Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311102016> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4311102016 abstract "Abstract The health risks posed by excessive visceral white adipose tissue (WAT) may arise from exposure to deleterious intestinal factors in transit through the portal system. These may include an altered bile acid (BA) pool – particularly with respect to 12α-hydroxylated BA (12-HBA), which we have previously demonstrated are closely associated with insulin resistance. However, given the complexity of the enterohepatic milieu, we have worked to develop a co-culture system that allows for controlled study of the interactions between human induced pluripotent stem cell (hiPSC) derived adipocytes and primary human intestinal organoids (hIO). We present preliminary data on the characterization of both cellular compartments and their interactions, particularly in the context of BA treatment. We have recapitulated the basic functionality of each tissue type and have found reciprocal, potentially important changes in gene expression in each. However, we also have encountered numerous technical challenges in the development of this co-culture system and provide methodological observations to assist others seeking to work with a co-culture system of this type." @default.
- W4311102016 created "2022-12-23" @default.
- W4311102016 creator A5028080090 @default.
- W4311102016 creator A5077704681 @default.
- W4311102016 creator A5083380368 @default.
- W4311102016 date "2022-12-01" @default.
- W4311102016 modified "2023-10-14" @default.
- W4311102016 title "Toward a Cell Culture Model of Portal Axis Lipid Handling" @default.
- W4311102016 cites W1512522692 @default.
- W4311102016 cites W1555526329 @default.
- W4311102016 cites W1967847161 @default.
- W4311102016 cites W2052406310 @default.
- W4311102016 cites W2054462517 @default.
- W4311102016 cites W2104004584 @default.
- W4311102016 cites W2107684418 @default.
- W4311102016 cites W2145323170 @default.
- W4311102016 cites W2153570040 @default.
- W4311102016 cites W2156899647 @default.
- W4311102016 cites W2170158688 @default.
- W4311102016 cites W2260577542 @default.
- W4311102016 cites W2285677406 @default.
- W4311102016 cites W2329468673 @default.
- W4311102016 cites W2418348567 @default.
- W4311102016 cites W2504965130 @default.
- W4311102016 cites W2571158149 @default.
- W4311102016 cites W2584489823 @default.
- W4311102016 cites W2604117018 @default.
- W4311102016 cites W2656341959 @default.
- W4311102016 cites W2800295644 @default.
- W4311102016 cites W2912039947 @default.
- W4311102016 cites W2971480087 @default.
- W4311102016 cites W2980938396 @default.
- W4311102016 cites W3006520127 @default.
- W4311102016 cites W3008279587 @default.
- W4311102016 cites W3045462993 @default.
- W4311102016 cites W3086482718 @default.
- W4311102016 cites W3109836655 @default.
- W4311102016 cites W4211240480 @default.
- W4311102016 cites W4287980880 @default.
- W4311102016 cites W943734564 @default.
- W4311102016 doi "https://doi.org/10.1101/2022.11.30.518512" @default.
- W4311102016 hasPublicationYear "2022" @default.
- W4311102016 type Work @default.
- W4311102016 citedByCount "0" @default.
- W4311102016 crossrefType "posted-content" @default.
- W4311102016 hasAuthorship W4311102016A5028080090 @default.
- W4311102016 hasAuthorship W4311102016A5077704681 @default.
- W4311102016 hasAuthorship W4311102016A5083380368 @default.
- W4311102016 hasBestOaLocation W43111020161 @default.
- W4311102016 hasConcept C104317684 @default.
- W4311102016 hasConcept C107459253 @default.
- W4311102016 hasConcept C134018914 @default.
- W4311102016 hasConcept C145103041 @default.
- W4311102016 hasConcept C151730666 @default.
- W4311102016 hasConcept C151955695 @default.
- W4311102016 hasConcept C171089720 @default.
- W4311102016 hasConcept C2779343474 @default.
- W4311102016 hasConcept C31695470 @default.
- W4311102016 hasConcept C54355233 @default.
- W4311102016 hasConcept C55493867 @default.
- W4311102016 hasConcept C70721500 @default.
- W4311102016 hasConcept C81885089 @default.
- W4311102016 hasConcept C86803240 @default.
- W4311102016 hasConcept C95444343 @default.
- W4311102016 hasConceptScore W4311102016C104317684 @default.
- W4311102016 hasConceptScore W4311102016C107459253 @default.
- W4311102016 hasConceptScore W4311102016C134018914 @default.
- W4311102016 hasConceptScore W4311102016C145103041 @default.
- W4311102016 hasConceptScore W4311102016C151730666 @default.
- W4311102016 hasConceptScore W4311102016C151955695 @default.
- W4311102016 hasConceptScore W4311102016C171089720 @default.
- W4311102016 hasConceptScore W4311102016C2779343474 @default.
- W4311102016 hasConceptScore W4311102016C31695470 @default.
- W4311102016 hasConceptScore W4311102016C54355233 @default.
- W4311102016 hasConceptScore W4311102016C55493867 @default.
- W4311102016 hasConceptScore W4311102016C70721500 @default.
- W4311102016 hasConceptScore W4311102016C81885089 @default.
- W4311102016 hasConceptScore W4311102016C86803240 @default.
- W4311102016 hasConceptScore W4311102016C95444343 @default.
- W4311102016 hasLocation W43111020161 @default.
- W4311102016 hasOpenAccess W4311102016 @default.
- W4311102016 hasPrimaryLocation W43111020161 @default.
- W4311102016 hasRelatedWork W1992851492 @default.
- W4311102016 hasRelatedWork W2472802576 @default.
- W4311102016 hasRelatedWork W2803201318 @default.
- W4311102016 hasRelatedWork W3016562585 @default.
- W4311102016 hasRelatedWork W3111289286 @default.
- W4311102016 hasRelatedWork W3194233175 @default.
- W4311102016 hasRelatedWork W4220987363 @default.
- W4311102016 hasRelatedWork W4280528014 @default.
- W4311102016 hasRelatedWork W4311630974 @default.
- W4311102016 hasRelatedWork W4323652098 @default.
- W4311102016 isParatext "false" @default.
- W4311102016 isRetracted "false" @default.
- W4311102016 workType "article" @default.