Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310963102> ?p ?o ?g. }
- W4310963102 endingPage "1271" @default.
- W4310963102 startingPage "1256" @default.
- W4310963102 abstract "Discovering why some people's cognitive abilities decline more than others is a key challenge for cognitive ageing research. The most effective strategy may be to address multiple risk factors from across the life-course simultaneously in relation to robust longitudinal cognitive data. We conducted a 12-year follow-up of 1091 (at age 70) men and women from the longitudinal Lothian Birth Cohort 1936 study. Comprehensive repeated cognitive measures of visuospatial ability, processing speed, memory, verbal ability, and a general cognitive factor were collected over five assessments (age 70, 73, 76, 79, and 82 years) and analysed using multivariate latent growth curve modelling. Fifteen life-course variables were used to predict variation in cognitive ability levels at age 70 and cognitive slopes from age 70 to 82. Only APOE e4 carrier status was found to be reliably informative of general- and domain-specific cognitive decline, despite there being many life-course correlates of cognitive level at age 70. APOE e4 carriers had significantly steeper slopes across all three fluid cognitive domains compared with non-carriers, especially for memory (β = -0.234, p < 0.001) and general cognitive function (β = -0.246, p < 0.001), denoting a widening gap in cognitive functioning with increasing age. Our findings suggest that when many other candidate predictors of cognitive ageing slope are entered en masse, their unique contributions account for relatively small proportions of variance, beyond variation in APOE e4 status. We conclude that APOE e4 status is important for identifying those at greater risk for accelerated cognitive ageing, even among ostensibly healthy individuals." @default.
- W4310963102 created "2022-12-21" @default.
- W4310963102 creator A5018311376 @default.
- W4310963102 creator A5037656149 @default.
- W4310963102 creator A5048996236 @default.
- W4310963102 creator A5049892384 @default.
- W4310963102 creator A5054787746 @default.
- W4310963102 creator A5057522833 @default.
- W4310963102 creator A5065331652 @default.
- W4310963102 creator A5088031899 @default.
- W4310963102 date "2022-12-08" @default.
- W4310963102 modified "2023-10-18" @default.
- W4310963102 title "Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: the Lothian Birth Cohort 1936" @default.
- W4310963102 cites W1511433496 @default.
- W4310963102 cites W1527171303 @default.
- W4310963102 cites W1534775837 @default.
- W4310963102 cites W177281196 @default.
- W4310963102 cites W1845447069 @default.
- W4310963102 cites W1847168837 @default.
- W4310963102 cites W1871783318 @default.
- W4310963102 cites W1913957972 @default.
- W4310963102 cites W1974447956 @default.
- W4310963102 cites W1975096655 @default.
- W4310963102 cites W1980858895 @default.
- W4310963102 cites W1984737558 @default.
- W4310963102 cites W1991044584 @default.
- W4310963102 cites W1999434840 @default.
- W4310963102 cites W2005739466 @default.
- W4310963102 cites W2008854521 @default.
- W4310963102 cites W2009339691 @default.
- W4310963102 cites W2029861863 @default.
- W4310963102 cites W2032860338 @default.
- W4310963102 cites W2038193768 @default.
- W4310963102 cites W2039752037 @default.
- W4310963102 cites W2041643367 @default.
- W4310963102 cites W2042240757 @default.
- W4310963102 cites W2047939342 @default.
- W4310963102 cites W2053643060 @default.
- W4310963102 cites W2057852669 @default.
- W4310963102 cites W2058161128 @default.
- W4310963102 cites W2059615097 @default.
- W4310963102 cites W2067975928 @default.
- W4310963102 cites W2070929636 @default.
- W4310963102 cites W2072738413 @default.
- W4310963102 cites W2075312072 @default.
- W4310963102 cites W2075402786 @default.
- W4310963102 cites W2079871836 @default.
- W4310963102 cites W2091041552 @default.
- W4310963102 cites W2099886355 @default.
- W4310963102 cites W2103018327 @default.
- W4310963102 cites W2103898616 @default.
- W4310963102 cites W2112957305 @default.
- W4310963102 cites W2114277576 @default.
- W4310963102 cites W2115620754 @default.
- W4310963102 cites W2125740150 @default.
- W4310963102 cites W2126615789 @default.
- W4310963102 cites W2128426484 @default.
- W4310963102 cites W2130713892 @default.
- W4310963102 cites W2131298552 @default.
- W4310963102 cites W2132674474 @default.
- W4310963102 cites W2140575485 @default.
- W4310963102 cites W2140718540 @default.
- W4310963102 cites W2143047222 @default.
- W4310963102 cites W2145336227 @default.
- W4310963102 cites W2148027524 @default.
- W4310963102 cites W2148080316 @default.
- W4310963102 cites W2156811997 @default.
- W4310963102 cites W2162648764 @default.
- W4310963102 cites W2164018083 @default.
- W4310963102 cites W2164674372 @default.
- W4310963102 cites W2165981731 @default.
- W4310963102 cites W2166281097 @default.
- W4310963102 cites W2167311298 @default.
- W4310963102 cites W2169042012 @default.
- W4310963102 cites W2171776652 @default.
- W4310963102 cites W2184666202 @default.
- W4310963102 cites W2266056865 @default.
- W4310963102 cites W2311427096 @default.
- W4310963102 cites W2346610463 @default.
- W4310963102 cites W2518774723 @default.
- W4310963102 cites W2622458277 @default.
- W4310963102 cites W2782975316 @default.
- W4310963102 cites W2789208440 @default.
- W4310963102 cites W2791231581 @default.
- W4310963102 cites W2802395378 @default.
- W4310963102 cites W2887398816 @default.
- W4310963102 cites W2887615791 @default.
- W4310963102 cites W2889677374 @default.
- W4310963102 cites W2892865933 @default.
- W4310963102 cites W2897096718 @default.
- W4310963102 cites W2900302187 @default.
- W4310963102 cites W2919872768 @default.
- W4310963102 cites W2953355190 @default.
- W4310963102 cites W2989725521 @default.
- W4310963102 cites W2992862671 @default.
- W4310963102 cites W2996808820 @default.
- W4310963102 cites W2997277858 @default.
- W4310963102 cites W3033301946 @default.