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- W4311045165 abstract "Cadmium (Cd) is a widespread environmental toxicant that can cause severe hepatic injury. Oyster protein hydrolysates (OPs) have potential effects on preventing liver disease. In this study, thirty mice were randomly divided into five groups: the control, Cd, Cd + ethylenediaminetetraacetic acid (EDTA, 100 mg/kg), and low/high dose of OPs-treatment groups (100 mg/kg or 300 mg/kg). After continuous administration for 7 days, the ameliorative effect of OPs on Cd-induced acute hepatic injury in Cd-exposed mice was assessed. The results showed that OPs significantly improved the liver function profiles (serum ALT, AST, LDH, and ALP) in Cd-exposed mice. Histopathological analysis showed that OPs decreased apoptotic bodies, hemorrhage, lymphocyte accumulation, and inflammatory cell infiltration around central veins. OPs significantly retained the activities of SOD, CAT, and GSH-Px, and decreased the elevated hepatic MDA content in Cd-exposed mice. In addition, OPs exhibited a reductive effect on the inflammatory responses (IL-1β, IL-6, and TNF-α) and inhibitory effects on the expression of inflammation-related proteins (MIP-2 and COX-2) and the ERK/NF-κB signaling pathway. OPs suppressed the development of hepatocyte apoptosis (Bax, caspase-3, and Blc-2) and the activation of the PI3K/AKT signaling pathway in Cd-exposed mice. In conclusion, OPs ameliorated the Cd-induced hepatic injury by inhibiting oxidative damage and inflammatory responses, as well as the development of hepatocyte apoptosis via regulating the ERK/NF-κB and PI3K/AKT-related signaling pathways." @default.
- W4311045165 created "2022-12-23" @default.
- W4311045165 creator A5017581087 @default.
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- W4311045165 date "2022-11-30" @default.
- W4311045165 modified "2023-10-09" @default.
- W4311045165 title "Ameliorative Effects of Oyster Protein Hydrolysates on Cadmium-Induced Hepatic Injury in Mice" @default.
- W4311045165 cites W144005866 @default.
- W4311045165 cites W1478145143 @default.
- W4311045165 cites W1571310775 @default.
- W4311045165 cites W1601614334 @default.
- W4311045165 cites W1966521314 @default.
- W4311045165 cites W1972035138 @default.
- W4311045165 cites W1974567018 @default.
- W4311045165 cites W1981055137 @default.
- W4311045165 cites W1996752449 @default.
- W4311045165 cites W1998101625 @default.
- W4311045165 cites W2004235656 @default.
- W4311045165 cites W2006848819 @default.
- W4311045165 cites W2008951912 @default.
- W4311045165 cites W2012111244 @default.
- W4311045165 cites W2012310641 @default.
- W4311045165 cites W2013729220 @default.
- W4311045165 cites W2015171124 @default.
- W4311045165 cites W2016757672 @default.
- W4311045165 cites W2018214249 @default.
- W4311045165 cites W2026107262 @default.
- W4311045165 cites W2027029983 @default.
- W4311045165 cites W2039441362 @default.
- W4311045165 cites W2048553024 @default.
- W4311045165 cites W2060388798 @default.
- W4311045165 cites W2068049375 @default.
- W4311045165 cites W2070181523 @default.
- W4311045165 cites W2075758135 @default.
- W4311045165 cites W2076597625 @default.
- W4311045165 cites W2077688462 @default.
- W4311045165 cites W2078932225 @default.
- W4311045165 cites W2085076969 @default.
- W4311045165 cites W2089180073 @default.
- W4311045165 cites W2090126018 @default.
- W4311045165 cites W2095481879 @default.
- W4311045165 cites W2115819658 @default.
- W4311045165 cites W2118334265 @default.
- W4311045165 cites W2143209174 @default.
- W4311045165 cites W2143909404 @default.
- W4311045165 cites W2144231457 @default.
- W4311045165 cites W2153909256 @default.
- W4311045165 cites W2155772701 @default.
- W4311045165 cites W2158915678 @default.
- W4311045165 cites W2159727241 @default.
- W4311045165 cites W2164365729 @default.
- W4311045165 cites W2190264764 @default.
- W4311045165 cites W2236579283 @default.
- W4311045165 cites W2253819322 @default.
- W4311045165 cites W2464992808 @default.
- W4311045165 cites W2465535949 @default.
- W4311045165 cites W2519611314 @default.
- W4311045165 cites W2565489764 @default.
- W4311045165 cites W2626811718 @default.
- W4311045165 cites W2765898479 @default.
- W4311045165 cites W2778267535 @default.
- W4311045165 cites W2809933458 @default.
- W4311045165 cites W2884870079 @default.
- W4311045165 cites W2887598349 @default.
- W4311045165 cites W2891786111 @default.
- W4311045165 cites W2894035079 @default.
- W4311045165 cites W2898862701 @default.
- W4311045165 cites W2899586483 @default.
- W4311045165 cites W2909080269 @default.
- W4311045165 cites W2920884097 @default.
- W4311045165 cites W2938930184 @default.
- W4311045165 cites W2946327155 @default.
- W4311045165 cites W2950841930 @default.
- W4311045165 cites W2954776442 @default.
- W4311045165 cites W2969146370 @default.
- W4311045165 cites W2972725879 @default.
- W4311045165 cites W2980427099 @default.
- W4311045165 cites W2993480192 @default.
- W4311045165 cites W2997452552 @default.
- W4311045165 cites W3010223361 @default.
- W4311045165 cites W3014246738 @default.
- W4311045165 cites W3032637043 @default.
- W4311045165 cites W3034468955 @default.
- W4311045165 cites W3035225837 @default.
- W4311045165 cites W3036382981 @default.
- W4311045165 cites W3113488580 @default.
- W4311045165 cites W3125452140 @default.
- W4311045165 cites W3127029890 @default.
- W4311045165 cites W3128230808 @default.
- W4311045165 cites W3128509602 @default.
- W4311045165 cites W3162665462 @default.
- W4311045165 cites W3176139475 @default.
- W4311045165 cites W3182666626 @default.