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• W4311123076 abstract "Abstract Background Interferon (IFN) regulatory factors (IRFs) is a kind of transcription factors, which play an important role in regulating the expression of type I IFN and related genes. In mammals, IRF6 is not relevant with IFN expression, while zebrafish IRF6 was reported to be a positive regulator of IFN expression and could be phosphorylated by both MyD88 and TBK1. However, the role of IRF6 in the immune response and IFN transcription of common carp is unknown. Results In the present study, the cDNA of IRF6 gene ( Cc IRF6) was cloned from common carp using RACE technique, with a total length of 1905 bp, encoding 471 amino acid residues, which possesses two functional domains of DBD and IAD. Similarity analysis showed that Cc IRF6 had more than 50% similarity with IRFs of other vertebrates, and had the highest similarity with grass carp and zebrafish, among which the DBD domain was much more conserved. The phylogenetic analysis showed that Cc IRF6 is in the branch of Osteichthyes and has the closest relationship with grass carp. In healthy common carp, the Cc IRF6 was expressed in all the examined tissues, with the highest level in the oral epithelium, and the lowest level in the head kidney. After intraperitoneal injection of poly(I:C) or Aeromonas hydrophila , the expression of Cc IRF6 increased in spleen, head kidney, foregut and hindgut of common carp. Moreover, poly(I:C), LPS, PGN and flagellin induced the expression of Cc IRF6 in peripheral leukocytes and head kidney leukocytes of common carp in vitro. In EPC cells, Cc IRF6 inhibited the expression of some IFN-related genes and pro-inflammatory cytokines, and dual luciferase reporter assay showed that Cc IRF6 reduced the activity of IFN and NF-κB reporter genes. Conclusions The present study suggests that Cc IRF6 is involved in the antiviral and antibacterial immune response of common carp, and negatively regulate the expression of IFN and NF-κB signalling pathways, which provides a theoretical basis for the study and prevention of fish disease pathogenesis." @default.
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• W4311123076 date "2022-12-12" @default.
• W4311123076 modified "2023-10-15" @default.
• W4311123076 title "Negative regulation of interferon regulatory factor 6 (IRF6) in interferon and NF-κB signalling pathways of common carp (Cyprinus carpio L.)" @default.
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• W4311123076 doi "https://doi.org/10.1186/s12917-022-03538-4" @default.
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