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- W4311125931 endingPage "1758" @default.
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- W4311125931 abstract "Abstract Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel pharmacotherapies to treat CVD, particularly atherosclerosis. Effective mechanism-informed development and translation of new drugs requires a deep understanding of the known and currently unknown biological mechanisms underpinning atherosclerosis, accompanied by optimization of traditional drug discovery approaches. Current animal models do not precisely recapitulate the pathobiology underpinning human CVD. Accordingly, a fundamental limitation in early-stage drug discovery has been the lack of consensus regarding an appropriate experimental in vivo model that can mimic human atherosclerosis. However, when coupled with a clear understanding of the specific advantages and limitations of the model employed, preclinical animal models remain a crucial component for evaluating pharmacological interventions. Within this perspective, we will provide an overview of the mechanisms and modalities of atherosclerotic drugs, including those in the preclinical and early clinical development stage. Additionally, we highlight recent preclinical models that have improved our understanding of atherosclerosis and associated clinical consequences and propose model adaptations to facilitate the development of new and effective treatments." @default.
- W4311125931 created "2022-12-23" @default.
- W4311125931 creator A5008962723 @default.
- W4311125931 creator A5010661645 @default.
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- W4311125931 creator A5077280255 @default.
- W4311125931 date "2022-12-01" @default.
- W4311125931 modified "2023-09-27" @default.
- W4311125931 title "Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery" @default.
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