FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311027674> ?p ?o ?g. }

• W4311027674 endingPage "131" @default.
• W4311027674 startingPage "122" @default.
• W4311027674 abstract "This open-label, randomized, 3-treatment, 3-period, 6-sequence, crossover study in healthy subjects compared the pharmacokinetic and pharmacodynamic properties of a lipid-based (soft gelatin capsule) prototype final market image (pFMI) formulation of tropifexor (90-µg) to its clinical service form (CSF) and assessed the food effect for the pFMI formulation. In the fasted state, drug exposure was higher for the pFMI. The geometric mean ratios for pFMI versus CSF of peak concentration and area under the concentration-time curve were 2.0 and 1.5, respectively. No food effect was apparent for the pFMI formulation, and the geometric mean ratios for pFMI fed versus pFMI fasted of peak concentration and area under concentration-time curve were 1.0 and 1.0 respectively. Despite having lower systemic exposure, the CSF formulation provided a higher pharmacological response for the gut biomarker fibroblast growth factor 19. Under fasted conditions, fibroblast growth factor 19 maximum change from baseline serum concentration after drug administration and area under the change from baseline serum concentration-time curve from time 0 to 24 hours were 36% for CSF and 12% for FMI. For a second biomarker, serum 7-alpha hydroxy-4-cholest-3-one, the pharmacological activity was comparable between CSF (fasted) and pFMI (both fasted and fed states). The pFMI offers advantages over the CSF in terms of insensitivity to food effect, lower intersubject variability, and overcoming solubility limitations." @default.
• W4311027674 created "2022-12-22" @default.
• W4311027674 creator A5000594102 @default.
• W4311027674 creator A5005604593 @default.
• W4311027674 creator A5022472681 @default.
• W4311027674 creator A5048817987 @default.
• W4311027674 creator A5064974711 @default.
• W4311027674 creator A5078607812 @default.
• W4311027674 creator A5081030176 @default.
• W4311027674 creator A5087333350 @default.
• W4311027674 date "2022-12-10" @default.
• W4311027674 modified "2023-10-02" @default.
• W4311027674 title "A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants" @default.
• W4311027674 cites W1886088333 @default.
• W4311027674 cites W1954050093 @default.
• W4311027674 cites W1963587340 @default.
• W4311027674 cites W1966514588 @default.
• W4311027674 cites W1970740746 @default.
• W4311027674 cites W1985210677 @default.
• W4311027674 cites W1989357395 @default.
• W4311027674 cites W1997106286 @default.
• W4311027674 cites W2005911243 @default.
• W4311027674 cites W2015767901 @default.
• W4311027674 cites W2022279737 @default.
• W4311027674 cites W2061742628 @default.
• W4311027674 cites W2079261283 @default.
• W4311027674 cites W2087577664 @default.
• W4311027674 cites W2106768039 @default.
• W4311027674 cites W2334452059 @default.
• W4311027674 cites W2519114186 @default.
• W4311027674 cites W2612631436 @default.
• W4311027674 cites W2769380893 @default.
• W4311027674 cites W2784137104 @default.
• W4311027674 cites W2883359071 @default.
• W4311027674 cites W2946054531 @default.
• W4311027674 cites W2994629683 @default.
• W4311027674 cites W3045187805 @default.
• W4311027674 cites W3157794914 @default.
• W4311027674 cites W3208364643 @default.
• W4311027674 doi "https://doi.org/10.1002/cpdd.1208" @default.
• W4311027674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36495282" @default.
• W4311027674 hasPublicationYear "2022" @default.
• W4311027674 type Work @default.
• W4311027674 citedByCount "0" @default.
• W4311027674 crossrefType "journal-article" @default.
• W4311027674 hasAuthorship W4311027674A5000594102 @default.
• W4311027674 hasAuthorship W4311027674A5005604593 @default.
• W4311027674 hasAuthorship W4311027674A5022472681 @default.
• W4311027674 hasAuthorship W4311027674A5048817987 @default.
• W4311027674 hasAuthorship W4311027674A5064974711 @default.
• W4311027674 hasAuthorship W4311027674A5078607812 @default.
• W4311027674 hasAuthorship W4311027674A5081030176 @default.
• W4311027674 hasAuthorship W4311027674A5087333350 @default.
• W4311027674 hasConcept C105795698 @default.
• W4311027674 hasConcept C111113717 @default.
• W4311027674 hasConcept C112705442 @default.
• W4311027674 hasConcept C126322002 @default.
• W4311027674 hasConcept C134018914 @default.
• W4311027674 hasConcept C142724271 @default.
• W4311027674 hasConcept C170493617 @default.
• W4311027674 hasConcept C181389837 @default.
• W4311027674 hasConcept C185592680 @default.
• W4311027674 hasConcept C204787440 @default.
• W4311027674 hasConcept C27081682 @default.
• W4311027674 hasConcept C2778938600 @default.
• W4311027674 hasConcept C2781197716 @default.
• W4311027674 hasConcept C33923547 @default.
• W4311027674 hasConcept C40222840 @default.
• W4311027674 hasConcept C55493867 @default.
• W4311027674 hasConcept C71924100 @default.
• W4311027674 hasConcept C76318530 @default.
• W4311027674 hasConcept C87813604 @default.
• W4311027674 hasConcept C98274493 @default.
• W4311027674 hasConceptScore W4311027674C105795698 @default.
• W4311027674 hasConceptScore W4311027674C111113717 @default.
• W4311027674 hasConceptScore W4311027674C112705442 @default.
• W4311027674 hasConceptScore W4311027674C126322002 @default.
• W4311027674 hasConceptScore W4311027674C134018914 @default.
• W4311027674 hasConceptScore W4311027674C142724271 @default.
• W4311027674 hasConceptScore W4311027674C170493617 @default.
• W4311027674 hasConceptScore W4311027674C181389837 @default.
• W4311027674 hasConceptScore W4311027674C185592680 @default.
• W4311027674 hasConceptScore W4311027674C204787440 @default.
• W4311027674 hasConceptScore W4311027674C27081682 @default.
• W4311027674 hasConceptScore W4311027674C2778938600 @default.
• W4311027674 hasConceptScore W4311027674C2781197716 @default.
• W4311027674 hasConceptScore W4311027674C33923547 @default.
• W4311027674 hasConceptScore W4311027674C40222840 @default.
• W4311027674 hasConceptScore W4311027674C55493867 @default.
• W4311027674 hasConceptScore W4311027674C71924100 @default.
• W4311027674 hasConceptScore W4311027674C76318530 @default.
• W4311027674 hasConceptScore W4311027674C87813604 @default.
• W4311027674 hasConceptScore W4311027674C98274493 @default.
• W4311027674 hasIssue "2" @default.
• W4311027674 hasLocation W43110276741 @default.
• W4311027674 hasLocation W43110276742 @default.
• W4311027674 hasOpenAccess W4311027674 @default.
• W4311027674 hasPrimaryLocation W43110276741 @default.

• next