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- W4311002495 abstract "The molecular mechanisms and gene regulatory networks sustaining cell proliferation in neuroblastoma (NBL) cells are still not fully understood. In this tumor context, it has been proposed that anti-proliferative drugs, such as the pan-HDAC inhibitor panobinostat, could be tested to mitigate tumor progression. Here, we set out to investigate the effects of panobinostat treatment at the unprecedented resolution offered by single-cell sequencing. We identified a global senescence signature paired with reduction in proliferation in treated Kelly cells and more isolated transcriptional responses compatible with early neuronal differentiation. Using master regulator analysis, we identified BAZ1A, HCFC1, MAZ, and ZNF146 as the transcriptional regulators most significantly repressed by panobinostat. Experimental silencing of these transcription factors (TFs) confirmed their role in sustaining NBL cell proliferation in vitro." @default.
- W4311002495 created "2022-12-22" @default.
- W4311002495 creator A5031461537 @default.
- W4311002495 creator A5082360687 @default.
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- W4311002495 date "2022-11-29" @default.
- W4311002495 modified "2023-10-06" @default.
- W4311002495 title "Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells" @default.
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- W4311002495 doi "https://doi.org/10.3390/genes13122240" @default.
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