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- W4311103815 abstract "Abstract Small-molecule tyrosine kinase inhibitors (TKIs) represent a potentially powerful approach to the treatment of osteosarcoma (OS). However, dose-limiting toxicity, therapeutic efficacy, and targeting specificity are significant barriers to the use of TKIs in the clinic. Notably among TKIs, ponatinib demonstrated potent anti-tumor activity; however, it received an FDA black box warning for potential side effects. We propose ponatinib-loaded biomimetic nanoparticles (NPs) to repurpose ponatinib as an efficient therapeutic option for OS. In this study, we demonstrate enhanced targeting ability and maintain potent ponatinib nano-therapeutic activity, while also reducing toxicity. In in vitro two- and three-dimensional models, we demonstrate that ponatinib-loaded biomimetic NPs maintain the efficacy of the free drug, while in vivo we show that they can improve tumor targeting, slow tumor growth, and reduce evidence of systemic toxicities. Though there is limited Pon encapsulation within NPs, this platform may improve current therapeutic approaches and reduce dosage-related side effects to achieve better clinical outcomes in OS patients. Graphical Abstract" @default.
- W4311103815 created "2022-12-23" @default.
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- W4311103815 date "2022-12-01" @default.
- W4311103815 modified "2023-09-26" @default.
- W4311103815 title "Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma" @default.
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- W4311103815 cites W1996634925 @default.
- W4311103815 cites W2027366356 @default.
- W4311103815 cites W2044722516 @default.
- W4311103815 cites W2062265555 @default.
- W4311103815 cites W2081341733 @default.
- W4311103815 cites W2085652943 @default.
- W4311103815 cites W2087612350 @default.
- W4311103815 cites W2106409672 @default.
- W4311103815 cites W2118783447 @default.
- W4311103815 cites W2119760603 @default.
- W4311103815 cites W2123101856 @default.
- W4311103815 cites W2145369004 @default.
- W4311103815 cites W2164650822 @default.
- W4311103815 cites W2406375428 @default.
- W4311103815 cites W2548868124 @default.
- W4311103815 cites W2549976854 @default.
- W4311103815 cites W2592013183 @default.
- W4311103815 cites W2605307592 @default.
- W4311103815 cites W2725918878 @default.
- W4311103815 cites W2753471766 @default.
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- W4311103815 cites W2789493946 @default.
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- W4311103815 cites W2791844198 @default.
- W4311103815 cites W2793211769 @default.
- W4311103815 cites W2794573030 @default.
- W4311103815 cites W2795389019 @default.
- W4311103815 cites W2884126108 @default.
- W4311103815 cites W2897044304 @default.
- W4311103815 cites W2899285497 @default.
- W4311103815 cites W2900121309 @default.
- W4311103815 cites W2908990432 @default.
- W4311103815 cites W2920190085 @default.
- W4311103815 cites W2931547116 @default.
- W4311103815 cites W2940164614 @default.
- W4311103815 cites W2955145193 @default.
- W4311103815 cites W2955283253 @default.
- W4311103815 cites W2981355611 @default.
- W4311103815 cites W2982722849 @default.
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- W4311103815 cites W3002003499 @default.
- W4311103815 cites W3036124418 @default.
- W4311103815 cites W3066461590 @default.
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- W4311103815 doi "https://doi.org/10.1186/s12645-022-00146-7" @default.
- W4311103815 hasPublicationYear "2022" @default.
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