FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311133809> ?p ?o ?g. }

• W4311133809 endingPage "1533" @default.
• W4311133809 startingPage "1533" @default.
• W4311133809 abstract "Children born to mothers, with or at risk, of human immunodeficiency virus type-1 (HIV-1) infection are on the rise due to affordable access of antiretroviral therapy (ART) to pregnant women or those of childbearing age. Each year, up to 1.3 million HIV-1-infected women on ART have given birth with recorded mother-to-child HIV-1 transmission rates of less than 1%. Despite this benefit, the outcomes of children exposed to antiretroviral drugs during pregnancy, especially pre- and post- natal neurodevelopment remain incompletely understood. This is due, in part, to the fact that pregnant women are underrepresented in clinical trials. This is underscored by any potential risks of neural tube defects (NTDs) linked, in measure, to periconceptional usage of dolutegravir (DTG). A potential association between DTG and NTDs was first described in Botswana in 2018. Incidence studies of neurodevelopmental outcomes associated with DTG, and other integrase strand transfer inhibitors (INSTIs) are limited as widespread use of INSTIs has begun only recently in pregnant women. Therefore, any associations between INSTI use during pregnancy, and neurodevelopmental abnormalities remain to be explored. Herein, United States Food and Drug Administration approved ARVs and their use during pregnancy are discussed. We provide updates on INSTI pharmacokinetics and adverse events during pregnancy together with underlying mechanisms which could affect fetal neurodevelopment. Overall, this review seeks to educate both clinical and basic scientists on potential consequences of INSTIs on fetal outcomes as a foundation for future scientific investigations." @default.
• W4311133809 created "2022-12-23" @default.
• W4311133809 creator A5018546819 @default.
• W4311133809 creator A5037860165 @default.
• W4311133809 creator A5058974129 @default.
• W4311133809 date "2022-12-09" @default.
• W4311133809 modified "2023-10-18" @default.
• W4311133809 title "HIV-1 Integrase Strand Transfer Inhibitors and Neurodevelopment" @default.
• W4311133809 cites W1483536094 @default.
• W4311133809 cites W1504544942 @default.
• W4311133809 cites W1647405314 @default.
• W4311133809 cites W1911306676 @default.
• W4311133809 cites W1943114611 @default.
• W4311133809 cites W1946365220 @default.
• W4311133809 cites W1961885071 @default.
• W4311133809 cites W1966716189 @default.
• W4311133809 cites W1970904547 @default.
• W4311133809 cites W1971818156 @default.
• W4311133809 cites W1976081557 @default.
• W4311133809 cites W1982672839 @default.
• W4311133809 cites W1987306939 @default.
• W4311133809 cites W1991614900 @default.
• W4311133809 cites W1996885616 @default.
• W4311133809 cites W2008398629 @default.
• W4311133809 cites W2021606784 @default.
• W4311133809 cites W2025481927 @default.
• W4311133809 cites W2027303551 @default.
• W4311133809 cites W2027917639 @default.
• W4311133809 cites W2029589529 @default.
• W4311133809 cites W2036455711 @default.
• W4311133809 cites W2039206870 @default.
• W4311133809 cites W2044001092 @default.
• W4311133809 cites W2049031559 @default.
• W4311133809 cites W2049879969 @default.
• W4311133809 cites W2055534742 @default.
• W4311133809 cites W2055535173 @default.
• W4311133809 cites W2071359561 @default.
• W4311133809 cites W2080161423 @default.
• W4311133809 cites W2088657555 @default.
• W4311133809 cites W2092092581 @default.
• W4311133809 cites W2094241860 @default.
• W4311133809 cites W2094811879 @default.
• W4311133809 cites W2098605123 @default.
• W4311133809 cites W2099799148 @default.
• W4311133809 cites W2102146294 @default.
• W4311133809 cites W2112646001 @default.
• W4311133809 cites W2116229285 @default.
• W4311133809 cites W2121317746 @default.
• W4311133809 cites W2124501351 @default.
• W4311133809 cites W2133117185 @default.
• W4311133809 cites W2139430929 @default.
• W4311133809 cites W2140422126 @default.
• W4311133809 cites W2143827232 @default.
• W4311133809 cites W2151003930 @default.
• W4311133809 cites W2151433848 @default.
• W4311133809 cites W2151589354 @default.
• W4311133809 cites W2151945046 @default.
• W4311133809 cites W2152518380 @default.
• W4311133809 cites W2158241217 @default.
• W4311133809 cites W2162317646 @default.
• W4311133809 cites W2165447838 @default.
• W4311133809 cites W2167984484 @default.
• W4311133809 cites W2171988069 @default.
• W4311133809 cites W2262960751 @default.
• W4311133809 cites W2290540040 @default.
• W4311133809 cites W2314735747 @default.
• W4311133809 cites W2322037963 @default.
• W4311133809 cites W2328785492 @default.
• W4311133809 cites W2332064983 @default.
• W4311133809 cites W2335025772 @default.
• W4311133809 cites W2337391513 @default.
• W4311133809 cites W2394662221 @default.
• W4311133809 cites W2395339327 @default.
• W4311133809 cites W2415624622 @default.
• W4311133809 cites W2416289930 @default.
• W4311133809 cites W2422955030 @default.
• W4311133809 cites W2463268415 @default.
• W4311133809 cites W2511788713 @default.
• W4311133809 cites W2530252998 @default.
• W4311133809 cites W2554692247 @default.
• W4311133809 cites W2556153964 @default.
• W4311133809 cites W2560519768 @default.
• W4311133809 cites W2562322368 @default.
• W4311133809 cites W2573307309 @default.
• W4311133809 cites W2600344958 @default.
• W4311133809 cites W2608989554 @default.
• W4311133809 cites W2615380358 @default.
• W4311133809 cites W263749769 @default.
• W4311133809 cites W2690342936 @default.
• W4311133809 cites W2728117782 @default.
• W4311133809 cites W2735466521 @default.
• W4311133809 cites W2738403781 @default.
• W4311133809 cites W2752494178 @default.
• W4311133809 cites W2753489952 @default.
• W4311133809 cites W2753599284 @default.
• W4311133809 cites W2755126513 @default.
• W4311133809 cites W2766138644 @default.
• W4311133809 cites W2767583969 @default.

• next