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• W4311027844 startingPage "113549" @default.
• W4311027844 abstract "Aspartame has been studied extensively and evaluated for its safety in foods and beverages yet concerns for its potential carcinogenicity have persisted, driven primarily by animal studies conducted at the Ramazzini Institute (RI). To address this controversy, an updated systematic review of available human, animal, and mechanistic data was conducted leveraging critical assessment tools to consider the quality and reliability of data. The evidence base includes 12 animal studies and >40 epidemiological studies reviewed by the World Health Organization which collectively demonstrate a lack of carcinogenic effect. Assessment of >1360 mechanistic endpoints, including many guideline-based genotoxicity studies, demonstrate a lack of activity associated with endpoints grouped to key characteristics of carcinogens. Other non-specific mechanistic data (e.g., mixed findings of oxidative stress across study models, tissues, and species) do not provide evidence of a biologically plausible carcinogenic pathway associated with aspartame. Taken together, available evidence supports that aspartame consumption is not carcinogenic in humans and that the inconsistent findings of the RI studies may be explained by flaws in study design and conduct (despite additional analyses to address study limitations), as acknowledged by authoritative bodies." @default.
• W4311027844 created "2022-12-22" @default.
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• W4311027844 date "2023-02-01" @default.
• W4311027844 modified "2023-10-13" @default.
• W4311027844 title "Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame" @default.
• W4311027844 cites W1148896616 @default.
• W4311027844 cites W1158426662 @default.
• W4311027844 cites W1879098942 @default.
• W4311027844 cites W1915513917 @default.
• W4311027844 cites W1967641499 @default.
• W4311027844 cites W1974068770 @default.
• W4311027844 cites W1977826880 @default.
• W4311027844 cites W1982561147 @default.
• W4311027844 cites W1983746434 @default.
• W4311027844 cites W1987054374 @default.
• W4311027844 cites W1988034760 @default.
• W4311027844 cites W2003379970 @default.
• W4311027844 cites W2004661554 @default.
• W4311027844 cites W2008187432 @default.
• W4311027844 cites W2010129246 @default.
• W4311027844 cites W2011614389 @default.
• W4311027844 cites W2014720929 @default.
• W4311027844 cites W2016092552 @default.
• W4311027844 cites W2016584683 @default.
• W4311027844 cites W2017146849 @default.
• W4311027844 cites W2022887220 @default.
• W4311027844 cites W2026360434 @default.
• W4311027844 cites W2027808454 @default.
• W4311027844 cites W2028348553 @default.
• W4311027844 cites W2029755975 @default.
• W4311027844 cites W2032640252 @default.
• W4311027844 cites W2032751799 @default.
• W4311027844 cites W2044091148 @default.
• W4311027844 cites W2052645136 @default.
• W4311027844 cites W2052738915 @default.
• W4311027844 cites W2057712379 @default.
• W4311027844 cites W2060624355 @default.
• W4311027844 cites W2065385074 @default.
• W4311027844 cites W2079685994 @default.
• W4311027844 cites W2079712252 @default.
• W4311027844 cites W2081084805 @default.
• W4311027844 cites W2089131685 @default.
• W4311027844 cites W2097480836 @default.
• W4311027844 cites W2099019193 @default.
• W4311027844 cites W2119924327 @default.
• W4311027844 cites W2120450196 @default.
• W4311027844 cites W2123880692 @default.
• W4311027844 cites W2124072109 @default.
• W4311027844 cites W2124974886 @default.
• W4311027844 cites W2127871853 @default.
• W4311027844 cites W2130284699 @default.
• W4311027844 cites W2145834137 @default.
• W4311027844 cites W2153526310 @default.
• W4311027844 cites W2158241708 @default.
• W4311027844 cites W2173513074 @default.
• W4311027844 cites W2275998336 @default.
• W4311027844 cites W2397394044 @default.
• W4311027844 cites W2510456830 @default.
• W4311027844 cites W2544544538 @default.
• W4311027844 cites W2563475795 @default.
• W4311027844 cites W2564063689 @default.
• W4311027844 cites W2564203143 @default.
• W4311027844 cites W2585751575 @default.
• W4311027844 cites W2587505874 @default.
• W4311027844 cites W2588170688 @default.
• W4311027844 cites W2591577933 @default.
• W4311027844 cites W2592470974 @default.
• W4311027844 cites W2607200743 @default.
• W4311027844 cites W2611174186 @default.
• W4311027844 cites W2612847450 @default.
• W4311027844 cites W2731936918 @default.
• W4311027844 cites W2752311095 @default.
• W4311027844 cites W2752922426 @default.
• W4311027844 cites W2753563259 @default.
• W4311027844 cites W2754430307 @default.
• W4311027844 cites W2765212011 @default.
• W4311027844 cites W2775754174 @default.
• W4311027844 cites W2784325197 @default.
• W4311027844 cites W2788203274 @default.
• W4311027844 cites W2789988379 @default.
• W4311027844 cites W2790301404 @default.
• W4311027844 cites W2791244870 @default.
• W4311027844 cites W2800299324 @default.
• W4311027844 cites W2805423095 @default.
• W4311027844 cites W2897285370 @default.
• W4311027844 cites W2900129601 @default.
• W4311027844 cites W2901705744 @default.
• W4311027844 cites W2905010559 @default.

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