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• W4310955585 abstract "Abstract We aimed to assess the glucose and lactate kinetics during therapeutic hypothermia (TH) in infants with hypoxic-ischemic encephalopathy and its relationship with longitudinal neurodevelopment. We measured glucose and lactate concentrations before TH and on days 2 and 3 in infants with mild, moderate, and severe hypoxic-ischemic encephalopathy (HIE). Neurodevelopment was assessed at 2 years. Participants were grouped according to the neurodevelopmental outcome into favorable (FO) or unfavorable (UFO). Eighty-eight infants were evaluated at follow-up, 34 for the FO and 54 for the UFO group. Severe hypo- (< 2.6 mmol/L) and hyperglycemia (> 10 mmol/L) occurred in 18% and 36% from the FO and UFO groups, respectively. Glucose-to-lactate ratio on day 1 was the strongest predictor of unfavorable metabolic outcome (OR 3.27 $$pm$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mo>±</mml:mo> </mml:math> 1.81, p = 0.032) when adjusted for other clinical and metabolic variables, including Sarnat score. Conclusion : Glucose-to-lactate ratio on day 1 may represent a new risk marker for infants with HIE undergoing TH. What is Known: • Glucose and lactate are key metabolic fuels during neonatal hypoglycemia. This suggests that their concentrations may influence the neurodevelopmental outcome of neonates experiencing hypoxic-hischemic encephalopathy (HIE). What is New: • We describe the relative availbility of glucose and lactate before and during theraputic hypothermia in neonates with HIE." @default.
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• W4310955585 date "2022-12-09" @default.
• W4310955585 modified "2023-09-24" @default.
• W4310955585 title "Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study" @default.
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• W4310955585 doi "https://doi.org/10.1007/s00431-022-04694-3" @default.
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