FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310995087> ?p ?o ?g. }

• W4310995087 abstract "Abstract Oligoribonuclease (Orn) of P. aeruginosa is a highly conserved exonuclease, which can regulate the global gene expression levels of bacteria through regulation of both the nanoRNA and c-di-GMP. NanoRNA can regulate the expression of the bacterial global genome as a transcription initiator, and c-di-GMP is the most widely second messenger in bacterial cells. This study seeks to elucidate on the regulation of orn on pathogenicity of P. aeruginosa . P. aeruginosa with orn deletion was constructed by suicide plasmid homologous recombination method. The possible regulatory process of orn was analyzed by TMT quantitative labeling proteomics. Then experiments were conducted to verify the changes of Δ orn on bacterial motility, virulence and biofilm formation. Bacterial pathogenicity was further detected in cell and animal skin trauma models. ELISA detection c-di-GMP concentration and colony aggregation and biofilm formation were observed by scanning electron microscope. orn deletion changed the global metabolism of P. aeruginosa and reduced intracellular energy metabolism. It leads to the disorder of the quorum sensing system, the reduction of bacterial motility and virulence factors pyocyanin and rhamnolipids. But, orn deletion enhanced pathogenicity in vitro and in vivo, a high level of c-di-GMP and biofilm development of P. aeruginosa . Orn regulates the ability of P. aeruginosa to adapt to the external environment" @default.
• W4310995087 created "2022-12-22" @default.
• W4310995087 creator A5023492006 @default.
• W4310995087 creator A5025752244 @default.
• W4310995087 creator A5031456893 @default.
• W4310995087 creator A5046140141 @default.
• W4310995087 creator A5076679983 @default.
• W4310995087 date "2022-11-29" @default.
• W4310995087 modified "2023-09-30" @default.
• W4310995087 title "Oligoribonuclease mediates high adaptability of P. aeruginosa through metabolic conversion" @default.
• W4310995087 cites W1842766745 @default.
• W4310995087 cites W1858850920 @default.
• W4310995087 cites W1977938958 @default.
• W4310995087 cites W1999894502 @default.
• W4310995087 cites W2000461931 @default.
• W4310995087 cites W2027238283 @default.
• W4310995087 cites W2035628814 @default.
• W4310995087 cites W2075287054 @default.
• W4310995087 cites W2095415260 @default.
• W4310995087 cites W2113771246 @default.
• W4310995087 cites W2120480197 @default.
• W4310995087 cites W2124439712 @default.
• W4310995087 cites W2136143897 @default.
• W4310995087 cites W2152858686 @default.
• W4310995087 cites W2159516908 @default.
• W4310995087 cites W2163700728 @default.
• W4310995087 cites W2168755417 @default.
• W4310995087 cites W2171331783 @default.
• W4310995087 cites W2346813136 @default.
• W4310995087 cites W2425261276 @default.
• W4310995087 cites W2623070739 @default.
• W4310995087 cites W2758396470 @default.
• W4310995087 cites W2766761875 @default.
• W4310995087 cites W2776978775 @default.
• W4310995087 cites W2796472927 @default.
• W4310995087 cites W2805378172 @default.
• W4310995087 cites W2890458481 @default.
• W4310995087 cites W2900343617 @default.
• W4310995087 cites W2903087897 @default.
• W4310995087 cites W2903381708 @default.
• W4310995087 cites W2912289068 @default.
• W4310995087 cites W2973186291 @default.
• W4310995087 cites W2979382042 @default.
• W4310995087 cites W3008591221 @default.
• W4310995087 cites W3024471942 @default.
• W4310995087 cites W3147563004 @default.
• W4310995087 doi "https://doi.org/10.21203/rs.3.rs-2222641/v1" @default.
• W4310995087 hasPublicationYear "2022" @default.
• W4310995087 type Work @default.
• W4310995087 citedByCount "0" @default.
• W4310995087 crossrefType "posted-content" @default.
• W4310995087 hasAuthorship W4310995087A5023492006 @default.
• W4310995087 hasAuthorship W4310995087A5025752244 @default.
• W4310995087 hasAuthorship W4310995087A5031456893 @default.
• W4310995087 hasAuthorship W4310995087A5046140141 @default.
• W4310995087 hasAuthorship W4310995087A5076679983 @default.
• W4310995087 hasBestOaLocation W43109950871 @default.
• W4310995087 hasConcept C104317684 @default.
• W4310995087 hasConcept C118687296 @default.
• W4310995087 hasConcept C138885662 @default.
• W4310995087 hasConcept C143065580 @default.
• W4310995087 hasConcept C179926584 @default.
• W4310995087 hasConcept C185592680 @default.
• W4310995087 hasConcept C203075996 @default.
• W4310995087 hasConcept C22744801 @default.
• W4310995087 hasConcept C2777637488 @default.
• W4310995087 hasConcept C2781427627 @default.
• W4310995087 hasConcept C41895202 @default.
• W4310995087 hasConcept C523546767 @default.
• W4310995087 hasConcept C54355233 @default.
• W4310995087 hasConcept C58123911 @default.
• W4310995087 hasConcept C58207958 @default.
• W4310995087 hasConcept C60987743 @default.
• W4310995087 hasConcept C62130838 @default.
• W4310995087 hasConcept C86803240 @default.
• W4310995087 hasConcept C89423630 @default.
• W4310995087 hasConcept C95444343 @default.
• W4310995087 hasConceptScore W4310995087C104317684 @default.
• W4310995087 hasConceptScore W4310995087C118687296 @default.
• W4310995087 hasConceptScore W4310995087C138885662 @default.
• W4310995087 hasConceptScore W4310995087C143065580 @default.
• W4310995087 hasConceptScore W4310995087C179926584 @default.
• W4310995087 hasConceptScore W4310995087C185592680 @default.
• W4310995087 hasConceptScore W4310995087C203075996 @default.
• W4310995087 hasConceptScore W4310995087C22744801 @default.
• W4310995087 hasConceptScore W4310995087C2777637488 @default.
• W4310995087 hasConceptScore W4310995087C2781427627 @default.
• W4310995087 hasConceptScore W4310995087C41895202 @default.
• W4310995087 hasConceptScore W4310995087C523546767 @default.
• W4310995087 hasConceptScore W4310995087C54355233 @default.
• W4310995087 hasConceptScore W4310995087C58123911 @default.
• W4310995087 hasConceptScore W4310995087C58207958 @default.
• W4310995087 hasConceptScore W4310995087C60987743 @default.
• W4310995087 hasConceptScore W4310995087C62130838 @default.
• W4310995087 hasConceptScore W4310995087C86803240 @default.
• W4310995087 hasConceptScore W4310995087C89423630 @default.
• W4310995087 hasConceptScore W4310995087C95444343 @default.
• W4310995087 hasLocation W43109950871 @default.
• W4310995087 hasOpenAccess W4310995087 @default.
• W4310995087 hasPrimaryLocation W43109950871 @default.

• next