FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311018574> ?p ?o ?g. }

• W4311018574 endingPage "122" @default.
• W4311018574 startingPage "105" @default.
• W4311018574 abstract "Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, and aneugenicity) have been limited to dichotomous hazard classification, while other toxicity endpoints are assessed through quantitative determination of points-of-departures (PODs) for setting exposure limits. The more recent higher-throughput in vitro genotoxicity assays, many of which also provide mechanistic information, offer a powerful approach for determining defined PODs for potency ranking and risk assessment. In order to obtain relevant human dose context from the in vitro assays, in vitro to in vivo extrapolation (IVIVE) models are required to determine what dose would elicit a concentration in the body demonstrated to be genotoxic using in vitro assays. Previous work has demonstrated that application of IVIVE models to in vitro bioactivity data can provide PODs that are protective of human health, but there has been no evaluation of how these models perform with in vitro genotoxicity data. Thus, the Genetic Toxicology Technical Committee, under the Health and Environmental Sciences Institute, conducted a case study on 31 reference chemicals to evaluate the performance of IVIVE application to genotoxicity data. The results demonstrate that for most chemicals considered here (20/31), the PODs derived from in vitro data and IVIVE are health protective relative to in vivo PODs from animal studies. PODs were also protective by assay target: mutations (8/13 chemicals), micronuclei (9/12), and aneugenicity markers (4/4). It is envisioned that this novel testing strategy could enhance prioritization, rapid screening, and risk assessment of genotoxic chemicals." @default.
• W4311018574 created "2022-12-22" @default.
• W4311018574 creator A5000691101 @default.
• W4311018574 creator A5005887349 @default.
• W4311018574 creator A5006742120 @default.
• W4311018574 creator A5011331685 @default.
• W4311018574 creator A5016694223 @default.
• W4311018574 creator A5020495575 @default.
• W4311018574 creator A5021264532 @default.
• W4311018574 creator A5021440089 @default.
• W4311018574 creator A5021821151 @default.
• W4311018574 creator A5025279502 @default.
• W4311018574 creator A5030420930 @default.
• W4311018574 creator A5053423213 @default.
• W4311018574 creator A5071532662 @default.
• W4311018574 creator A5071573675 @default.
• W4311018574 creator A5074155434 @default.
• W4311018574 creator A5078015162 @default.
• W4311018574 creator A5089948375 @default.
• W4311018574 creator A5091403004 @default.
• W4311018574 date "2022-12-22" @default.
• W4311018574 modified "2023-10-01" @default.
• W4311018574 title "Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose" @default.
• W4311018574 cites W1879339955 @default.
• W4311018574 cites W1910074863 @default.
• W4311018574 cites W1919456477 @default.
• W4311018574 cites W1968482893 @default.
• W4311018574 cites W2009077052 @default.
• W4311018574 cites W2044809478 @default.
• W4311018574 cites W2045345325 @default.
• W4311018574 cites W2053964066 @default.
• W4311018574 cites W2061226942 @default.
• W4311018574 cites W2087431074 @default.
• W4311018574 cites W2096127677 @default.
• W4311018574 cites W2112072201 @default.
• W4311018574 cites W2131056563 @default.
• W4311018574 cites W2140927372 @default.
• W4311018574 cites W2147334256 @default.
• W4311018574 cites W2147452172 @default.
• W4311018574 cites W2166924376 @default.
• W4311018574 cites W2178342419 @default.
• W4311018574 cites W2186188114 @default.
• W4311018574 cites W2235722834 @default.
• W4311018574 cites W2314745102 @default.
• W4311018574 cites W2555699155 @default.
• W4311018574 cites W2558649973 @default.
• W4311018574 cites W2600915513 @default.
• W4311018574 cites W2618144102 @default.
• W4311018574 cites W2734700870 @default.
• W4311018574 cites W2749830926 @default.
• W4311018574 cites W2766622790 @default.
• W4311018574 cites W2769853272 @default.
• W4311018574 cites W2791653123 @default.
• W4311018574 cites W2794565592 @default.
• W4311018574 cites W2885479476 @default.
• W4311018574 cites W2891195631 @default.
• W4311018574 cites W2902613916 @default.
• W4311018574 cites W2904696250 @default.
• W4311018574 cites W2912965338 @default.
• W4311018574 cites W2935834115 @default.
• W4311018574 cites W2945365879 @default.
• W4311018574 cites W2973521279 @default.
• W4311018574 cites W2973820246 @default.
• W4311018574 cites W2994223600 @default.
• W4311018574 cites W3107909124 @default.
• W4311018574 cites W3165548978 @default.
• W4311018574 cites W3169532429 @default.
• W4311018574 cites W4224225277 @default.
• W4311018574 cites W4229036058 @default.
• W4311018574 cites W4252625309 @default.
• W4311018574 cites W4296060396 @default.
• W4311018574 cites W4308554868 @default.
• W4311018574 doi "https://doi.org/10.1002/em.22521" @default.
• W4311018574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36495195" @default.
• W4311018574 hasPublicationYear "2022" @default.
• W4311018574 type Work @default.
• W4311018574 citedByCount "2" @default.
• W4311018574 countsByYear W43110185742023 @default.
• W4311018574 crossrefType "journal-article" @default.
• W4311018574 hasAuthorship W4311018574A5000691101 @default.
• W4311018574 hasAuthorship W4311018574A5005887349 @default.
• W4311018574 hasAuthorship W4311018574A5006742120 @default.
• W4311018574 hasAuthorship W4311018574A5011331685 @default.
• W4311018574 hasAuthorship W4311018574A5016694223 @default.
• W4311018574 hasAuthorship W4311018574A5020495575 @default.
• W4311018574 hasAuthorship W4311018574A5021264532 @default.
• W4311018574 hasAuthorship W4311018574A5021440089 @default.
• W4311018574 hasAuthorship W4311018574A5021821151 @default.
• W4311018574 hasAuthorship W4311018574A5025279502 @default.
• W4311018574 hasAuthorship W4311018574A5030420930 @default.
• W4311018574 hasAuthorship W4311018574A5053423213 @default.
• W4311018574 hasAuthorship W4311018574A5071532662 @default.
• W4311018574 hasAuthorship W4311018574A5071573675 @default.
• W4311018574 hasAuthorship W4311018574A5074155434 @default.
• W4311018574 hasAuthorship W4311018574A5078015162 @default.
• W4311018574 hasAuthorship W4311018574A5089948375 @default.
• W4311018574 hasAuthorship W4311018574A5091403004 @default.
• W4311018574 hasBestOaLocation W43110185741 @default.

• next