FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311053311> ?p ?o ?g. }

• W4311053311 endingPage "3095" @default.
• W4311053311 startingPage "3095" @default.
• W4311053311 abstract "To date, there have been no new drugs or adjuvants able to decrease both morbidity and mortality in the context of sepsis and septic shock. Our objective was to evaluate the use of thiosulfinate-enriched Allium sativum and black garlic extracts as adjuvants in the management of sepsis. An experimental in vivo study was carried out with male Sprague–Dawley® rats. Animals were randomized in four treatment groups: antibiotic (ceftriaxone) treatment (group I), ceftriaxone plus thiosulfinate-enriched extract (TASE, group II), ceftriaxone plus thiosulfinate-enriched extract and black garlic extracts (TASE + BGE, group III), and ceftriaxone plus black garlic extract (BGE, group IV). All animals were housed and inoculated with 1 × 1010 CFU/15 mL of intraperitoneal Escherichia coli ATCC 25922. Subsequently, they received a daily treatment according to each group for 7 days. Clinical, analytical, microbiological, and histopathological parameters were evaluated. Statistically significant clinical improvement was observed in rats receiving garlic extracts in weight (groups II and III), ocular secretions, and piloerection (group IV). Moreover, less liver edema, vacuolization, and inflammation were observed in groups receiving adjuvant support (groups II, III, and IV). When comparing interleukins 24 h after bacteria inoculum, we found statistically significant differences in TNF-alpha levels in groups receiving BGE (groups III and IV, p ≤ 0.05). Blood and peritoneal liquid cultures were also analyzed, and we detected a certain level of Enterococcus faecalis in peritoneal cultures from all treatment groups and less bacteria presence in blood cultures in rats receiving garlic extracts (groups II, III, and IV). In conclusion, TASE and BGE could be promising nutraceutical or medicinal agents as coadjuvants in the treatment of sepsis because of its effects in modulating the inflammatory response." @default.
• W4311053311 created "2022-12-23" @default.
• W4311053311 creator A5027211684 @default.
• W4311053311 creator A5029679467 @default.
• W4311053311 creator A5034172947 @default.
• W4311053311 creator A5036946824 @default.
• W4311053311 creator A5042712944 @default.
• W4311053311 creator A5049530758 @default.
• W4311053311 creator A5055296315 @default.
• W4311053311 creator A5060420607 @default.
• W4311053311 creator A5062584189 @default.
• W4311053311 creator A5072323160 @default.
• W4311053311 creator A5073092755 @default.
• W4311053311 creator A5084402190 @default.
• W4311053311 creator A5090004058 @default.
• W4311053311 date "2022-12-01" @default.
• W4311053311 modified "2023-09-27" @default.
• W4311053311 title "Black Garlic and Thiosulfinate-Enriched Extracts as Adjuvants to Ceftriaxone Treatment in a Rat Peritonitis Model of Sepsis" @default.
• W4311053311 cites W145891161 @default.
• W4311053311 cites W1983389638 @default.
• W4311053311 cites W1988962075 @default.
• W4311053311 cites W1997423398 @default.
• W4311053311 cites W2009080114 @default.
• W4311053311 cites W2010937591 @default.
• W4311053311 cites W2012522637 @default.
• W4311053311 cites W2018882072 @default.
• W4311053311 cites W2021247756 @default.
• W4311053311 cites W2042851093 @default.
• W4311053311 cites W2047451878 @default.
• W4311053311 cites W2048259404 @default.
• W4311053311 cites W2056284242 @default.
• W4311053311 cites W2056411965 @default.
• W4311053311 cites W2058164136 @default.
• W4311053311 cites W2068734008 @default.
• W4311053311 cites W2076262907 @default.
• W4311053311 cites W2081371688 @default.
• W4311053311 cites W2081449047 @default.
• W4311053311 cites W2082101431 @default.
• W4311053311 cites W2083513831 @default.
• W4311053311 cites W2085705777 @default.
• W4311053311 cites W2102372841 @default.
• W4311053311 cites W2103476804 @default.
• W4311053311 cites W2143449091 @default.
• W4311053311 cites W2157977057 @default.
• W4311053311 cites W2159230166 @default.
• W4311053311 cites W2160823360 @default.
• W4311053311 cites W2161771297 @default.
• W4311053311 cites W2272987617 @default.
• W4311053311 cites W2280404143 @default.
• W4311053311 cites W2282181907 @default.
• W4311053311 cites W2326212911 @default.
• W4311053311 cites W2341811425 @default.
• W4311053311 cites W2396835894 @default.
• W4311053311 cites W2414636159 @default.
• W4311053311 cites W2525915767 @default.
• W4311053311 cites W2604270270 @default.
• W4311053311 cites W2617620062 @default.
• W4311053311 cites W2922803436 @default.
• W4311053311 cites W2936847542 @default.
• W4311053311 cites W2989085833 @default.
• W4311053311 cites W2997100646 @default.
• W4311053311 cites W3164486245 @default.
• W4311053311 cites W3202964273 @default.
• W4311053311 cites W4244545582 @default.
• W4311053311 cites W744916421 @default.
• W4311053311 doi "https://doi.org/10.3390/biomedicines10123095" @default.
• W4311053311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36551850" @default.
• W4311053311 hasPublicationYear "2022" @default.
• W4311053311 type Work @default.
• W4311053311 citedByCount "1" @default.
• W4311053311 countsByYear W43110533112023 @default.
• W4311053311 crossrefType "journal-article" @default.
• W4311053311 hasAuthorship W4311053311A5027211684 @default.
• W4311053311 hasAuthorship W4311053311A5029679467 @default.
• W4311053311 hasAuthorship W4311053311A5034172947 @default.
• W4311053311 hasAuthorship W4311053311A5036946824 @default.
• W4311053311 hasAuthorship W4311053311A5042712944 @default.
• W4311053311 hasAuthorship W4311053311A5049530758 @default.
• W4311053311 hasAuthorship W4311053311A5055296315 @default.
• W4311053311 hasAuthorship W4311053311A5060420607 @default.
• W4311053311 hasAuthorship W4311053311A5062584189 @default.
• W4311053311 hasAuthorship W4311053311A5072323160 @default.
• W4311053311 hasAuthorship W4311053311A5073092755 @default.
• W4311053311 hasAuthorship W4311053311A5084402190 @default.
• W4311053311 hasAuthorship W4311053311A5090004058 @default.
• W4311053311 hasBestOaLocation W43110533111 @default.
• W4311053311 hasConcept C126322002 @default.
• W4311053311 hasConcept C151730666 @default.
• W4311053311 hasConcept C2776520383 @default.
• W4311053311 hasConcept C2778384902 @default.
• W4311053311 hasConcept C2779343474 @default.
• W4311053311 hasConcept C2779489039 @default.
• W4311053311 hasConcept C2779895986 @default.
• W4311053311 hasConcept C2780199535 @default.
• W4311053311 hasConcept C501593827 @default.
• W4311053311 hasConcept C523546767 @default.
• W4311053311 hasConcept C54355233 @default.
• W4311053311 hasConcept C71924100 @default.

• next