Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311039978> ?p ?o ?g. }
- W4311039978 endingPage "15021" @default.
- W4311039978 startingPage "15021" @default.
- W4311039978 abstract "Protein secretion plays a central role in modulating interactions of the human pathogen Listeria monocytogenes with its environment. Recently, secretion of RNA has emerged as an important strategy used by the pathogen to manipulate the host cell response to its advantage. In general, the Sec-dependent translocation pathway is a major route for protein secretion in L. monocytogenes, but mechanistic insights into the secretion of RNA by these pathways are lacking. Apart from the classical SecA1 secretion pathway, L. monocytogenes also encodes for a SecA paralogue (SecA2) which targets the export of a specific subset of proteins, some of which are involved in virulence. Here, we demonstrated that SecA2 co-sediments with translating ribosomes and provided evidence that it associates with a subset of secreted small non-coding RNAs (sRNAs) that induce high levels of IFN-β response in host cells. We found that enolase, which is translocated by a SecA2-dependent mechanism, binds to several sRNAs, suggesting a pathway by which sRNAs are targeted to the supernatant of L. monocytogenes." @default.
- W4311039978 created "2022-12-22" @default.
- W4311039978 creator A5008015414 @default.
- W4311039978 creator A5014525990 @default.
- W4311039978 creator A5026583601 @default.
- W4311039978 creator A5028420889 @default.
- W4311039978 creator A5040042590 @default.
- W4311039978 creator A5057272765 @default.
- W4311039978 creator A5061655044 @default.
- W4311039978 creator A5071269452 @default.
- W4311039978 creator A5076431272 @default.
- W4311039978 creator A5077494803 @default.
- W4311039978 date "2022-11-30" @default.
- W4311039978 modified "2023-10-01" @default.
- W4311039978 title "SecA2 Associates with Translating Ribosomes and Contributes to the Secretion of Potent IFN-β Inducing RNAs" @default.
- W4311039978 cites W1534754726 @default.
- W4311039978 cites W1559269196 @default.
- W4311039978 cites W1821737407 @default.
- W4311039978 cites W1847932158 @default.
- W4311039978 cites W1861769482 @default.
- W4311039978 cites W1887891256 @default.
- W4311039978 cites W1899820272 @default.
- W4311039978 cites W1907239588 @default.
- W4311039978 cites W1941479381 @default.
- W4311039978 cites W1965892962 @default.
- W4311039978 cites W1977949781 @default.
- W4311039978 cites W1993356535 @default.
- W4311039978 cites W1995517639 @default.
- W4311039978 cites W1996093408 @default.
- W4311039978 cites W2005518105 @default.
- W4311039978 cites W2006542568 @default.
- W4311039978 cites W2014119909 @default.
- W4311039978 cites W2027237297 @default.
- W4311039978 cites W2028823305 @default.
- W4311039978 cites W2035295085 @default.
- W4311039978 cites W2048528832 @default.
- W4311039978 cites W2054962153 @default.
- W4311039978 cites W2066510985 @default.
- W4311039978 cites W2066886643 @default.
- W4311039978 cites W2067779211 @default.
- W4311039978 cites W2071212473 @default.
- W4311039978 cites W2078739770 @default.
- W4311039978 cites W2083116560 @default.
- W4311039978 cites W2090591880 @default.
- W4311039978 cites W2092426058 @default.
- W4311039978 cites W2094692479 @default.
- W4311039978 cites W2096819418 @default.
- W4311039978 cites W2098624337 @default.
- W4311039978 cites W2110864354 @default.
- W4311039978 cites W2113757071 @default.
- W4311039978 cites W2115138998 @default.
- W4311039978 cites W2117414599 @default.
- W4311039978 cites W2119833280 @default.
- W4311039978 cites W2124081897 @default.
- W4311039978 cites W2128169214 @default.
- W4311039978 cites W2130743035 @default.
- W4311039978 cites W2133567480 @default.
- W4311039978 cites W2133790733 @default.
- W4311039978 cites W2133884021 @default.
- W4311039978 cites W2148490163 @default.
- W4311039978 cites W2161435619 @default.
- W4311039978 cites W2167198550 @default.
- W4311039978 cites W2167703516 @default.
- W4311039978 cites W2321423077 @default.
- W4311039978 cites W2516449150 @default.
- W4311039978 cites W2533929233 @default.
- W4311039978 cites W2559151234 @default.
- W4311039978 cites W2794832038 @default.
- W4311039978 cites W2804590941 @default.
- W4311039978 cites W2896695296 @default.
- W4311039978 cites W2979486590 @default.
- W4311039978 cites W2991013360 @default.
- W4311039978 cites W3203631026 @default.
- W4311039978 doi "https://doi.org/10.3390/ijms232315021" @default.
- W4311039978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36499346" @default.
- W4311039978 hasPublicationYear "2022" @default.
- W4311039978 type Work @default.
- W4311039978 citedByCount "1" @default.
- W4311039978 countsByYear W43110399782023 @default.
- W4311039978 crossrefType "journal-article" @default.
- W4311039978 hasAuthorship W4311039978A5008015414 @default.
- W4311039978 hasAuthorship W4311039978A5014525990 @default.
- W4311039978 hasAuthorship W4311039978A5026583601 @default.
- W4311039978 hasAuthorship W4311039978A5028420889 @default.
- W4311039978 hasAuthorship W4311039978A5040042590 @default.
- W4311039978 hasAuthorship W4311039978A5057272765 @default.
- W4311039978 hasAuthorship W4311039978A5061655044 @default.
- W4311039978 hasAuthorship W4311039978A5071269452 @default.
- W4311039978 hasAuthorship W4311039978A5076431272 @default.
- W4311039978 hasAuthorship W4311039978A5077494803 @default.
- W4311039978 hasBestOaLocation W43110399781 @default.
- W4311039978 hasConcept C104317684 @default.
- W4311039978 hasConcept C2776460866 @default.
- W4311039978 hasConcept C2781350384 @default.
- W4311039978 hasConcept C49039625 @default.
- W4311039978 hasConcept C523546767 @default.
- W4311039978 hasConcept C54355233 @default.
- W4311039978 hasConcept C55493867 @default.