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- W4311134098 abstract "Bile salts stabilized nanovesicles (bilosomes) have received tremendous attention in the previous decade due to their vast preferabilities as well as the flexibility of their modification for various purposes. Bile salts are naturally occurring endogenous surfactants owning very distinguished biological compatibility, biodegradability, and minimal toxicity. Bile salts can as well boost transport across biological membranes either by raising drug dissolution or altering cellular membrane permeability. In the bilosomal structure, the bile salts are embedded between lipid layers forming a distinctive closed shape. Bilosomes have many privileges over other vesicular drug delivery systems including synchronized unique gastrointestinal stability and high transdermal permeability. The review attempted to present an overview exploring influences of structural composition and methods for preparation on the characterization of bilosomes. The applications of bilosomes in different physiological routes were also discussed. Future perspective for the nascent promising nanovesicular system may include a deeper investigation into the fate of bilosomes and the application of the advanced technology for targeting purposes as this delivery system hasn't been exploited as it should be yet. Considerations should be given to conducting additional in-vivo and preclinical studies to prepare the delivery system for competition in the pharmaceutical market." @default.
- W4311134098 created "2022-12-23" @default.
- W4311134098 creator A5013475789 @default.
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- W4311134098 date "2023-01-01" @default.
- W4311134098 modified "2023-10-14" @default.
- W4311134098 title "Bile salt stabilized nanovesicles as a promising drug delivery technology: A general overview and future perspectives" @default.
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- W4311134098 doi "https://doi.org/10.1016/j.jddst.2022.104057" @default.
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