Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310960180> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4310960180 abstract "Abstract Background Obesity is a chronic disease with rising prevalence. Guidelines suggest medications for obesity management if lifestyle interventions do not lead to substantial weight loss. Randomized control trials have shown the efficacy of anti-obesity medications in inducing weight loss, but real-world data are lacking. Therefore, our study aims to evaluate anti-obesity medications’ effectiveness in reducing weight and improving cardiometabolic parameters and to assess their persistence in a real-world setting. Methods A historical cohort study using routinely collected data from Clalit Health Services (CHS). We retrieved data on all CHS members aged ≥20 years who initiated anti-obesity medication (orlistat, liraglutide 3 mg, and lorcaserin) between 2018 and 2020. We assessed average weight loss and the percentage of patients that had lost ≥5% and ≥10% of their body weight at 3, 6, and 9 months and compared the effectiveness of these 3 medications. Results We included 5,306 CHS members in our study; most (77.8%) were female, aged 40–59 years (52.4%). Treatment with liraglutide 3 mg and lorcaserin was associated with subsequent weight reduction. The average weight loss at 6 months was 5.6 kg (4.95–6.25, 95% confidence interval [CI]) with liraglutide 3 mg and 1.7 kg (1.2–2.2, 95% CI) with lorcaserin. There was no evidence that treatment with orlistat was associated with subsequent weight loss (−0.18 kg [−0.8 to 0.4, 95% CI]). At 6 months, 38% of the patients with orlistat, 43% with lorcaserin, and 51% with liraglutide 3 mg persisted with their treatments (P < 0.001). Conclusion Liraglutide 3 mg was the primary medication associated with clinically significant weight loss and had the highest persistence rate in our real-world study." @default.
- W4310960180 created "2022-12-21" @default.
- W4310960180 creator A5021736196 @default.
- W4310960180 creator A5029266042 @default.
- W4310960180 creator A5029671015 @default.
- W4310960180 date "2022-12-08" @default.
- W4310960180 modified "2023-09-29" @default.
- W4310960180 title "Effectiveness and persistence of anti-obesity medications (liraglutide 3 mg, lorcaserin, and orlistat) in a real-world primary care setting" @default.
- W4310960180 cites W1596168891 @default.
- W4310960180 cites W1918701009 @default.
- W4310960180 cites W1978585499 @default.
- W4310960180 cites W2096048424 @default.
- W4310960180 cites W2097309757 @default.
- W4310960180 cites W2115854144 @default.
- W4310960180 cites W2134860420 @default.
- W4310960180 cites W2136335834 @default.
- W4310960180 cites W2148287957 @default.
- W4310960180 cites W2151436226 @default.
- W4310960180 cites W2156363246 @default.
- W4310960180 cites W2157135485 @default.
- W4310960180 cites W2341244791 @default.
- W4310960180 cites W2394582105 @default.
- W4310960180 cites W2613114070 @default.
- W4310960180 cites W2616921353 @default.
- W4310960180 cites W2735376054 @default.
- W4310960180 cites W2762208322 @default.
- W4310960180 cites W2774597464 @default.
- W4310960180 cites W2869547625 @default.
- W4310960180 cites W2888060992 @default.
- W4310960180 cites W2888628330 @default.
- W4310960180 cites W2905747476 @default.
- W4310960180 cites W2913427490 @default.
- W4310960180 cites W2913874542 @default.
- W4310960180 cites W2944619570 @default.
- W4310960180 cites W2953705715 @default.
- W4310960180 cites W2967788962 @default.
- W4310960180 cites W3037683713 @default.
- W4310960180 cites W3084409364 @default.
- W4310960180 cites W3131688063 @default.
- W4310960180 cites W3193387990 @default.
- W4310960180 cites W3193955443 @default.
- W4310960180 cites W3217240228 @default.
- W4310960180 cites W807162506 @default.
- W4310960180 doi "https://doi.org/10.1093/fampra/cmac141" @default.
- W4310960180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36477550" @default.
- W4310960180 hasPublicationYear "2022" @default.
- W4310960180 type Work @default.
- W4310960180 citedByCount "0" @default.
- W4310960180 crossrefType "journal-article" @default.
- W4310960180 hasAuthorship W4310960180A5021736196 @default.
- W4310960180 hasAuthorship W4310960180A5029266042 @default.
- W4310960180 hasAuthorship W4310960180A5029671015 @default.
- W4310960180 hasConcept C126322002 @default.
- W4310960180 hasConcept C134018914 @default.
- W4310960180 hasConcept C2777180221 @default.
- W4310960180 hasConcept C2780586474 @default.
- W4310960180 hasConcept C2780780548 @default.
- W4310960180 hasConcept C2781308992 @default.
- W4310960180 hasConcept C44249647 @default.
- W4310960180 hasConcept C511355011 @default.
- W4310960180 hasConcept C544821477 @default.
- W4310960180 hasConcept C555293320 @default.
- W4310960180 hasConcept C71924100 @default.
- W4310960180 hasConceptScore W4310960180C126322002 @default.
- W4310960180 hasConceptScore W4310960180C134018914 @default.
- W4310960180 hasConceptScore W4310960180C2777180221 @default.
- W4310960180 hasConceptScore W4310960180C2780586474 @default.
- W4310960180 hasConceptScore W4310960180C2780780548 @default.
- W4310960180 hasConceptScore W4310960180C2781308992 @default.
- W4310960180 hasConceptScore W4310960180C44249647 @default.
- W4310960180 hasConceptScore W4310960180C511355011 @default.
- W4310960180 hasConceptScore W4310960180C544821477 @default.
- W4310960180 hasConceptScore W4310960180C555293320 @default.
- W4310960180 hasConceptScore W4310960180C71924100 @default.
- W4310960180 hasLocation W43109601801 @default.
- W4310960180 hasLocation W43109601802 @default.
- W4310960180 hasOpenAccess W4310960180 @default.
- W4310960180 hasPrimaryLocation W43109601801 @default.
- W4310960180 hasRelatedWork W199595286 @default.
- W4310960180 hasRelatedWork W2060979843 @default.
- W4310960180 hasRelatedWork W2098994326 @default.
- W4310960180 hasRelatedWork W2326472111 @default.
- W4310960180 hasRelatedWork W2967788962 @default.
- W4310960180 hasRelatedWork W4213302520 @default.
- W4310960180 hasRelatedWork W4283796061 @default.
- W4310960180 hasRelatedWork W4293073886 @default.
- W4310960180 hasRelatedWork W4310960180 @default.
- W4310960180 hasRelatedWork W4319657262 @default.
- W4310960180 isParatext "false" @default.
- W4310960180 isRetracted "false" @default.
- W4310960180 workType "article" @default.