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• W4311005693 abstract "Introduction. Irritable bowel syndrome with constipation poses a serious medical and social problem. Studying the pathogenetic mechanisms of irritable bowel syndrome with constipation may improve therapeutic approaches and patient’s quality of life.&#x0D; The aim of this study is to investigate the homocysteine role in the development of abdominal pain syndrome in patients with irritable bowel syndrome and constipation, taking into account body mass index.&#x0D; Subjects and methods. The study involved 55 patients with functional bowel disorders, who were divided into 2 groups: group I (n=27) included patients with functional constipation; II group (n=28) involved patients with irritable bowel syndrome and constipation. The average age of patients in group I was 35.7±8.63 years, in group II – 34.50±9.06 years, the ratio of men and women was 7(25.9%) / 20(74.1%) and 10 (35.7%) / 18(64.28%), respectively. A modified faces pain scale was used to assess pain intensity. Height, weight, and waist circumference were measured, body mass index was calculated according to formula: body mass index = weight (kg)/height (m2). The homocysteine level in the blood serum was measured.&#x0D; Results. Abdominal obesity with the waist circumference greater than 88 cm for women and greater than 102 cm for men was recorded in 6 (21.42%) patients with irritable bowel syndrome and constipation and in 4 (14.81%) patients with functional constipation. The severity of pain and meteorism according to the modified faces scale in patients with irritable bowel syndrome with constipation were respectively 2.4 and 1.7-fold (р˂0.0001) higher than the respective parameters in the patients with functional constipation.&#x0D; The content of homocysteine in the blood serum in the patients with irritable bowel syndrome and constipation was 1.9-fold (р˂0.0001) higher than in the patients with functional constipation. Increased homocysteine level led to the increase in the risk of developing irritable bowel syndrome and constipation (RR=3.61; 95%CI 1.37–9.52; p<0.01). It is important to stress that the serum homocysteine level in the patients with irritable bowel syndrome with constipation was directly correlated with the pain severity assessed by the modified faces pain scale (r=+0.9; p=0.0001).&#x0D; Conclusion. The severity of abdominal pain and meteorism in patients with irritable bowel syndrome and constipation is associated with the homocysteine level in the blood serum." @default.
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• W4311005693 date "2022-11-29" @default.
• W4311005693 modified "2023-10-16" @default.
• W4311005693 title "ROLE OF HOMOCYSTEINE IN DEVELOPMENT OF ABDOMINAL PAIN IN PATIENTS WITH IRRITABLE BOWEL SYNDROME AND CONSTIPATION" @default.
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• W4311005693 doi "https://doi.org/10.31718/2077-1096.22.3.4.75" @default.
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