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• W4311116243 abstract "Background: The albumin levels may potentially be used as a prognostic biomarker in patients with cancertreated with immune checkpoint inhibitors (ICIs) due to its close relationship with nutritional and inflammatory status. However, the available data is limited with heterogeneous patient cohorts, sample sizes and variable cut-offs. Therefore, we conducted a systematic review and meta-analysis to evaluate the association between survival outcomes and albumin levels in patients treated with ICIs. Methods: We conducted a systematic review using the PubMed, Web of Science, and Embase databases to filter the published studies up to 1 June 2022. The meta-analyses were performed with the generic inverse-variance method with a random-effects model due to the high degree of heterogeneity. The primary outcome measure was hazard ratio (HR) with 95% confidence intervals (CI). The study protocol was registered with the PROSPERO registry (Registration Number: CRD42022337746). Results: Thirty-six studies encompassing 8406 cancer patients with advanced disease were included in the meta-analyses. Almost half of the studies were conducted in NSCLC cohorts (n = 15), and 3.5 gr/dL was the most frequently used albumin cut-off in the included studies (n = 20). Patients with lower albumin levels had a significantly increased risk of death (HR: 1.65, 95% CI: 1.52-1.80, p < 0.0001) than patients with higher albumin levels. Subgroup analyses for study location, sample size, tumor type and albumin cut-off were demonstrated consistent results. Furthermore, in the subgroup analysis of eight studies using albumin levels as a continuous prognostic factor, every 1 gr/dL decrease in albumin levels was associated with significantly increased risk of death by a factor of 10% (HR: 1.10, 95% CI: 1.05-1.16, p = 0.0002). Similar to analyses with overall survival, the patients with lower albumin levels had an increased risk of progression or death compared to patients with higher albumin levels (HR: 1.76, 95% CI: 1.40-2.21, p < 0.001). Conclusion: The available evidence demonstrates that albumin levels may be a prognostic biomarker in advanced cancer patients treated with ICIs. Further research is needed to delineate the role of albumin levels in patients treated with ICIs in the adjuvant setting, as well as the possible benefit of therapeutic approaches to improve hypoalbuminemia." @default.
• W4311116243 created "2022-12-23" @default.
• W4311116243 creator A5016268842 @default.
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• W4311116243 creator A5053670045 @default.
• W4311116243 creator A5056813216 @default.
• W4311116243 creator A5076720762 @default.
• W4311116243 date "2022-12-02" @default.
• W4311116243 modified "2023-10-17" @default.
• W4311116243 title "The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis" @default.
• W4311116243 cites W1765933542 @default.
• W4311116243 cites W1979423827 @default.
• W4311116243 cites W2079725791 @default.
• W4311116243 cites W2097995306 @default.
• W4311116243 cites W2167127503 @default.
• W4311116243 cites W2332385099 @default.
• W4311116243 cites W2384032641 @default.
• W4311116243 cites W2488012409 @default.
• W4311116243 cites W2588681363 @default.
• W4311116243 cites W2606157685 @default.
• W4311116243 cites W2748446166 @default.
• W4311116243 cites W2757618260 @default.
• W4311116243 cites W2769485533 @default.
• W4311116243 cites W2784283849 @default.
• W4311116243 cites W2793364080 @default.
• W4311116243 cites W2797309423 @default.
• W4311116243 cites W2895009116 @default.
• W4311116243 cites W2902220181 @default.
• W4311116243 cites W2903686952 @default.
• W4311116243 cites W2913496992 @default.
• W4311116243 cites W2914335731 @default.
• W4311116243 cites W2925815206 @default.
• W4311116243 cites W2941941303 @default.
• W4311116243 cites W2947159010 @default.
• W4311116243 cites W2948541676 @default.
• W4311116243 cites W2952065098 @default.
• W4311116243 cites W2970160545 @default.
• W4311116243 cites W2970170987 @default.
• W4311116243 cites W2981790403 @default.
• W4311116243 cites W2996681083 @default.
• W4311116243 cites W3004487982 @default.
• W4311116243 cites W3006138994 @default.
• W4311116243 cites W3006322819 @default.
• W4311116243 cites W3017731388 @default.
• W4311116243 cites W3023081021 @default.
• W4311116243 cites W3027035691 @default.
• W4311116243 cites W3028523516 @default.
• W4311116243 cites W3029137192 @default.
• W4311116243 cites W3042157765 @default.
• W4311116243 cites W3045946240 @default.
• W4311116243 cites W3082015903 @default.
• W4311116243 cites W3092921002 @default.
• W4311116243 cites W3095710530 @default.
• W4311116243 cites W3108853735 @default.
• W4311116243 cites W3117264097 @default.
• W4311116243 cites W3118615836 @default.
• W4311116243 cites W3118924526 @default.
• W4311116243 cites W3119508758 @default.
• W4311116243 cites W3129350988 @default.
• W4311116243 cites W3131100289 @default.
• W4311116243 cites W3131288861 @default.
• W4311116243 cites W3136367206 @default.
• W4311116243 cites W3139470044 @default.
• W4311116243 cites W3148827278 @default.
• W4311116243 cites W3159113597 @default.
• W4311116243 cites W3161584863 @default.
• W4311116243 cites W3162404444 @default.
• W4311116243 cites W3163995648 @default.
• W4311116243 cites W3169937598 @default.
• W4311116243 cites W3170392221 @default.
• W4311116243 cites W3174298209 @default.
• W4311116243 cites W3176474008 @default.
• W4311116243 cites W3181460492 @default.
• W4311116243 cites W3183880545 @default.
• W4311116243 cites W3193404084 @default.
• W4311116243 cites W3196861824 @default.
• W4311116243 cites W3197574921 @default.
• W4311116243 cites W3203270526 @default.
• W4311116243 cites W3204087606 @default.
• W4311116243 cites W3204116743 @default.
• W4311116243 cites W3215323648 @default.
• W4311116243 cites W3217429522 @default.
• W4311116243 cites W4200129924 @default.
• W4311116243 cites W4200422150 @default.
• W4311116243 cites W4200494868 @default.
• W4311116243 cites W4205315499 @default.
• W4311116243 cites W4206700113 @default.
• W4311116243 cites W4206761390 @default.
• W4311116243 cites W4210715688 @default.
• W4311116243 cites W4210940367 @default.
• W4311116243 cites W4214895371 @default.
• W4311116243 cites W4220887265 @default.
• W4311116243 cites W4220904951 @default.
• W4311116243 cites W4223434510 @default.
• W4311116243 cites W4224313453 @default.
• W4311116243 cites W4280530207 @default.
• W4311116243 cites W4281718938 @default.
• W4311116243 cites W4282032963 @default.

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