Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311006191> ?p ?o ?g. }
- W4311006191 endingPage "5881" @default.
- W4311006191 startingPage "5881" @default.
- W4311006191 abstract "High- and low-risk endometrial carcinoma (EC) differ in whether or not a lymphadenectomy is performed. We aimed to develop MRI-based radio-genomic models able to preoperatively assess lymph-vascular space invasion (LVSI) and discriminate between low- and high-risk EC according to the ESMO-ESGO-ESTRO 2020 guidelines, which include molecular risk classification proposed by “ProMisE”. This is a retrospective, multicentric study that included 64 women with EC who underwent 3T-MRI before a hysterectomy. Radiomics features were extracted from T2WI images and apparent diffusion coefficient maps (ADC) after manual segmentation of the gross tumor volume. We constructed a multiple logistic regression approach from the most relevant radiomic features to distinguish between low- and high-risk classes under the ESMO-ESGO-ESTRO 2020 guidelines. A similar approach was taken to assess LVSI. Model diagnostic performance was assessed via ROC curves, accuracy, sensitivity and specificity on training and test sets. The LVSI predictive model used a single feature from ADC as a predictor; the risk class model used two features as predictors from both ADC and T2WI. The low-risk predictive model showed an AUC of 0.74 with an accuracy, sensitivity, and specificity of 0.74, 0.76, 0.94; the LVSI model showed an AUC of 0.59 with an accuracy, sensitivity, and specificity of 0.60, 0.50, 0.61. MRI-based radio-genomic models are useful for preoperative EC risk stratification and may facilitate therapeutic management." @default.
- W4311006191 created "2022-12-22" @default.
- W4311006191 creator A5000872856 @default.
- W4311006191 creator A5002312834 @default.
- W4311006191 creator A5003216983 @default.
- W4311006191 creator A5009404827 @default.
- W4311006191 creator A5014192735 @default.
- W4311006191 creator A5027278814 @default.
- W4311006191 creator A5028807129 @default.
- W4311006191 creator A5041066402 @default.
- W4311006191 creator A5042081469 @default.
- W4311006191 creator A5043660624 @default.
- W4311006191 creator A5047180227 @default.
- W4311006191 creator A5047850842 @default.
- W4311006191 creator A5061006641 @default.
- W4311006191 creator A5064985662 @default.
- W4311006191 creator A5065338930 @default.
- W4311006191 creator A5066560541 @default.
- W4311006191 creator A5066888430 @default.
- W4311006191 creator A5071622125 @default.
- W4311006191 creator A5072059804 @default.
- W4311006191 creator A5072499317 @default.
- W4311006191 creator A5077201041 @default.
- W4311006191 creator A5085902439 @default.
- W4311006191 creator A5086890371 @default.
- W4311006191 creator A5088920406 @default.
- W4311006191 date "2022-11-29" @default.
- W4311006191 modified "2023-10-17" @default.
- W4311006191 title "MRI- and Histologic-Molecular-Based Radio-Genomics Nomogram for Preoperative Assessment of Risk Classes in Endometrial Cancer" @default.
- W4311006191 cites W1565078991 @default.
- W4311006191 cites W2025811877 @default.
- W4311006191 cites W2039203961 @default.
- W4311006191 cites W2059319994 @default.
- W4311006191 cites W2182443159 @default.
- W4311006191 cites W2302249892 @default.
- W4311006191 cites W2303306419 @default.
- W4311006191 cites W2326318458 @default.
- W4311006191 cites W2444196295 @default.
- W4311006191 cites W2515384951 @default.
- W4311006191 cites W2521976517 @default.
- W4311006191 cites W2612695387 @default.
- W4311006191 cites W2786017258 @default.
- W4311006191 cites W2793281906 @default.
- W4311006191 cites W2814443290 @default.
- W4311006191 cites W2887848737 @default.
- W4311006191 cites W2911188335 @default.
- W4311006191 cites W3005252897 @default.
- W4311006191 cites W3013579093 @default.
- W4311006191 cites W3042625737 @default.
- W4311006191 cites W3047272901 @default.
- W4311006191 cites W3083992271 @default.
- W4311006191 cites W3105297947 @default.
- W4311006191 cites W3114074286 @default.
- W4311006191 cites W3128934197 @default.
- W4311006191 cites W3136632344 @default.
- W4311006191 cites W3139236038 @default.
- W4311006191 cites W3168011208 @default.
- W4311006191 cites W3178721497 @default.
- W4311006191 cites W3180826984 @default.
- W4311006191 cites W4210989197 @default.
- W4311006191 doi "https://doi.org/10.3390/cancers14235881" @default.
- W4311006191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36497362" @default.
- W4311006191 hasPublicationYear "2022" @default.
- W4311006191 type Work @default.
- W4311006191 citedByCount "3" @default.
- W4311006191 countsByYear W43110061912023 @default.
- W4311006191 crossrefType "journal-article" @default.
- W4311006191 hasAuthorship W4311006191A5000872856 @default.
- W4311006191 hasAuthorship W4311006191A5002312834 @default.
- W4311006191 hasAuthorship W4311006191A5003216983 @default.
- W4311006191 hasAuthorship W4311006191A5009404827 @default.
- W4311006191 hasAuthorship W4311006191A5014192735 @default.
- W4311006191 hasAuthorship W4311006191A5027278814 @default.
- W4311006191 hasAuthorship W4311006191A5028807129 @default.
- W4311006191 hasAuthorship W4311006191A5041066402 @default.
- W4311006191 hasAuthorship W4311006191A5042081469 @default.
- W4311006191 hasAuthorship W4311006191A5043660624 @default.
- W4311006191 hasAuthorship W4311006191A5047180227 @default.
- W4311006191 hasAuthorship W4311006191A5047850842 @default.
- W4311006191 hasAuthorship W4311006191A5061006641 @default.
- W4311006191 hasAuthorship W4311006191A5064985662 @default.
- W4311006191 hasAuthorship W4311006191A5065338930 @default.
- W4311006191 hasAuthorship W4311006191A5066560541 @default.
- W4311006191 hasAuthorship W4311006191A5066888430 @default.
- W4311006191 hasAuthorship W4311006191A5071622125 @default.
- W4311006191 hasAuthorship W4311006191A5072059804 @default.
- W4311006191 hasAuthorship W4311006191A5072499317 @default.
- W4311006191 hasAuthorship W4311006191A5077201041 @default.
- W4311006191 hasAuthorship W4311006191A5085902439 @default.
- W4311006191 hasAuthorship W4311006191A5086890371 @default.
- W4311006191 hasAuthorship W4311006191A5088920406 @default.
- W4311006191 hasBestOaLocation W43110061911 @default.
- W4311006191 hasConcept C121608353 @default.
- W4311006191 hasConcept C12174686 @default.
- W4311006191 hasConcept C126322002 @default.
- W4311006191 hasConcept C126838900 @default.
- W4311006191 hasConcept C143998085 @default.
- W4311006191 hasConcept C151956035 @default.