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• W4311018601 abstract "Oxytocin (OT) has a well-established role in reproductive behaviours; however, it recently emerged as an important regulator of energy homeostasis. In addition to central nervous system (CNS), OT is found in the plasma and OT receptors (OT-R) are found in peripheral tissues relevant to energy balance regulation. Here, we aim to determine whether peripheral OT-R activation is sufficient to alter energy intake and expenditure.We first show that systemic OT potently reduced food intake and food-motivated behaviour for a high-fat reward in male and female rats. As it is plausible that peripherally, intraperitoneally (IP) injected OT crosses the blood-brain barrier (BBB) to produce some of the metabolic effects within the CNS, we screened, with a novel fluorescently labelled-OT (fAF546-OT, Roxy), for the presence of IP-injected Roxy in CNS tissue relevant to feeding control and compared such with BBB-impermeable fluorescent OT-B12 (fCy5-OT-B12; BRoxy). While Roxy did penetrate the CNS, BRoxy did not. To evaluate the behavioural and thermoregulatory impact of exclusive activation of peripheral OT-R, we generated a novel BBB-impermeable OT (OT-B12 ), with equipotent binding at OT-R in vitro. In vivo, IP-injected OT and OT-B12 were equipotent at food intake suppression in rats of both sexes, suggesting that peripheral OT acts on peripheral OT-R to reduce feeding behaviour. Importantly, OT induced a potent conditioned taste avoidance, indistinguishable from that induced by LiCl, when applied peripherally. Remarkably, and in contrast to OT, OT-B12 did not induce any conditioned taste avoidance. Limiting the CNS entry of OT also resulted in a dose-dependent reduction of emesis in male shrews. While both OT and OT-B12 proved to have similar effects on body temperature, only OT resulted in home-cage locomotor depression.Together our data indicate that limiting systemic OT CNS penetrance preserves the anorexic effects of the peptide and reduces the clinically undesired side effects of OT: emesis, taste avoidance and locomotor depression. Thus, therapeutic targeting of peripheral OT-R may be a viable strategy to achieve appetite suppression with better patient outcomes." @default.
• W4311018601 created "2022-12-22" @default.
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• W4311018601 creator A5079833063 @default.
• W4311018601 date "2023-01-09" @default.
• W4311018601 modified "2023-10-10" @default.
• W4311018601 title "Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while <scp>CNS</scp> entry is required for locomotor and taste avoidance effects" @default.
• W4311018601 cites W1532235063 @default.
• W4311018601 cites W1592574065 @default.
• W4311018601 cites W1636089071 @default.
• W4311018601 cites W1856552928 @default.
• W4311018601 cites W1933134317 @default.
• W4311018601 cites W1967332436 @default.
• W4311018601 cites W1968246625 @default.
• W4311018601 cites W1970250630 @default.
• W4311018601 cites W1972127276 @default.
• W4311018601 cites W1998893802 @default.
• W4311018601 cites W2000988746 @default.
• W4311018601 cites W2001160654 @default.
• W4311018601 cites W2002694341 @default.
• W4311018601 cites W2005380415 @default.
• W4311018601 cites W2006179817 @default.
• W4311018601 cites W2006856734 @default.
• W4311018601 cites W2009542179 @default.
• W4311018601 cites W2015172493 @default.
• W4311018601 cites W2016886211 @default.
• W4311018601 cites W2017262236 @default.
• W4311018601 cites W2027489786 @default.
• W4311018601 cites W2035236814 @default.
• W4311018601 cites W2035269878 @default.
• W4311018601 cites W2039000755 @default.
• W4311018601 cites W2045447297 @default.
• W4311018601 cites W2057424192 @default.
• W4311018601 cites W2063397475 @default.
• W4311018601 cites W2068155003 @default.
• W4311018601 cites W2070532232 @default.
• W4311018601 cites W2073559421 @default.
• W4311018601 cites W2077496630 @default.
• W4311018601 cites W2084234221 @default.
• W4311018601 cites W2089802798 @default.
• W4311018601 cites W2094704091 @default.
• W4311018601 cites W2100997766 @default.
• W4311018601 cites W2103859861 @default.
• W4311018601 cites W2105153328 @default.
• W4311018601 cites W2106066602 @default.
• W4311018601 cites W2125369584 @default.
• W4311018601 cites W2128060088 @default.
• W4311018601 cites W2130461169 @default.
• W4311018601 cites W2132011251 @default.
• W4311018601 cites W2149050611 @default.
• W4311018601 cites W2150655622 @default.
• W4311018601 cites W2154655754 @default.
• W4311018601 cites W2164232724 @default.
• W4311018601 cites W2170598916 @default.
• W4311018601 cites W2194605942 @default.
• W4311018601 cites W2206575616 @default.
• W4311018601 cites W2211725812 @default.
• W4311018601 cites W2214360346 @default.
• W4311018601 cites W2283149320 @default.
• W4311018601 cites W2291910588 @default.
• W4311018601 cites W2309273322 @default.
• W4311018601 cites W2400287868 @default.
• W4311018601 cites W2415516117 @default.
• W4311018601 cites W2517236389 @default.
• W4311018601 cites W2552269395 @default.
• W4311018601 cites W2557831994 @default.
• W4311018601 cites W2577769035 @default.
• W4311018601 cites W2588711109 @default.
• W4311018601 cites W2625146988 @default.
• W4311018601 cites W2733991598 @default.
• W4311018601 cites W2735102984 @default.
• W4311018601 cites W2737278723 @default.
• W4311018601 cites W2738723337 @default.
• W4311018601 cites W2751161060 @default.
• W4311018601 cites W2755719114 @default.
• W4311018601 cites W2781710096 @default.
• W4311018601 cites W2782759123 @default.
• W4311018601 cites W2794182166 @default.
• W4311018601 cites W2885908014 @default.
• W4311018601 cites W2887043598 @default.
• W4311018601 cites W2888120688 @default.
• W4311018601 cites W2888739644 @default.
• W4311018601 cites W2909847070 @default.
• W4311018601 cites W2937697660 @default.
• W4311018601 cites W2974117004 @default.

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