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- W4311091397 abstract "Melanoma is the deadliest form of skin cancer. It is classified as cutaneous and non-cutaneous, with the former characterized by developing in sun-exposed areas of the skin, UV-light radiation being its most important risk factor and ordinarily affecting fair skin populations. In recent years, the incidence of melanoma has been increasing in populations with darker complexion, for example, Hispanics, in which acral melanoma is highly prevalent. The WHO estimates that the incidence and mortality of melanoma will increase by more than 60% by 2040, particularly in low/medium income countries. Acral melanoma appears in the palms, soles and nails, and because of these occult locations, it is often considered different from other cutaneous melanomas even though it also originates in the skin. Acral melanoma is very rare in Caucasian populations and is often not included from genetic analysis and clinical trials. In this review, we present the worldwide epidemiology of acral melanoma; we summarize its genetic characterization and point out important signaling pathways for targeted therapy. We also discuss how genetic analyses have shown that acral melanoma carries a sufficient mutational load and neoantigen formation to be targeted by the immune system, arguing for a potential benefit with novel immunotherapeutic strategies, alone or combined with targeted therapy. This is important because chemotherapy remains the first-line treatment in non-developed nations despite a disheartening response. In summary, the increased incidence and mortality of acral melanoma in low/medium income countries calls for increasing our knowledge about its nature and therapeutic options and leveling off the asymmetric research conducted primarily on Caucasian populations." @default.
- W4311091397 created "2022-12-23" @default.
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- W4311091397 date "2022-12-01" @default.
- W4311091397 modified "2023-10-01" @default.
- W4311091397 title "Immunotherapy Options for Acral Melanoma, A fast-growing but Neglected Malignancy" @default.
- W4311091397 cites W117283996 @default.
- W4311091397 cites W127707871 @default.
- W4311091397 cites W1487350429 @default.
- W4311091397 cites W1487600162 @default.
- W4311091397 cites W1507055111 @default.
- W4311091397 cites W1950829641 @default.
- W4311091397 cites W1996579961 @default.
- W4311091397 cites W2005465491 @default.
- W4311091397 cites W2028466308 @default.
- W4311091397 cites W2046972425 @default.
- W4311091397 cites W2048628504 @default.
- W4311091397 cites W2055118638 @default.
- W4311091397 cites W2063725270 @default.
- W4311091397 cites W2068237418 @default.
- W4311091397 cites W2096223992 @default.
- W4311091397 cites W2098492855 @default.
- W4311091397 cites W2102352867 @default.
- W4311091397 cites W2103152130 @default.
- W4311091397 cites W2103549763 @default.
- W4311091397 cites W2107321795 @default.
- W4311091397 cites W2109274792 @default.
- W4311091397 cites W2112121482 @default.
- W4311091397 cites W2113912808 @default.
- W4311091397 cites W2123628301 @default.
- W4311091397 cites W2128542677 @default.
- W4311091397 cites W2132923173 @default.
- W4311091397 cites W2140715248 @default.
- W4311091397 cites W2144096834 @default.
- W4311091397 cites W2152897456 @default.
- W4311091397 cites W2166050321 @default.
- W4311091397 cites W2169977177 @default.
- W4311091397 cites W2300492004 @default.
- W4311091397 cites W2328342763 @default.
- W4311091397 cites W2339984867 @default.
- W4311091397 cites W2427476638 @default.
- W4311091397 cites W2519469881 @default.
- W4311091397 cites W2553340100 @default.
- W4311091397 cites W2559127842 @default.
- W4311091397 cites W2592369722 @default.
- W4311091397 cites W2597581482 @default.
- W4311091397 cites W2747107882 @default.
- W4311091397 cites W2748716584 @default.
- W4311091397 cites W2749616442 @default.
- W4311091397 cites W2766512176 @default.
- W4311091397 cites W2791686077 @default.
- W4311091397 cites W2810292296 @default.
- W4311091397 cites W2898336689 @default.
- W4311091397 cites W2900046418 @default.
- W4311091397 cites W2902153433 @default.
- W4311091397 cites W2902952415 @default.
- W4311091397 cites W2910849865 @default.
- W4311091397 cites W2912374321 @default.
- W4311091397 cites W2913375082 @default.
- W4311091397 cites W2939676267 @default.
- W4311091397 cites W2948662515 @default.
- W4311091397 cites W2948884915 @default.
- W4311091397 cites W2963398239 @default.
- W4311091397 cites W2965059444 @default.
- W4311091397 cites W2967805215 @default.
- W4311091397 cites W2976652879 @default.
- W4311091397 cites W2998606381 @default.
- W4311091397 cites W2999869004 @default.
- W4311091397 cites W3014701396 @default.
- W4311091397 cites W3016280944 @default.
- W4311091397 cites W3018788215 @default.
- W4311091397 cites W3033841343 @default.
- W4311091397 cites W3033948992 @default.
- W4311091397 cites W3080499403 @default.
- W4311091397 cites W3085521743 @default.
- W4311091397 cites W3086117981 @default.
- W4311091397 cites W3092852290 @default.
- W4311091397 cites W3094973931 @default.
- W4311091397 cites W3104413058 @default.
- W4311091397 cites W3119504584 @default.
- W4311091397 cites W3166578944 @default.
- W4311091397 cites W3173401695 @default.
- W4311091397 cites W3176713552 @default.
- W4311091397 cites W3189025068 @default.
- W4311091397 cites W3194412282 @default.
- W4311091397 cites W3214993276 @default.
- W4311091397 cites W4211115699 @default.
- W4311091397 cites W4220913055 @default.
- W4311091397 cites W4226181406 @default.
- W4311091397 cites W4226258201 @default.
- W4311091397 cites W4281657610 @default.
- W4311091397 cites W4289755156 @default.