FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311127029> ?p ?o ?g. }

• W4311127029 endingPage "868" @default.
• W4311127029 startingPage "862" @default.
• W4311127029 abstract "The frequency of exacerbations of chronic obstructive pulmonary disease (COPD) is one of the main factors determining the outcome. The search for biomarkers which reflect the risk of exacerbations is one of the urgent scientific and practical objectives. Aim . The study aimed to analyze the relationship between the serum concentration of hyaluronic acid (HA) and the frequency of exacerbations of occupational COPD caused by exposure to silica dust and to substantiate the use of HA as a predictor of exacerbations of COPD. Methods . 78 individuals with a diagnosis of occupational COPD were examined. Respiratory function was assessed based on forced vital capacity of the lungs (FVC, %), the forced expiratory volume in 1 second (FEV 1 , %) and the calculated ratio of these parameters (FEV 1 /FVC, %), i.e., modified Tiffno index. The serum concentration of hyaluronic acid (ng/ml) was determined in all individuals using solid-phase enzyme-linked immunosorbent assay (ELISA). The absolute blood level of eosinophils (cell/μl) was determined by a unified method of morphological study of hemocytes with white blood cell differential count. Results . Serum HA concentration in patients with occupational COPD with frequent exacerbations was 25% higher than in the patients with rare exacerbations (the difference was statistically significant; р = 0,004). The analysis of the obtained data showed that the most significant moderate correlation was found between the level of HA and the frequency of COPD exacerbations (direct relationship, r = 0.32; p < 0.05), and FEV 1 and the frequency of COPD exacerbations (feedback, r = -0.32;p < 0.05). A weak relationship was found between the relative number of eosinophils and the frequency of COPD exacerbations (direct relationship, r = 0.2; p < 0.05). Weak correlations were also found between the level of HA and FEV1 (feedback, r = -0.23; p < 0.05), between the level of HA and the relative number of eosinophils (direct relationship, r = 0.18; p < 0.05). Conclusion . Quantitative analysis of serum HA in patients with occupational COPD can be used in clinical practice as a biochemical marker for assessing the risk of exacerbations and progression of bronchopulmonary pathology." @default.
• W4311127029 created "2022-12-23" @default.
• W4311127029 creator A5023484775 @default.
• W4311127029 creator A5025259520 @default.
• W4311127029 creator A5065416273 @default.
• W4311127029 creator A5068815046 @default.
• W4311127029 creator A5077565388 @default.
• W4311127029 creator A5089405465 @default.
• W4311127029 date "2022-12-12" @default.
• W4311127029 modified "2023-10-16" @default.
• W4311127029 title "Hyaluronic acid as a predictor of exacerbation of occupational chronic obstructive pulmonary disease" @default.
• W4311127029 cites W1774734839 @default.
• W4311127029 cites W2055517350 @default.
• W4311127029 cites W2117918359 @default.
• W4311127029 cites W2148749048 @default.
• W4311127029 cites W2157245567 @default.
• W4311127029 cites W2161713331 @default.
• W4311127029 cites W2267892322 @default.
• W4311127029 cites W2468021853 @default.
• W4311127029 cites W2802221596 @default.
• W4311127029 cites W2940880466 @default.
• W4311127029 cites W3003257379 @default.
• W4311127029 cites W3008273067 @default.
• W4311127029 cites W3048932082 @default.
• W4311127029 cites W3087754885 @default.
• W4311127029 doi "https://doi.org/10.18093/0869-0189-2022-32-6-862-868" @default.
• W4311127029 hasPublicationYear "2022" @default.
• W4311127029 type Work @default.
• W4311127029 citedByCount "0" @default.
• W4311127029 crossrefType "journal-article" @default.
• W4311127029 hasAuthorship W4311127029A5023484775 @default.
• W4311127029 hasAuthorship W4311127029A5025259520 @default.
• W4311127029 hasAuthorship W4311127029A5065416273 @default.
• W4311127029 hasAuthorship W4311127029A5068815046 @default.
• W4311127029 hasAuthorship W4311127029A5077565388 @default.
• W4311127029 hasAuthorship W4311127029A5089405465 @default.
• W4311127029 hasConcept C105702510 @default.
• W4311127029 hasConcept C126322002 @default.
• W4311127029 hasConcept C165637977 @default.
• W4311127029 hasConcept C2776780178 @default.
• W4311127029 hasConcept C2777014857 @default.
• W4311127029 hasConcept C2777529286 @default.
• W4311127029 hasConcept C2777714996 @default.
• W4311127029 hasConcept C2992779976 @default.
• W4311127029 hasConcept C3018587741 @default.
• W4311127029 hasConcept C55520419 @default.
• W4311127029 hasConcept C71924100 @default.
• W4311127029 hasConcept C75603125 @default.
• W4311127029 hasConcept C90924648 @default.
• W4311127029 hasConceptScore W4311127029C105702510 @default.
• W4311127029 hasConceptScore W4311127029C126322002 @default.
• W4311127029 hasConceptScore W4311127029C165637977 @default.
• W4311127029 hasConceptScore W4311127029C2776780178 @default.
• W4311127029 hasConceptScore W4311127029C2777014857 @default.
• W4311127029 hasConceptScore W4311127029C2777529286 @default.
• W4311127029 hasConceptScore W4311127029C2777714996 @default.
• W4311127029 hasConceptScore W4311127029C2992779976 @default.
• W4311127029 hasConceptScore W4311127029C3018587741 @default.
• W4311127029 hasConceptScore W4311127029C55520419 @default.
• W4311127029 hasConceptScore W4311127029C71924100 @default.
• W4311127029 hasConceptScore W4311127029C75603125 @default.
• W4311127029 hasConceptScore W4311127029C90924648 @default.
• W4311127029 hasIssue "6" @default.
• W4311127029 hasLocation W43111270291 @default.
• W4311127029 hasOpenAccess W4311127029 @default.
• W4311127029 hasPrimaryLocation W43111270291 @default.
• W4311127029 hasRelatedWork W2172098606 @default.
• W4311127029 hasRelatedWork W2354650335 @default.
• W4311127029 hasRelatedWork W2375752930 @default.
• W4311127029 hasRelatedWork W2389022931 @default.
• W4311127029 hasRelatedWork W2413531698 @default.
• W4311127029 hasRelatedWork W3031943340 @default.
• W4311127029 hasRelatedWork W3106854829 @default.
• W4311127029 hasRelatedWork W3205757018 @default.
• W4311127029 hasRelatedWork W4365483000 @default.
• W4311127029 hasRelatedWork W2084272319 @default.
• W4311127029 hasVolume "32" @default.
• W4311127029 isParatext "false" @default.
• W4311127029 isRetracted "false" @default.
• W4311127029 workType "article" @default.