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• W4311018498 endingPage "1376" @default.
• W4311018498 startingPage "1362" @default.
• W4311018498 abstract "Radioisotopes of Cu, such as 64Cu and 67Cu, are alluring targets for imaging (e.g., positron emission tomography, PET) and radiotherapeutic applications. Cyclen-based macrocyclic polyaminocarboxylates are one of the most frequently examined bifunctional chelators in vitro and in vivo, including the FDA-approved 64Cu radiopharmaceutical, Cu(DOTATATE) (Detectnet); however, connections between the structure of plausible reactive intermediates and their stability under physiologically relevant conditions remain to be established. In this study, we share the synthesis of a cyclen-based, N,N-alkylated spirocyclic chelate, H2DO3AC4H8, which serves as a model for N-protonation. Our combined experimental (in vitro and in vivo) and computational studies unravel complex pH-dependent speciation and enable side-by-side comparison of N- and O-protonated species of relevant 64Cu radiopharmaceuticals. Our studies suggest that N-protonated species are not inherently unstable species under physiological conditions and demonstrate the potential of N,N-alkylation as a tool for the rational design of future radiopharmaceuticals." @default.
• W4311018498 created "2022-12-22" @default.
• W4311018498 creator A5002619922 @default.
• W4311018498 creator A5023826838 @default.
• W4311018498 creator A5025391926 @default.
• W4311018498 creator A5029040743 @default.
• W4311018498 creator A5034572748 @default.
• W4311018498 creator A5039731412 @default.
• W4311018498 creator A5052255441 @default.
• W4311018498 creator A5056110227 @default.
• W4311018498 creator A5060956899 @default.
• W4311018498 date "2022-12-09" @default.
• W4311018498 modified "2023-09-26" @default.
• W4311018498 title "<i>N</i>,<i>N</i>-Alkylation Clarifies the Role of <i>N</i>- and <i>O</i>-Protonated Intermediates in Cyclen-Based ⁶⁴Cu Radiopharmaceuticals" @default.
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