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- W4310973715 abstract "Abstract Background Maternal depression and anxiety may increase the risk of offspring incontinence; however, current evidence is unable to draw causal inferences. This study aimed to examine prospective associations between maternal psychopathology and offspring incontinence/constipation and examine evidence for causal intra-uterine effects. Methods The study used data from 6,489 children from the Avon Longitudinal Study of Parents and Children. Mothers provided data on depression and anxiety (antenatal and postnatal) and their child’s incontinence (daytime wetting, bedwetting, soiling) and constipation at age 7. We used multivariable logistic regression to examine evidence for independent effects of maternal depression/anxiety on offspring incontinence/constipation and explore a critical/sensitive period of exposure. A negative control design was utilised to examine evidence causal intra-uterine effects. Results Postnatal maternal psychopathology was associated with an increased risk of offspring incontinence and constipation (e.g. postnatal anxiety and daytime wetting OR: 1.53; 95% CI: 1.21-1.94), and data were consistent with a critical period model. There was evidence for an independent effect of maternal anxiety. Antenatal maternal psychopathology was associated with constipation (e.g. antenatal anxiety OR: 1.57; 95% CI: 1.25-1.98), but there was no evidence for a causal intra-uterine effect. Limitations Attrition and maternal reports without use of established diagnostic criteria for incontinence/constipation are potential limitations. Conclusions Children exposed to maternal postnatal psychopathology had a greater risk of incontinence/constipation, and maternal anxiety had stronger associations than depression." @default.
- W4310973715 created "2022-12-21" @default.
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- W4310973715 date "2022-12-07" @default.
- W4310973715 modified "2023-10-14" @default.
- W4310973715 title "The relationship between maternal psychopathology and offspring incontinence and constipation at school age: a prospective cohort study" @default.
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- W4310973715 doi "https://doi.org/10.1101/2022.12.07.22283220" @default.
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