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- W4311009872 abstract "Alzheimer’s disease (AD), the foremost variant of dementia, has been associated with a menagerie of risk factors, many of which are considered to be modifiable. Among these modifiable risk factors is circadian rhythm, the chronobiological system that regulates sleep‐wake cycles, food consumption timing, hydration timing, and immune responses amongst many other necessary physiological processes. Circadian rhythm at the level of the suprachiasmatic nucleus (SCN), is tightly regulated in the human body by a host of biomolecular substances, principally the hormones melatonin, cortisol, and serotonin. In addition, photic information projected along afferent pathways to the SCN and peripheral oscillators regulates the synthesis of these hormones and mediates the manner in which they act on the SCN and its substructures. Dysregulation of this cycle, whether induced by environmental changes involving irregular exposure to light, or through endogenous pathology, will have a negative impact on immune system optimization and will heighten the deposition of Aβ and the hyperphosphorylation of the tau protein. Given these correlations, it appears that there is a physiologic association between circadian rhythm dysregulation and AD. This review will explore the physiology of circadian dysregulation in the AD brain, and will propose a basic model for its role in AD‐typical pathology, derived from the literature compiled and referenced throughout." @default.
- W4311009872 created "2022-12-22" @default.
- W4311009872 creator A5074100793 @default.
- W4311009872 date "2022-11-30" @default.
- W4311009872 modified "2023-09-26" @default.
- W4311009872 title "Circadian dysregulation and Alzheimer’s disease: A comprehensive review" @default.
- W4311009872 cites W109228301 @default.
- W4311009872 cites W1502167289 @default.
- W4311009872 cites W1531561323 @default.
- W4311009872 cites W1584834830 @default.
- W4311009872 cites W1593547141 @default.
- W4311009872 cites W1605885548 @default.
- W4311009872 cites W1773909344 @default.
- W4311009872 cites W1798864434 @default.
- W4311009872 cites W1866481691 @default.
- W4311009872 cites W1866757404 @default.
- W4311009872 cites W1958698361 @default.
- W4311009872 cites W1969499415 @default.
- W4311009872 cites W1970199288 @default.
- W4311009872 cites W1973026127 @default.
- W4311009872 cites W1974607744 @default.
- W4311009872 cites W1978065874 @default.
- W4311009872 cites W1980555794 @default.
- W4311009872 cites W1981579010 @default.
- W4311009872 cites W1984652813 @default.
- W4311009872 cites W1985843653 @default.
- W4311009872 cites W1987204546 @default.
- W4311009872 cites W1992830187 @default.
- W4311009872 cites W1997496350 @default.
- W4311009872 cites W1998120137 @default.
- W4311009872 cites W2000693195 @default.
- W4311009872 cites W2001205462 @default.
- W4311009872 cites W2002706824 @default.
- W4311009872 cites W2003916765 @default.
- W4311009872 cites W2009576287 @default.
- W4311009872 cites W2010323016 @default.
- W4311009872 cites W2011624554 @default.
- W4311009872 cites W2013333500 @default.
- W4311009872 cites W2013443406 @default.
- W4311009872 cites W2013537598 @default.
- W4311009872 cites W2015312511 @default.
- W4311009872 cites W2015349939 @default.
- W4311009872 cites W2020624553 @default.
- W4311009872 cites W2024275247 @default.
- W4311009872 cites W2024747286 @default.
- W4311009872 cites W2031353556 @default.
- W4311009872 cites W2031762170 @default.
- W4311009872 cites W2032148429 @default.
- W4311009872 cites W2036790426 @default.
- W4311009872 cites W2037138827 @default.
- W4311009872 cites W2040145088 @default.
- W4311009872 cites W2042140148 @default.
- W4311009872 cites W2042539885 @default.
- W4311009872 cites W2044987522 @default.
- W4311009872 cites W2049613345 @default.
- W4311009872 cites W2049842274 @default.
- W4311009872 cites W2053696585 @default.
- W4311009872 cites W2055533354 @default.
- W4311009872 cites W2057692665 @default.
- W4311009872 cites W2060851420 @default.
- W4311009872 cites W2062636872 @default.
- W4311009872 cites W2063313379 @default.
- W4311009872 cites W2065225923 @default.
- W4311009872 cites W2068800193 @default.
- W4311009872 cites W2070497729 @default.
- W4311009872 cites W2071232202 @default.
- W4311009872 cites W2074589301 @default.
- W4311009872 cites W2076143792 @default.
- W4311009872 cites W2078145300 @default.
- W4311009872 cites W2079007392 @default.
- W4311009872 cites W2081670043 @default.
- W4311009872 cites W2085843620 @default.
- W4311009872 cites W2086520973 @default.
- W4311009872 cites W2086667809 @default.
- W4311009872 cites W2087243986 @default.
- W4311009872 cites W2093783796 @default.
- W4311009872 cites W2094426488 @default.
- W4311009872 cites W2096367894 @default.
- W4311009872 cites W2096963202 @default.
- W4311009872 cites W2097162146 @default.
- W4311009872 cites W2098697701 @default.
- W4311009872 cites W2100610042 @default.
- W4311009872 cites W2102656701 @default.
- W4311009872 cites W2104247936 @default.
- W4311009872 cites W2104399350 @default.
- W4311009872 cites W2106497761 @default.
- W4311009872 cites W2107018300 @default.
- W4311009872 cites W2108130957 @default.
- W4311009872 cites W2109528022 @default.
- W4311009872 cites W2114688004 @default.
- W4311009872 cites W2114728551 @default.
- W4311009872 cites W2116205810 @default.
- W4311009872 cites W2117286783 @default.
- W4311009872 cites W2117503265 @default.
- W4311009872 cites W2118642813 @default.
- W4311009872 cites W211905087 @default.
- W4311009872 cites W2120290894 @default.
- W4311009872 cites W2120317655 @default.