FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311101872> ?p ?o ?g. }

• W4311101872 endingPage "e14472" @default.
• W4311101872 startingPage "e14472" @default.
• W4311101872 abstract "Spermatogenesis and sperm maturation are complex and highly ordered biological processes. Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability. Cathepsin B (CTSB) is involved in the regulation of a variety of pathological processes. In the present study, we found that CTSB was abundantly expressed in the male reproductive system, however, the specific role of CTSB in regulating spermatogenesis and sperm maturation remained elusive. Hence, we generated Ctsb-/- mice using CRISPR/Cas9 technology. In Ctsb-/- mice, sperm count was significantly decreased while the level of morphologically abnormal sperm was markedly increased. Additionally, these mice had significantly lower levels of progressive motility sperm and elevated levels of immobilized sperm. Histological analysis showed slight vacuolization in the testis epithelium, as well as the loss of epididymal epithelium cells. Further investigation showed that autophagic activity was inhibited and apoptotic activity was increased in both the testis and epididymis of Ctsb-/- mice. Together, our findings demonstrate that CTSB plays an important role in spermatogenesis and sperm maturation in mice." @default.
• W4311101872 created "2022-12-23" @default.
• W4311101872 creator A5000977982 @default.
• W4311101872 creator A5008374685 @default.
• W4311101872 creator A5017353282 @default.
• W4311101872 creator A5018886803 @default.
• W4311101872 creator A5069713717 @default.
• W4311101872 creator A5074484162 @default.
• W4311101872 creator A5076720259 @default.
• W4311101872 creator A5079510247 @default.
• W4311101872 creator A5079528333 @default.
• W4311101872 creator A5084206609 @default.
• W4311101872 date "2022-12-02" @default.
• W4311101872 modified "2023-09-30" @default.
• W4311101872 title "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice" @default.
• W4311101872 cites W1977892883 @default.
• W4311101872 cites W2005568203 @default.
• W4311101872 cites W2012144629 @default.
• W4311101872 cites W2012362519 @default.
• W4311101872 cites W2018210037 @default.
• W4311101872 cites W2078911476 @default.
• W4311101872 cites W2094947007 @default.
• W4311101872 cites W2101742819 @default.
• W4311101872 cites W2149117400 @default.
• W4311101872 cites W2288357900 @default.
• W4311101872 cites W2326727280 @default.
• W4311101872 cites W2347120526 @default.
• W4311101872 cites W2433086811 @default.
• W4311101872 cites W2435911538 @default.
• W4311101872 cites W2469622150 @default.
• W4311101872 cites W2470343227 @default.
• W4311101872 cites W2520306567 @default.
• W4311101872 cites W2559307267 @default.
• W4311101872 cites W2740003321 @default.
• W4311101872 cites W2749156769 @default.
• W4311101872 cites W2793558613 @default.
• W4311101872 cites W2885879910 @default.
• W4311101872 cites W2887491409 @default.
• W4311101872 cites W2896680898 @default.
• W4311101872 cites W2898226458 @default.
• W4311101872 cites W2916664436 @default.
• W4311101872 cites W2942037024 @default.
• W4311101872 cites W2982826615 @default.
• W4311101872 cites W2989859078 @default.
• W4311101872 cites W3002644491 @default.
• W4311101872 cites W3016135362 @default.
• W4311101872 cites W3022869253 @default.
• W4311101872 cites W3043398618 @default.
• W4311101872 cites W3120532369 @default.
• W4311101872 cites W3135251163 @default.
• W4311101872 cites W3192759647 @default.
• W4311101872 cites W3194039441 @default.
• W4311101872 cites W3211029166 @default.
• W4311101872 cites W4205876457 @default.
• W4311101872 cites W4207064014 @default.
• W4311101872 doi "https://doi.org/10.7717/peerj.14472" @default.
• W4311101872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36518274" @default.
• W4311101872 hasPublicationYear "2022" @default.
• W4311101872 type Work @default.
• W4311101872 citedByCount "0" @default.
• W4311101872 crossrefType "journal-article" @default.
• W4311101872 hasAuthorship W4311101872A5000977982 @default.
• W4311101872 hasAuthorship W4311101872A5008374685 @default.
• W4311101872 hasAuthorship W4311101872A5017353282 @default.
• W4311101872 hasAuthorship W4311101872A5018886803 @default.
• W4311101872 hasAuthorship W4311101872A5069713717 @default.
• W4311101872 hasAuthorship W4311101872A5074484162 @default.
• W4311101872 hasAuthorship W4311101872A5076720259 @default.
• W4311101872 hasAuthorship W4311101872A5079510247 @default.
• W4311101872 hasAuthorship W4311101872A5079528333 @default.
• W4311101872 hasAuthorship W4311101872A5084206609 @default.
• W4311101872 hasBestOaLocation W43111018721 @default.
• W4311101872 hasConcept C123765429 @default.
• W4311101872 hasConcept C134018914 @default.
• W4311101872 hasConcept C16685009 @default.
• W4311101872 hasConcept C181199279 @default.
• W4311101872 hasConcept C2777632594 @default.
• W4311101872 hasConcept C2781087480 @default.
• W4311101872 hasConcept C2781254305 @default.
• W4311101872 hasConcept C28021979 @default.
• W4311101872 hasConcept C54355233 @default.
• W4311101872 hasConcept C55493867 @default.
• W4311101872 hasConcept C58207958 @default.
• W4311101872 hasConcept C71924100 @default.
• W4311101872 hasConcept C86803240 @default.
• W4311101872 hasConcept C95444343 @default.
• W4311101872 hasConceptScore W4311101872C123765429 @default.
• W4311101872 hasConceptScore W4311101872C134018914 @default.
• W4311101872 hasConceptScore W4311101872C16685009 @default.
• W4311101872 hasConceptScore W4311101872C181199279 @default.
• W4311101872 hasConceptScore W4311101872C2777632594 @default.
• W4311101872 hasConceptScore W4311101872C2781087480 @default.
• W4311101872 hasConceptScore W4311101872C2781254305 @default.
• W4311101872 hasConceptScore W4311101872C28021979 @default.
• W4311101872 hasConceptScore W4311101872C54355233 @default.
• W4311101872 hasConceptScore W4311101872C55493867 @default.
• W4311101872 hasConceptScore W4311101872C58207958 @default.
• W4311101872 hasConceptScore W4311101872C71924100 @default.

• next