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• W4311014193 endingPage "742" @default.
• W4311014193 startingPage "742" @default.
• W4311014193 abstract "The hyaluronic acid (HA) hydrogel array was employed for immobilization of 5-fluorouracil (5-FU), and the electrospun bilayer (hydrophilic: polyurethane/pluronic F-127 and hydrophobic: polyurethane) membrane was used to support the HA hydrogel array as a patch. To visualize the drug propagating phenomenon into tissues, we experimentally investigated how FITC-BSA diffused into the tissue by applying hydrogel patches to porcine tissue samples. The diffusive phenomenon basically depends on the FITC-BSA diffusion coefficient in the hydrogel, and the degree of diffusion of FITC-BSA may be affected by the concentration of HA hydrogel, which demonstrates that the high density of HA hydrogel inhibits the diffusive FITC-BSA migration toward the low concentration region. YD-10B cells were employed to investigate the release of 5-FU from the HA array on the bilayer membrane. In the control group, YD-10B cell viability was over 98% after 3 days. However, in the 5-FU-immobilized HA hydrogel array, most of the YD-10B cells were not attached to the bilayer membrane used as a scaffold. These results suggest that 5-FU was locally released and initiated the death of the YD-10B cells. Our results show that 5-FU immobilized on HA arrays significantly reduces YD-10B cell adhesion and proliferation, affecting cells even early in the cell culture. Our results suggest that when 5-FU is immobilized in the HA hydrogel array on the bilayer membrane as a drug patch, it is possible to control the drug concentration, to release it continuously, and that the patch can be applied locally to the targeted tumor site and administer the drug in a time-stable manner. Therefore, the developed bilayer membrane-based HA hydrogel array patch can be considered for sustained release of the drug in biomedical applications." @default.
• W4311014193 created "2022-12-22" @default.
• W4311014193 creator A5021528859 @default.
• W4311014193 creator A5024193161 @default.
• W4311014193 creator A5085379167 @default.
• W4311014193 creator A5085911620 @default.
• W4311014193 date "2022-11-30" @default.
• W4311014193 modified "2023-10-05" @default.
• W4311014193 title "5-Fluorouracil-Immobilized Hyaluronic Acid Hydrogel Arrays on an Electrospun Bilayer Membrane as a Drug Patch" @default.
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• W4311014193 doi "https://doi.org/10.3390/bioengineering9120742" @default.
• W4311014193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36550948" @default.
• W4311014193 hasPublicationYear "2022" @default.
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• W4311014193 hasAuthorship W4311014193A5085379167 @default.

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