Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310963914> ?p ?o ?g. }
- W4310963914 abstract "The large diversity of cell types in nervous systems presents a challenge in identifying the genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the Drosophila visual system can each be defined by unique combinations of on average 10 continuously expressed transcription factors. We show that targeted modifications of this terminal selector code induce predictable conversions of neuronal fates that appear morphologically and transcriptionally complete. Cis-regulatory analysis of open chromatin links one of these genes to an upstream patterning factor that specifies neuronal fates in stem cells. Experimentally validated network models describe the synergistic regulation of downstream effectors by terminal selectors and ecdysone signaling during brain wiring. Our results provide a generalizable framework of how specific fates are implemented in postmitotic neurons." @default.
- W4310963914 created "2022-12-21" @default.
- W4310963914 creator A5037811567 @default.
- W4310963914 creator A5054283956 @default.
- W4310963914 creator A5055203249 @default.
- W4310963914 creator A5061033505 @default.
- W4310963914 creator A5075052493 @default.
- W4310963914 creator A5087540278 @default.
- W4310963914 date "2022-12-23" @default.
- W4310963914 modified "2023-10-16" @default.
- W4310963914 title "Coordinated control of neuronal differentiation and wiring by sustained transcription factors" @default.
- W4310963914 cites W1491075702 @default.
- W4310963914 cites W1564340322 @default.
- W4310963914 cites W1675962022 @default.
- W4310963914 cites W1969353942 @default.
- W4310963914 cites W1979494152 @default.
- W4310963914 cites W1983659582 @default.
- W4310963914 cites W1987167495 @default.
- W4310963914 cites W1989613239 @default.
- W4310963914 cites W2000070336 @default.
- W4310963914 cites W2006067904 @default.
- W4310963914 cites W2014988811 @default.
- W4310963914 cites W2026833123 @default.
- W4310963914 cites W2027788106 @default.
- W4310963914 cites W2040107912 @default.
- W4310963914 cites W2046609126 @default.
- W4310963914 cites W2048214479 @default.
- W4310963914 cites W2059263766 @default.
- W4310963914 cites W2063206483 @default.
- W4310963914 cites W2072712583 @default.
- W4310963914 cites W2073800978 @default.
- W4310963914 cites W2079135431 @default.
- W4310963914 cites W2083852770 @default.
- W4310963914 cites W2111974989 @default.
- W4310963914 cites W2118652401 @default.
- W4310963914 cites W2120525124 @default.
- W4310963914 cites W2123850480 @default.
- W4310963914 cites W2133914326 @default.
- W4310963914 cites W2140952049 @default.
- W4310963914 cites W2156661861 @default.
- W4310963914 cites W2162552502 @default.
- W4310963914 cites W2163398664 @default.
- W4310963914 cites W2174398926 @default.
- W4310963914 cites W2218429564 @default.
- W4310963914 cites W2233667683 @default.
- W4310963914 cites W2335532405 @default.
- W4310963914 cites W2579394006 @default.
- W4310963914 cites W2614869190 @default.
- W4310963914 cites W2620827867 @default.
- W4310963914 cites W2732659948 @default.
- W4310963914 cites W2777715135 @default.
- W4310963914 cites W2791731597 @default.
- W4310963914 cites W2795397420 @default.
- W4310963914 cites W2888236541 @default.
- W4310963914 cites W2897707283 @default.
- W4310963914 cites W2910337627 @default.
- W4310963914 cites W2910417784 @default.
- W4310963914 cites W2920342605 @default.
- W4310963914 cites W2949177718 @default.
- W4310963914 cites W2949509738 @default.
- W4310963914 cites W2999498932 @default.
- W4310963914 cites W3005351790 @default.
- W4310963914 cites W3012412548 @default.
- W4310963914 cites W3040191426 @default.
- W4310963914 cites W3042079122 @default.
- W4310963914 cites W3065112399 @default.
- W4310963914 cites W3095662667 @default.
- W4310963914 cites W3095762353 @default.
- W4310963914 cites W3110998204 @default.
- W4310963914 cites W3164692211 @default.
- W4310963914 cites W3176762080 @default.
- W4310963914 cites W3210860076 @default.
- W4310963914 cites W4205345182 @default.
- W4310963914 cites W4206957602 @default.
- W4310963914 cites W4212960115 @default.
- W4310963914 cites W4213111299 @default.
- W4310963914 cites W4224094774 @default.
- W4310963914 doi "https://doi.org/10.1126/science.add1884" @default.
- W4310963914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36480601" @default.
- W4310963914 hasPublicationYear "2022" @default.
- W4310963914 type Work @default.
- W4310963914 citedByCount "5" @default.
- W4310963914 countsByYear W43109639142021 @default.
- W4310963914 countsByYear W43109639142023 @default.
- W4310963914 crossrefType "journal-article" @default.
- W4310963914 hasAuthorship W4310963914A5037811567 @default.
- W4310963914 hasAuthorship W4310963914A5054283956 @default.
- W4310963914 hasAuthorship W4310963914A5055203249 @default.
- W4310963914 hasAuthorship W4310963914A5061033505 @default.
- W4310963914 hasAuthorship W4310963914A5075052493 @default.
- W4310963914 hasAuthorship W4310963914A5087540278 @default.
- W4310963914 hasBestOaLocation W43109639141 @default.
- W4310963914 hasConcept C104317684 @default.
- W4310963914 hasConcept C148738053 @default.
- W4310963914 hasConcept C169760540 @default.
- W4310963914 hasConcept C51785407 @default.
- W4310963914 hasConcept C54355233 @default.
- W4310963914 hasConcept C66746571 @default.
- W4310963914 hasConcept C70721500 @default.
- W4310963914 hasConcept C83640560 @default.