default.
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