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• W4310985709 abstract "Organoids are in vitro cellular collectives from which, for example, brain-like, or gut-like, or kidney-like structures emerge. To make quantitative predictions regarding the morphology and rheology of a cellular collective in its initial stages of development, we construct and study a three-dimensional vertex model. In such a model, the cells are represented as deformable polyhedrons with cells sharing faces such that there are no gaps between them, otherwise known as confluent. In a bulk model with periodic boundary conditions, we find a rigidity transition as a function of the target cell shape index ${s}_{0}$ with a critical value ${s}_{0}^{*}=5.39ifmmodepmelsetextpmfi{}0.01$. For a confluent cellular collective with a finite boundary, and in the presence of lateral extensile and in-plane, radial extensile deformations, we find a significant boundary-bulk effect that is one-cell layer thick. More specifically, for lateral extensile deformations, the cells in the bulk are much less aligned with the direction of the lateral deformation than the cells at the boundary. For in-plane, radial deformations, the cells in the bulk exhibit much less reorientation perpendicular to the radial direction than the cells at the boundary. In other words, for both deformations, the bulk, interior cells are topologically protected from the deformations, at least over time scales much slower than the timescale for cellular rearrangements and up to reasonable amounts of strain. Our results provide an underlying mechanism for some observed cell shape patterning in organoids and in in vivo settings. Finally, we discuss the use of a cellular-based approach to designing organoids with new types of morphologies to study the intricate relationship between structure and function at the multicellular scale." @default.
• W4310985709 created "2022-12-22" @default.
• W4310985709 creator A5025194168 @default.
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• W4310985709 date "2022-11-29" @default.
• W4310985709 modified "2023-09-30" @default.
• W4310985709 title "Topologically-protected interior for three-dimensional confluent cellular collectives" @default.
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• W4310985709 doi "https://doi.org/10.1103/physrevresearch.4.043148" @default.
• W4310985709 hasPublicationYear "2022" @default.
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