FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311005233> ?p ?o ?g. }

• W4311005233 endingPage "2368" @default.
• W4311005233 startingPage "2368" @default.
• W4311005233 abstract "Colorectal cancer (CRC), associated with an increased intake of processed red meats, saturated fats, and simple carbohydrates accompanied by low dietary fiber, fruits, and vegetables consumption, presents a high epidemiological burden. Connexin43 (Cx43) protein, which forms gap junctions or hemichannels, has tumor suppressor or oncogenic activities in a cancer type- and stage-dependent manner. Cx43 expression varies during colon carcinogenesis, and its functional role is not fully understood. Thus, we evaluated the implications of Cx43 heterologous deletion (Cx43+/−) during the early stages of a chemically induced model of colon carcinogenesis. Female C57BL/6J mice (wild-type or Cx43+/−) were submitted to a colon carcinogenesis model induced by 1,2 dimethylhydrazine (DMH). Mice were euthanized eight hours (week 7) or 30 weeks (week 37) after the last DMH administration to evaluate subacute colon toxicity outcomes or the burden of (pre)neoplastic lesions, respectively. At week 7, Cx43 deficiency inferred no alterations in the DMH-induced increase in systemic (peripheral blood), in situ (colonocytes) DNA damage, and apoptosis in the colonocytes. At week 30, Cx43+/− mice presented an increase in preneoplastic aberrant crypt foci (ACF) multiplicity, while no alterations were observed in colorectal adenoma (CRA) occurrence, multiplicity, volume, proliferation, growth, and β-catenin immunoexpression. Similarly, an in silico analysis of human CRA showed decreased mRNA expression of Cx43 with no correlation with proliferation, apoptosis, and β-catenin markers. These findings indicate the discrete role of Cx43 in the early stages of chemically induced mouse colon carcinogenesis." @default.
• W4311005233 created "2022-12-22" @default.
• W4311005233 creator A5011585293 @default.
• W4311005233 creator A5022699250 @default.
• W4311005233 creator A5032135267 @default.
• W4311005233 creator A5045862213 @default.
• W4311005233 creator A5055360758 @default.
• W4311005233 creator A5067335346 @default.
• W4311005233 date "2022-11-30" @default.
• W4311005233 modified "2023-09-30" @default.
• W4311005233 title "The Implications of Connexin 43 Deficiency during the Early Stages of Chemically Induced Mouse Colon Carcinogenesis" @default.
• W4311005233 cites W1497305870 @default.
• W4311005233 cites W1600329655 @default.
• W4311005233 cites W1873747932 @default.
• W4311005233 cites W1966997112 @default.
• W4311005233 cites W1971995875 @default.
• W4311005233 cites W1972299038 @default.
• W4311005233 cites W1974850478 @default.
• W4311005233 cites W1990387083 @default.
• W4311005233 cites W2001258296 @default.
• W4311005233 cites W2006764235 @default.
• W4311005233 cites W2011705833 @default.
• W4311005233 cites W2019076663 @default.
• W4311005233 cites W2031372290 @default.
• W4311005233 cites W2031777771 @default.
• W4311005233 cites W2031789234 @default.
• W4311005233 cites W2034013480 @default.
• W4311005233 cites W2044387885 @default.
• W4311005233 cites W2046382187 @default.
• W4311005233 cites W2047330711 @default.
• W4311005233 cites W2050124427 @default.
• W4311005233 cites W2057322387 @default.
• W4311005233 cites W2060478844 @default.
• W4311005233 cites W2060693006 @default.
• W4311005233 cites W2061091409 @default.
• W4311005233 cites W2072090020 @default.
• W4311005233 cites W2088479878 @default.
• W4311005233 cites W2088866343 @default.
• W4311005233 cites W2090175366 @default.
• W4311005233 cites W2094994900 @default.
• W4311005233 cites W2096029601 @default.
• W4311005233 cites W2098872610 @default.
• W4311005233 cites W2100124291 @default.
• W4311005233 cites W2110208019 @default.
• W4311005233 cites W2111813832 @default.
• W4311005233 cites W2122982265 @default.
• W4311005233 cites W2133067077 @default.
• W4311005233 cites W2134197481 @default.
• W4311005233 cites W2135348745 @default.
• W4311005233 cites W2141535051 @default.
• W4311005233 cites W2145833401 @default.
• W4311005233 cites W2148500536 @default.
• W4311005233 cites W2152785381 @default.
• W4311005233 cites W2153913069 @default.
• W4311005233 cites W2162569984 @default.
• W4311005233 cites W2168139040 @default.
• W4311005233 cites W2169653318 @default.
• W4311005233 cites W2193493665 @default.
• W4311005233 cites W2266717680 @default.
• W4311005233 cites W2300001177 @default.
• W4311005233 cites W2321876874 @default.
• W4311005233 cites W2396697299 @default.
• W4311005233 cites W2421455087 @default.
• W4311005233 cites W2444433962 @default.
• W4311005233 cites W2463504089 @default.
• W4311005233 cites W2555274871 @default.
• W4311005233 cites W2570044429 @default.
• W4311005233 cites W2607056868 @default.
• W4311005233 cites W2954678774 @default.
• W4311005233 cites W2984360057 @default.
• W4311005233 cites W3009604744 @default.
• W4311005233 cites W3013878851 @default.
• W4311005233 cites W3021495166 @default.
• W4311005233 cites W3038332328 @default.
• W4311005233 cites W3083901997 @default.
• W4311005233 cites W3128646645 @default.
• W4311005233 cites W3155387234 @default.
• W4311005233 cites W3187303247 @default.
• W4311005233 cites W4210261179 @default.
• W4311005233 doi "https://doi.org/10.3390/antiox11122368" @default.
• W4311005233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36552579" @default.
• W4311005233 hasPublicationYear "2022" @default.
• W4311005233 type Work @default.
• W4311005233 citedByCount "0" @default.
• W4311005233 crossrefType "journal-article" @default.
• W4311005233 hasAuthorship W4311005233A5011585293 @default.
• W4311005233 hasAuthorship W4311005233A5022699250 @default.
• W4311005233 hasAuthorship W4311005233A5032135267 @default.
• W4311005233 hasAuthorship W4311005233A5045862213 @default.
• W4311005233 hasAuthorship W4311005233A5055360758 @default.
• W4311005233 hasAuthorship W4311005233A5067335346 @default.
• W4311005233 hasBestOaLocation W43110052331 @default.
• W4311005233 hasConcept C114246631 @default.
• W4311005233 hasConcept C121608353 @default.
• W4311005233 hasConcept C126322002 @default.
• W4311005233 hasConcept C134018914 @default.
• W4311005233 hasConcept C142724271 @default.
• W4311005233 hasConcept C158157758 @default.

• next