Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311128258> ?p ?o ?g. }
- W4311128258 abstract "Stigmasterol is a phytosterol derived from multiple herbaceous plants such as herbs, soybean and tobacco, and it has received much attention for its various pharmacological effects including anti-inflammation, anti-diabetes, anti-oxidization, and lowering blood cholesterol. Multiple studies have revealed that stigmasterol holds promise as a potentially beneficial therapeutic agent for malignant tumors because of its significant anti-tumor bioactivity. It is reported that stigmasterol has anti-tumor effect in a variety of malignancies (e.g., breast, lung, liver and ovarian cancers) by promoting apoptosis, inhibiting proliferation, metastasis and invasion, and inducing autophagy in tumor cells. Mechanistic study shows that stigmasterol triggers apoptosis in tumor cells by regulating the PI3K/Akt signaling pathway and the generation of mitochondrial reactive oxygen species, while its anti-proliferative activity is mainly dependent on its modulatory effect on cyclin proteins and cyclin-dependent kinase (CDK). There have been multiple mechanisms underlying the anti-tumor effect of stigmasterol, which make stigmasterol promising as a new anti-tumor agent and provide insights into research on its anti-tumor role. Presently, stigmasterol has been poorly understood, and there is a paucity of systemic review on the mechanism underlying its anti-tumor effect. The current study attempts to conduct a literature review on stigmasterol for its anti-tumor effect to provide reference for researchers and clinical workers." @default.
- W4311128258 created "2022-12-23" @default.
- W4311128258 creator A5011419121 @default.
- W4311128258 creator A5026604505 @default.
- W4311128258 creator A5052160997 @default.
- W4311128258 creator A5059574635 @default.
- W4311128258 creator A5060999523 @default.
- W4311128258 creator A5063880073 @default.
- W4311128258 creator A5084808312 @default.
- W4311128258 date "2022-12-12" @default.
- W4311128258 modified "2023-10-15" @default.
- W4311128258 title "Advances in Stigmasterol on its anti-tumor effect and mechanism of action" @default.
- W4311128258 cites W1512072225 @default.
- W4311128258 cites W1529230314 @default.
- W4311128258 cites W1620160353 @default.
- W4311128258 cites W1799757598 @default.
- W4311128258 cites W1871146198 @default.
- W4311128258 cites W1952507411 @default.
- W4311128258 cites W1980076480 @default.
- W4311128258 cites W1986843662 @default.
- W4311128258 cites W1988201936 @default.
- W4311128258 cites W1992178732 @default.
- W4311128258 cites W1994711032 @default.
- W4311128258 cites W2003020118 @default.
- W4311128258 cites W2013218770 @default.
- W4311128258 cites W2016926816 @default.
- W4311128258 cites W2019083914 @default.
- W4311128258 cites W2024492396 @default.
- W4311128258 cites W2028635429 @default.
- W4311128258 cites W2031281657 @default.
- W4311128258 cites W2034577974 @default.
- W4311128258 cites W2035340148 @default.
- W4311128258 cites W2037256881 @default.
- W4311128258 cites W2042619042 @default.
- W4311128258 cites W2043216151 @default.
- W4311128258 cites W2070570765 @default.
- W4311128258 cites W2082580993 @default.
- W4311128258 cites W2085447947 @default.
- W4311128258 cites W2086026291 @default.
- W4311128258 cites W2089643849 @default.
- W4311128258 cites W2095583692 @default.
- W4311128258 cites W2098167813 @default.
- W4311128258 cites W2102601355 @default.
- W4311128258 cites W2104718696 @default.
- W4311128258 cites W2126649352 @default.
- W4311128258 cites W2127410754 @default.
- W4311128258 cites W2142393908 @default.
- W4311128258 cites W2150026213 @default.
- W4311128258 cites W2156920627 @default.
- W4311128258 cites W2158025958 @default.
- W4311128258 cites W2182443159 @default.
- W4311128258 cites W2259709654 @default.
- W4311128258 cites W2279453021 @default.
- W4311128258 cites W2341442578 @default.
- W4311128258 cites W2395275274 @default.
- W4311128258 cites W2415480695 @default.
- W4311128258 cites W2438866487 @default.
- W4311128258 cites W2491510063 @default.
- W4311128258 cites W2508069933 @default.
- W4311128258 cites W2508893577 @default.
- W4311128258 cites W2516978391 @default.
- W4311128258 cites W2517888724 @default.
- W4311128258 cites W2527945531 @default.
- W4311128258 cites W2562413738 @default.
- W4311128258 cites W2570959155 @default.
- W4311128258 cites W2571751736 @default.
- W4311128258 cites W2587403841 @default.
- W4311128258 cites W2611018137 @default.
- W4311128258 cites W2616464132 @default.
- W4311128258 cites W2620696047 @default.
- W4311128258 cites W2649656222 @default.
- W4311128258 cites W2731227355 @default.
- W4311128258 cites W2735119841 @default.
- W4311128258 cites W2740953687 @default.
- W4311128258 cites W2747651708 @default.
- W4311128258 cites W2748042438 @default.
- W4311128258 cites W2749532801 @default.
- W4311128258 cites W2749711897 @default.
- W4311128258 cites W2765434133 @default.
- W4311128258 cites W2767523520 @default.
- W4311128258 cites W2775137578 @default.
- W4311128258 cites W2783032256 @default.
- W4311128258 cites W2794007299 @default.
- W4311128258 cites W2801988573 @default.
- W4311128258 cites W2809289941 @default.
- W4311128258 cites W2884682472 @default.
- W4311128258 cites W2886594044 @default.
- W4311128258 cites W2892759513 @default.
- W4311128258 cites W2894012588 @default.
- W4311128258 cites W2902570465 @default.
- W4311128258 cites W2903851061 @default.
- W4311128258 cites W2905039795 @default.
- W4311128258 cites W2913448436 @default.
- W4311128258 cites W2916621234 @default.
- W4311128258 cites W2949776135 @default.
- W4311128258 cites W2965864221 @default.
- W4311128258 cites W2965873243 @default.
- W4311128258 cites W2970254070 @default.
- W4311128258 cites W2980403895 @default.
- W4311128258 cites W2982979216 @default.