Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311054797> ?p ?o ?g. }
- W4311054797 endingPage "3103" @default.
- W4311054797 startingPage "3103" @default.
- W4311054797 abstract "Lafora disease (LD) is a neurodegenerative condition characterized by the accumulation of polyglucosan bodies (PBs) throughout the brain. Alongside metabolic and molecular alterations, neuroinflammation has emerged as another key histopathological feature of LD.To investigate the role of astrocytes and microglia in LD, we performed a systematic review according to the PRISMA statement. PubMed, Scopus, and Web-of-Science database searches were performed independently by two reviewers.Thirty-five studies analyzing the relationship of astrocytes and microglia with LD and/or the effects of anti-inflammatory treatments in LD animal models were identified and included in the review. Although LD has long been dominated by a neuronocentric view, a growing body of evidence suggests a role of glial cells in the disease, starting with the finding that these cells accumulate PBs. We discuss the potential meaning of glial PB accumulations, the likely factors activating glial cells, and the possible contribution of glial cells to LD neurodegeneration and epilepsy.Given the evidence for the role of neuroinflammation in LD, future studies should consider glial cells as a potential therapeutic target for modifying/delaying LD progression; however, it should be kept in mind that these cells can potentially assume multiple reactive phenotypes, which could influence the therapeutic response." @default.
- W4311054797 created "2022-12-23" @default.
- W4311054797 creator A5068237948 @default.
- W4311054797 creator A5084350771 @default.
- W4311054797 creator A5084737419 @default.
- W4311054797 date "2022-12-01" @default.
- W4311054797 modified "2023-09-26" @default.
- W4311054797 title "Glial Contributions to Lafora Disease: A Systematic Review" @default.
- W4311054797 cites W1569924411 @default.
- W4311054797 cites W1584056801 @default.
- W4311054797 cites W1907777909 @default.
- W4311054797 cites W1965942744 @default.
- W4311054797 cites W1971200109 @default.
- W4311054797 cites W1978075301 @default.
- W4311054797 cites W1978829102 @default.
- W4311054797 cites W1983314236 @default.
- W4311054797 cites W1986195187 @default.
- W4311054797 cites W1997353282 @default.
- W4311054797 cites W2000295352 @default.
- W4311054797 cites W2016631802 @default.
- W4311054797 cites W2023558816 @default.
- W4311054797 cites W2027857376 @default.
- W4311054797 cites W2038078341 @default.
- W4311054797 cites W2046991618 @default.
- W4311054797 cites W2049675290 @default.
- W4311054797 cites W2050320551 @default.
- W4311054797 cites W2051075231 @default.
- W4311054797 cites W2057334342 @default.
- W4311054797 cites W2058969830 @default.
- W4311054797 cites W2059184056 @default.
- W4311054797 cites W2061673947 @default.
- W4311054797 cites W2066675587 @default.
- W4311054797 cites W2066759203 @default.
- W4311054797 cites W2068597324 @default.
- W4311054797 cites W2068687319 @default.
- W4311054797 cites W2074147499 @default.
- W4311054797 cites W2075110274 @default.
- W4311054797 cites W2085325605 @default.
- W4311054797 cites W2087243986 @default.
- W4311054797 cites W2090848516 @default.
- W4311054797 cites W2093589803 @default.
- W4311054797 cites W2095018951 @default.
- W4311054797 cites W2096327192 @default.
- W4311054797 cites W2098038342 @default.
- W4311054797 cites W2102873804 @default.
- W4311054797 cites W2104504339 @default.
- W4311054797 cites W2109015289 @default.
- W4311054797 cites W2111271085 @default.
- W4311054797 cites W2113744947 @default.
- W4311054797 cites W2115632183 @default.
- W4311054797 cites W2126722763 @default.
- W4311054797 cites W2131872983 @default.
- W4311054797 cites W2138554422 @default.
- W4311054797 cites W2147180300 @default.
- W4311054797 cites W2149239016 @default.
- W4311054797 cites W2153524819 @default.
- W4311054797 cites W2153703070 @default.
- W4311054797 cites W2157062516 @default.
- W4311054797 cites W2157796001 @default.
- W4311054797 cites W2161491363 @default.
- W4311054797 cites W2164924935 @default.
- W4311054797 cites W2165108752 @default.
- W4311054797 cites W2167881747 @default.
- W4311054797 cites W2170485551 @default.
- W4311054797 cites W2193115302 @default.
- W4311054797 cites W2238460669 @default.
- W4311054797 cites W2289098957 @default.
- W4311054797 cites W2299031235 @default.
- W4311054797 cites W2301368457 @default.
- W4311054797 cites W2302083665 @default.
- W4311054797 cites W2314634699 @default.
- W4311054797 cites W2331403525 @default.
- W4311054797 cites W2340549461 @default.
- W4311054797 cites W2417817981 @default.
- W4311054797 cites W2489319194 @default.
- W4311054797 cites W2507842763 @default.
- W4311054797 cites W2515408417 @default.
- W4311054797 cites W2527523087 @default.
- W4311054797 cites W2527645962 @default.
- W4311054797 cites W2572710398 @default.
- W4311054797 cites W2573218393 @default.
- W4311054797 cites W2583168382 @default.
- W4311054797 cites W2585264447 @default.
- W4311054797 cites W2589367062 @default.
- W4311054797 cites W2622807556 @default.
- W4311054797 cites W2700330585 @default.
- W4311054797 cites W2725043130 @default.
- W4311054797 cites W2744877759 @default.
- W4311054797 cites W2755203299 @default.
- W4311054797 cites W2789489194 @default.
- W4311054797 cites W2790245192 @default.
- W4311054797 cites W2792182131 @default.
- W4311054797 cites W2792689216 @default.
- W4311054797 cites W2792813804 @default.
- W4311054797 cites W2792857412 @default.
- W4311054797 cites W2797279856 @default.
- W4311054797 cites W2797384836 @default.
- W4311054797 cites W2804685648 @default.